Abstract

Genetic causes are primarily responsible only for 8% of congenital heart disease, [1,2] and 2% are of environmental origin. The remaining 90% of cases are due to interaction of genetic and environmental factors in the framework of multifactorial etiology. [2–6] Teratogens, agents capable of inducing congenital anomalies, participate in at least two of these etiological groups: those which are primarily environmental and those of multifactorial origin.

Keywords

Cardiomyopathy Amphetamine Valproate Thalassemia Phenothiazine 

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References

  1. 1.
    Morgan BC: Incidence, etiology, and classification of congenital heart disease. Pediatr Clin North Am 25:721–724, 1978.PubMedGoogle Scholar
  2. 2.
    Nora JJ, Nora AH: Genetics and counseling in cardiovascular diseases. Springfield, Charles C. Thomas, 1978.Google Scholar
  3. 3.
    Fraser FC: The multifactorial/threshold concept — Uses and misuses. Teratology 14:267–280, 1976.PubMedGoogle Scholar
  4. 4.
    Nora JJ: Multifactorial inheritance hypothesis for the etiology of congenital heart disease. Circulation 38:604–617, 1968.PubMedGoogle Scholar
  5. 5.
    Nora JJ, Nora AH: Genetic and environmental factors in etiology of congenital heart diseases. South Med J 69:919–926, 1976.PubMedGoogle Scholar
  6. 6.
    Pexieder T: Genetic aspects of congenital heart disease. In: Mechanisms of cardiac morphogenesis and teratogenesis, Pexieder T (ed), New York, Raven Press, 1981, p 383–387.Google Scholar
  7. 7.
    Schinzel AA: Cardiovascular defects associated with chromosomal aberrations and malformation syndromes. In: Progress in medical genetics — Genetics of cardiovascular disease, Fifth Volume, Steinberg AG, Bearn AG, Motulsky AG, Childs B (eds), Philadelphia, W.B. Saunders Co., 1983, p 303–379.Google Scholar
  8. 8.
    Nora JJ, Nora AH: Genetic epidemiology of congenital heart diseases. In: Progress in medical genetics — Genetics of cardiovascular disease, Fifth Volume, Steinberg AG, Bearn AG, Motulsky AG, Childs B (eds), Philadelphia, W.B. Saunders Co., 1983, p 91–137.Google Scholar
  9. 9.
    Perlin MJ, Simon KJ: The epidemiology of drug use during pregnancy. Int J Addict 14:355–364, 1979.PubMedGoogle Scholar
  10. 10.
    Brocklebank JC, Ray WA, Federspiel CF, Schaffner W: Drug prescribing during pregnancy — Controlled study of Tennessee Medicaid recipients. Am J Obstet Gynecol 132:235–244, 1978.PubMedGoogle Scholar
  11. 11.
    Buchanan N, Bomvana T: Maternal drug ingestion among urban blacks. S Afr Med J 55:616, 1979.PubMedGoogle Scholar
  12. 12.
    Degenhardt KH, Kerken H, Knoerr K, Koller S, Wiedemann HR: Drug usage and fetal development: Preliminary evaluations of a prospective investigation. In: Drugs and fetal development, Klingberg MA, Abramovici A, Chemke J (eds), New York and London, Plenum Press, 1972, p 467–479.Google Scholar
  13. 13.
    Jacobs D: Maternal drug ingestion and congenital malformations. S Afr Med J 49:2073–2080, 1975.PubMedGoogle Scholar
  14. 14.
    Rao JM, Arulappu R: Drug use in pregnancy: How to avoid problems. Drugs 22:409–414, 1981.PubMedGoogle Scholar
  15. 15.
    Doering PL, Stewart RB: The extent and character of drug consumption during pregnancy. JAMA 239:843–847, 1978.PubMedGoogle Scholar
  16. 16.
    Hill RM: Drugs ingested by pregnant women. Clin Pharmacol Ther 14:654–659, 1973.PubMedGoogle Scholar
  17. 17.
