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On the Voltage Dependence of Neurotransmitter Release

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Calcium, Neuronal Function and Transmitter Release

Part of the book series: Topics in the Neurosciences ((TNSC,volume 1))

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Abstract

The process of nerve evoked transmitter release requires Ca++ in the extracellular medium (1,2). The specific link for release is the increase in inracellular Ca++ concentration (3,4) resulting from terminal depolarization and inflow of calcium. Indeed, this is considered the only role of membrane depolarization; no additional effects are presumed in any of the processes that follow the entry of calcium ions and lead to the fusion of synaptic vesicles with the terminal membrane, exocytosis and release. If it is accepted that Ca++ ions are the only trigger for release, it follows that initiation of release results from an increase in intracellular Ca++ concentrations near critical sites. Correspondingly, termination of release must result from a drop in Ca++ concentration near these critical sites to levels insufficient to support release (5,6,7).

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References

  1. Castillo D, Katz, B: The effect of magnesium on the activity of motor nerve endings. J. Riysiol. 124, 553–559, 1954.

    Google Scholar 

  2. Katz, B, Miledi, R: The effect of calcium on acetylcholine release from motor nerve terminals. Proc. Roy. Soc. (London). B. 161, 496–503, 1965.

    Article  CAS  Google Scholar 

  3. Miledi, R: Transmitter released induced by injection of calcium ions into nerve teiminals. Proc. R. Soc. B. 183, 421–425, 1973.

    Article  CAS  Google Scholar 

  4. Llinas, R, Nicholson, C: Calcium role in depolarization-secretion coupling: An aequorin study in squid giant synapse. Proc. Nat. Acad. Sci. USA. Vol. 72, No. 1 187–190, 1975.

    Article  PubMed  CAS  Google Scholar 

  5. Katz, B, and Miledi, R: The role of calcium in neuromuscular facilitation. J. Riysiol. 195: 481–492, 1968.

    CAS  Google Scholar 

  6. Zucker, R.S., and Steckbridge, N: Presynaptic calcium diffusion and the time courses of transmitter release and synaptic facilitation at the squid giant synapse. J. Neuroscience, 3: 1263–1269, 1983.

    CAS  Google Scholar 

  7. Steckbridge, N, Moore, J.W: Dynamics of intracellular calcium and its possible relationship to phasic transmitter release and facilitation at the grog neuromuscular junction. J. of Neuroscience 4: 803–811, 1984.

    Google Scholar 

  8. Rahamimoff, R: A dual effect of calcium ions on neuromuscular facilitation. J. Riysiol. 195: 471–480, 1968.

    CAS  Google Scholar 

  9. Smith, S.J., Charlton, M.P., Zucker, R.S: Arsenazo III reveals long-lasting intracellular calcium transient following the action potential in squid giant presynaptic terminal. Biological Bulletin. Vol. 159, 491–2, 1980.

    Google Scholar 

  10. Pamas, H., Dudel, J., Parnas, I: Neurotransmitter release and its facilitation in crayfish. I. Saturation kinetics of release and of entry and removal of calcium. Pflugers Arch. 393: 1–14, 1982.

    Google Scholar 

  11. Pamas, I., Pamas, H., Eudel, J: Neurotransmitter release and its facilitation in crayfish. II. Duration of facilitation and removal processes of calcium from the terminal. Pflugers Arch. 393: 232–236, 1982.

    Google Scholar 

  12. Pamas, H., Dudel, J., Pamas, I: Neurotransmitter release and its facilitation in crayfish IV. The effect of Mg ions on the duration of facilitation. Pflugers Arch. 395: 1–5, 1982.

    Google Scholar 

  13. Pamas, I., Pamas, H., Eudel, J: Neurotransmitter release and its facilitation in crayfish muscle v. Baris for synapse differentiation of the fast and slow type in one axon. Pflugers Arch. 395: 261–270, 1982.

    Article  Google Scholar 

  14. Dudel, J., Pamas, I., Pamas, H: Neurotransmitter release and its facilitation in crayfish III. Amplitude of facilitation and inhibition of entry of calcium into the terminal by magnesium. Pflugers Arch. 393: 237–242, 1982.

    Article  PubMed  CAS  Google Scholar 

  15. Pamas, H., Segel, L.A.: A theoretical explanation for some effects of calcium on the facilitation of neurotransmitter release.

    Google Scholar 

  16. Zucker, R.S: Characteristics of crayfish neuromuscular facilitation and their calcium dependence. J. Physiol. 241: 91–110, 1974.

    PubMed  CAS  Google Scholar 

  17. Staggs, D.R. Pofcher, E, L’Heureux, Ramona, Ortiz, CL. Orkand, R.K: Excitatory neuromuscular transmission in crayfish. Calcium dependence is unaffected by Picrotoxin. J. Neurobiol. Vol. II, No. 6, 629–632, 1980.