    Hill RM, Craig JP, Chaney MD, Tennyson LM, McCulley LB: Utilization of over-the-counter drugs during pregnancy. Clin Obstet Gynecol 20:381–394, 1977.PubMedGoogle Scholar
  18. 18.
    Naga Rani MA, Thanga MJ, Kumari SK: Pattern and extent of drug intake during pregnancy in Indian women. Indian J Med Res 74:297–300, 1981.PubMedGoogle Scholar
  19. 19.
    Nelson MM, Forfar JO: Associations between drugs administered during pregnancy and congenital abnormalities of the fetus. Br Med J I:523–527, 1971.Google Scholar
  20. 20.
    Nora JJ, Nora AH, Sommerville RJ, Hill RM, McNamara DG: Maternal exposure to potential teratogens. JAMA 202:1065–1069, 1967.PubMedGoogle Scholar
  21. 21.
    Sannerstedt R, Berglund F, Flode H, Hedstrand AG: Medication during pregnancy and breastfeeding — A new Swedish system for classifying drugs. Int J Clin Pharmacol Ther Toxicol 18:45–49, 1980.PubMedGoogle Scholar
  22. 22.
    Rayburn W, Wible-Kant J, Bledsoe P: Changing trends in drug use during pregnancy. J Reprod Med 27:569–575, 1982.PubMedGoogle Scholar
  23. 23.
    Cohlan SO: Drugs and pregnancy. In: Perinatal medicine today, Young BC (ed), New York, Alan R. Liss, Inc., 1980, p 77–96.Google Scholar
  24. 24.
    Maugh TH II: Chemical carcinogenesis: A long neglected field blossoms. Science 183:940–944, 1974.PubMedGoogle Scholar
  25. 25.
    Stern L: In vivo assessment of the teratogenic potential of drugs in humans. Obstet Gynecol 58(Suppl):3s–8s, 1981.PubMedGoogle Scholar
  26. 26.
    Millstein LG: FDA’s “pregnancy categories.” N Engl J Med 303:706, 1980.PubMedGoogle Scholar
  27. 27.
    Stanley FJ: Fetotoxic chemicals and drugs. Med J Aust 1:688–693, 1981.PubMedGoogle Scholar
  28. 28.
    Shepard TH: Detection of human teratogenic agents. J Pediatr 101:810–815, 1982.PubMedGoogle Scholar
  29. 29.
    Clay SA, McVie R, Chen H: Possible teratogenic effect of valproic acid. J Pediatr 99:828, 1981.PubMedGoogle Scholar
  30. 30.
    Dalens B, Raynaud EJ, Gaulme J: Teratogenicity of valproic acid. J Pediatr 97:332, 1980.PubMedGoogle Scholar
  31. 31.
    Gomez MR: Possible teratogenicity of valproic acid. J Pediatr 98:508, 1981.PubMedGoogle Scholar
  32. 32.
    Stanley OH, Chambers TL, Jeavons PM, Macrae KD: Sodium valproate and neural tube defects. Lancet 2:1282, 1982.Google Scholar
  33. 33.
    Inman WHW, Rawson NSB: Prescription-event monitoring for drug safety. In: The impact of computer technology on drug information, Manell P, Johansson SG (eds), Amsterdam, North-Holland Publishing Co., 1982, p 153–160.Google Scholar
  34. 34.
    Bodendorfer TW, Briggs GG, Gunning JE: Obtaining drug exposure histories during pregnancy. Am J Obstet Gynecol 135:490–494, 1979.PubMedGoogle Scholar
  35. 35.
    Beeley L: Adverse effects of drugs in the first trimester of pregnancy. Clin Obstet Gynecol 8:261–274, 1981.Google Scholar
  36. 36.
    Soller RW, Stander H: Maternal drug exposure and perinatal intracranial hemorrhage. Obstet Gynecol 58:735–736, 1981.PubMedGoogle Scholar
  37. 37.
    Laake E, Ryan ET: Statistics of drug consumption in Norway. In: The impact of computer technology on drug information, Manell P, Johansson SG (eds), Amsterdam, North-Holland Publishing Co., 1982, p 133–137.Google Scholar
  38. 38.
    Boethius G: Recording of drug prescriptions in the County of Jamtland, Sweden. Eur J Clin Pharmacol 12:45–49, 1977.PubMedGoogle Scholar
  39. 39.
    Rawson NSB: Prescription event monitoring. In: The impact of computer technology on drug information, Manell P, Johansson SG (eds), Amsterdam, North-Holland Publishing Co., 1982, p 203–207.Google Scholar
  40. 40.
    Jick H, Holmes LB, Hunter JR, Stergachis A: First-trimester drug use and congenital disorders. JAMA 246:343–346, 1981.PubMedGoogle Scholar
  41. 41.
    Schreiner WE, Kunz J: Hazards to pregnancy caused by pharmaceuticals and semi-luxuries. Arch Gynecol 232:315–327, 1981.Google Scholar
  42. 42.
    Heinonen OP, Slone D, Monson RR, Hook EB, Shapiro S: Cardiovascular birth defects and antenatal exposure to female sex hormones. N Engl J Med 296:67–69, 1977.PubMedGoogle Scholar
  43. 43.
    Last JM (ed): A dictionary of epidemiology. New York, Oxford University Press, 1983.Google Scholar
  44. 44.
    Roht LH, Selwyn BJ, Holguin AH, Christensen BL: Principles of epidemiology. A self teaching guide. New York, Academic Press, 1982.Google Scholar
  45. 45.
    Heinonen OP, Slone D, Shapiro S: Birth defects and drugs in pregnancy. Littleton, Publ Sci Group, 1977.Google Scholar
  46. 46.
    Morton RF, Hebel JR: A study guide to epidemiology and biostatistics including 100 multiple-choice questions. Baltimore, University Park Press, 1977.Google Scholar
  47. 47.
    Woods JS: Epidemiologic considerations in the design of toxicologic studies: An approach to risk assessment in humans. Fed Proc 38:1891–1896, 1979.PubMedGoogle Scholar
  48. 48.
    Gompertz D: Assessment of risk by biological monitoring. Br J Ind Med 38:198–201, 1981.PubMedGoogle Scholar
  49. 49.
    Petitti DB: Studying potential reproductive hazards. In: Environmental epidemiology — Risk assessment, Prentice RL, Whittemore AS (eds), Philadelphia, SIAM, 1982, p 49–61.Google Scholar
  50. 50.
    Walker AM: The use of case series data for risk assessment. In: Environmental epidemiology — Risk assessment, Prentice RL, Whittemore AS (eds), Philadelphia, SIAM, 1982, p 193–201.Google Scholar
  51. 51.
    Pexieder T: Anomalies congénitales — prévention par l’usage d’études épidémiologiques, l’emploi des banques de données et thérapeutiques prénatales. Méd Hyg 41:2017–2034, 1983.Google Scholar
  52. 52.
    Pexieder T, Müller JP: New data base on human drug-related teratogenicity risks. Teratology 25:66A, 1982.Google Scholar
  53. 53.
    Nishimura H, Tanimura T: Clinical aspects of the teratogenicity of drugs. Amsterdam, Excerpta Medica, 1976.Google Scholar
  54. 54.
    Schardein JL: Drugs as teratogens. Cleveland, CRC Press Inc., 1976.Google Scholar
  55. 55.
    Rumeau-Rouquette C, Goujard J, Huel G, Kaminski M: Santé publique — malformations congénitales. Risques perinatals. Enquête prospective. Paris, Editions INSERM, 1978.Google Scholar
  56. 56.
    Shepard TH: Catalog of teratogenic agents, Third Edition (Second Printing). Baltimore, The Johns Hopkins University Press, 1981.Google Scholar
  57. 57.
    Weatherall JAC (ed): Eurocat report — Registration of congenital abnormalities and multiple births, No. 5, 1979–1980–1981, Brussels, 1983.Google Scholar
  58. 58.