    Google Scholar 

  18. Mallart, A, Martin, A.R: Two components of facilitation at the neuromuscular junction of the frog. J. Riysiol. 191: 191–201, 1967.

    Google Scholar 

  19. Balnare, R.J., Gage, P.W: Cn facilitation of transmitter release at the toad neuromuscular junction. J. Physiol. 239: 657–675, 1974.

    Google Scholar 

  20. Balnare, R.J., Gage, P.W: Facilitation of transmitter secretion from toad motor nerve terminals during brief trains of action potentials. J. Physiol. 266: 435–451, 1977.

    Google Scholar 

  21. Smith, S.J. Zucker, R.S: Aequorin response facilitation and intracellular calcium accumulation in molluscan neurones. J. Pnysiol. 300: 167–196, 1980.

    CAS  Google Scholar 

  22. Miledi, R.F.R.S. Parker I: Calcium transients recorded with arsenazo III in the presynaptic terminal of the squid giant synapse. Proc. R. Soc. Lond. B 212: 197–211, 1981.

    Article  PubMed  CAS  Google Scholar 

  23. Eodge, F.A. Jr. Rahaminoff, R: Cooperative action of calcium ions in transmitter release at the neuromuscular junction. J. Riysiol. 193: 419–432, 1967.

    Google Scholar 

  24. Barrett, E.F., Stevens, C.F: The kinetics of transmitter release at the frog neuromuscular junction. J. Physiol, 227: 691–708, 1972.

    PubMed  CAS  Google Scholar 

  25. Zucker, R.S.: Biophys. J. Feb. (abstract), 1984.

    Google Scholar 

  26. Pamas, H. Segal, L.A.: Exhaustion of calcium does not terminate evoked neurotransmitter release. J. Theor. Biol. 107: 345–365, 1984.

    Article  Google Scholar 

  27. Katz, B., Miledi, R: The measurements of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction. Proc. R. Soc. B 161, 483–495, 1965.

    Article  CAS  Google Scholar 

  28. Datyner, N.B., Gage, P.W.: Phasic secretion of acetylcholine at a mammalian neuromuscular junction. J. Physiol. 303: 299–314, 1980.

    PubMed  CAS  Google Scholar 

  29. Pamas, H., Segel, L.A.: A theoretical study of calcium entry in nerve terminals with application to neurotransmitter release. J. Theor. Biol. 91: 125–169, 1981.

    Article  Google Scholar 

  30. Llinas, R. Steinberg, I.Z., Walteon, K: Relationship between presynaptic calcium current and partsynaptic potential insquid giant synapse. Biophys. v. 323–352, 1981.

    Google Scholar 

  31. Dudel, J,, Pamas, I., Pamas, H: Neurotransmitter release and its facilitation in crayfish muscle. VI release determined by both intracellular calcium concentration and depolarization of the nerve terminal. Pflugers Arch., 1983.

    Google Scholar 

  32. Llinas, R., Sugimori, M., Bower, J.M: Visualization of depolarization-evoked presynaptic calcium entry and voltage dependence of transmitter release in giant synapse. Biological Bull. 165: 529, 1983.

    Google Scholar 

  33. Pamas, H., Dudel, J., Pamas, I: Neurotransmitter release and its facilitation in crayfish VII. Ca in flow does not determine the time course of phasic release. Pflugers Arch, (submitted).

    Google Scholar 

  34. Pamas, I., Pamas, H., and Dudel, J: Neurotransmitter release and its facilitation in crayfish. VIII. Direct activation of phasic release by depolarization. Pflugers Arch. (submitted).

    Google Scholar 

  35. Dudel, J., Pama, I., Pamas, H. Neurotransmitter release and its facilitation in crayfish IX. Modulations of release by hyperpolarizing pulses. Pflugers Arch. (submitted).

    Google Scholar 

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Authors and Affiliations

  1. Dept. Neurobiology, Institute of Life Sciences, Hebrew University of Jerusalem, Munich, Germany

    H. Parnas & I. Parnas

  2. Institute of Physiology, Technical University, Munich, Germany

    J. Dudel

Authors
  1. H. Parnas
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  2. I. Parnas
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  3. J. Dudel
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Editor information

Editors and Affiliations

  1. The Hebrew University, Jerusalem, Israel

    Rami Rahamimoff

  2. University College London, London, England

    Bernard Katz

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© 1986 Martinus Nijhoff Publishing, Boston

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Parnas, H., Parnas, I., Dudel, J. (1986). On the Voltage Dependence of Neurotransmitter Release. In: Rahamimoff, R., Katz, B. (eds) Calcium, Neuronal Function and Transmitter Release. Topics in the Neurosciences, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2307-5_14

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  • DOI: https://doi.org/10.1007/978-1-4613-2307-5_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9420-7

  • Online ISBN: 978-1-4613-2307-5

  • eBook Packages: Springer Book Archive

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