    Weatherall JAC (ed): Eurocat report — Registration of congenital abnormalities and multiple births, No. 6, January-December 1982, Brussels, 1983.Google Scholar
  59. 59.
    Stocker F, Arbenz U, Desbaillets P, Feuardent R, Friedli B, Geiger K, Haenni B, Kuenzler R, Kuersteiner W, Mottu Ch, Oberhaensli J, Rutishauser M, Schwarzenbach P, Weber JW, Wyler F: Vorkommen und Verlauf angeborerner Herzfehler im ersten Lebensjahr in der Schweiz. Pädiat Fortbild Praxis 51:98–100, 1980.Google Scholar
  60. 60.
    Emanuel R: Genetics and congenital heart disease. Br Heart J 32:281–291, 1970.PubMedGoogle Scholar
  61. 61.
    Esscher E, Michaelsson M, Smedby B: Cardiovascular malformation in infant death. 10-year clinical and epidemiological study. Br Heart J 37:824–829, 1975.PubMedGoogle Scholar
  62. 62.
    Freire-Maia N, Arce-Gomez B: The epidemiology of congenital cardiovascular malformations. Hum Hered 21:209–215, 1971.PubMedGoogle Scholar
  63. 63.
    Kienast W, Wagner G, Klaube A: Hereditary prognosis in congenital cardiopathies. In: Humangenetische Beratung Genetisch Belasteter Personen, Bach H (ed), Jena, F. Schille. University, 1975, p 206–211.Google Scholar
  64. 64.
    Klimentová T: Some genetic aspects of congenital heart defects. Bratisl Lék Listy 67:221–226, 1977.PubMedGoogle Scholar
  65. 65.
    Mitchell SC, Sellmann AH, Westphal MC, Park J: Etiologic correlates in a study of congenital heart disease in 56,109 births. Am J Cardiol 28:653–657, 1971.PubMedGoogle Scholar
  66. 66.
    Pentek E, Szendrei E: Incidence of congenital heart disease in Hungary: Pecs and Baranya County. Acta Paediatr Scand 16:55–57, 1975.Google Scholar
  67. 67.
    Bound JP, Logan WF: Incidence of congenital heart disease in Blackpool 1957–1971. Br Heart J 39:445–451, 1977.PubMedGoogle Scholar
  68. 68.
    Caralls DG, Char F, Graber JD, Voigt GC: Delineation of multiple cardiac anomalies associated with the Noonan syndrome in an adult and review of the literature. Johns Hopkins Med J 134:346–355, 1974.Google Scholar
  69. 69.
    Hoffman JIE, Christianson R: Congenital heart disease in a cohort of 19,502 births with long-term follow-up. Am J Cardiol 42:641–647, 1978.PubMedGoogle Scholar
  70. 70.
    Kenna AP, Smithells RW, Fiedling DW: Congenital heart diseases in Liverpool: 1960–1969. Q J Med 44:17–44, 1975.PubMedGoogle Scholar
  71. 71.
    Lenz W, Knapp K: Foetal malformations due to thalidomide. Ger Med Monthly 7:253–258, 1962.Google Scholar
  72. 72.
    Lenz W, Knapp K: Thalidomide embryopathy. Arch Environ Health 5:100–105, 1962.PubMedGoogle Scholar
  73. 73.
    Keck EW, Roloff D, Markworth P: Kardiovaskuläre Befunde bei Kindern mit Thalidomid-Dysmelie-Syndrom. Verh Dtsch Ges Herz Kreislaufforsch 37:364–370, 1971.Google Scholar
  74. 74.
    Kreipe U: Missbildungen innerer Organe bei Thalidomidembryopathie. Ein Beitrag zur Bestimmung der sensiblen Phase bei Thalidomideinnahme in der Frühschwangerschaft. Arch Kinderheilk 176:33–61, 1967.PubMedGoogle Scholar
  75. 75.
    Yang TS, Shen Cheng CC, Wang CM: A survey of thalidomide embryopathy in Taiwan. J Formos Med Assoc 76:546–562, 1977.Google Scholar
  76. 76.
    Leck IM, Millar ELM: Incidence of malformations since the introduction of thalidomide. Br Med J II:16–20, 1962.Google Scholar
  77. 77.
    Pliess G: Thalidomide and congenital abnormalities. Lancet 1:1128–1129, 1962.Google Scholar
  78. 78.
    Schumacher H, Odunjo F: Truncus arteriosus communis persistens bei sogenannter Thalidomid-Embryopathie. Dtsch Med Wochenschr 36:1743–1748, 1963.Google Scholar
  79. 79.
    Ando J, Kobayashi T, Sato R, Yasuda H: Congenital aortic regurgitation observed in a thalidomide-deformed child. Jpn Heart J 19:823–827, 1978.PubMedGoogle Scholar
  80. 80.
    Milkovich L, Van den Berg BJ: Effects of antenatal exposure to anorectic drugs. Am J Obstet Gynecol 129:637–642, 1977.PubMedGoogle Scholar
  81. 81.
    Eriksson M, Larsson G, Zetterstroem R: Amphetamine addiction and pregnancy. Acta Obstet Gynecol Scand 60:253–260, 1981.PubMedGoogle Scholar
  82. 82.
    American Society of Anesthesiologists: Occupational disease among operating room personnel: A national study. Anesthesiology 41:321–340, 1974.Google Scholar
  83. 83.
    Pharoah POD, Alberman E, Doyle P, Chamberlain G: Outcome of pregnancy among women in anaesthetic practice. Lancet I:34–35, 1977.Google Scholar
  84. 84.
    Csaba IF, Sulyok E, Ertl T: Relationship of maternal treatment with indomethacin to persistence of fetal circulation syndrome. J Pediatr 92:484–485, 1978.PubMedGoogle Scholar
  85. 85.
    Atad J, Lindenbaum E, Arodi J, Bard D, David A: Fetal cardiovascular changes due to maternal indomethacin treatment. Isr J Med Sci 14:890, 1978.Google Scholar
  86. 86.
    Weinstein MR, Goldfield MD: Cardiovascular malformations with lithium use during pregnancy. Am J Psychiatry 132:529–531, 1975.PubMedGoogle Scholar
  87. 87.
    Källén B, Tandberg A: Lithium and pregnancy — A cohort study on manic-depressive women. Acta Psychiatr Scand 68:134–139, 1983.PubMedGoogle Scholar
  88. 88.
    Rane A, Tomson G, Bjarke B: Effects of maternal lithium therapy in a newborn infant. J Pediatr 93:296–298, 1978.PubMedGoogle Scholar
  89. 89.
    Arnon RG, Marin-Garcia J, Peeden JN: Tricuspid valve regurgitation and lithium carbonate toxicity in a newborn infant. Am J Dis Child 135:941–943, 1981.PubMedGoogle Scholar
  90. 90.
    Allan LD, Desai G, Tynan MJ: Prenatal echocardiographic screening for Ebstein’s anomaly for mothers on lithium therapy. Lancet 2:875–876, 1982.PubMedGoogle Scholar
  91. 91.
    Filtenborg JA: Persistent pulmonary hypertension after lithium intoxication in the newborn. Eur J Pediatr 138:321–323, 1982.PubMedGoogle Scholar
  92. 92.
    Slone D, Siskind V, Heinonen OP, Monson RR, Kaufman DW, Shapiro S: Antenatal exposure to phenothiazines in relation to congenital malformations, perinatal mortality rate, birth weight and intelligence quotient score. Am J Obstet Gynecol 128:486–488, 1977.PubMedGoogle Scholar
  93. 93.
    Milkovich L, Van den Berg BJ: An evaluation of the teratogenicity of certain antinauseant drugs. Am J Obstet Gynecol 125:244–248, 1976.PubMedGoogle Scholar
  94. 94.
    Turner G, Collins E: Fetal effects of regular salicylate ingestion in pregnancy. Lancet 2:338–339, 1975.PubMedGoogle Scholar
  95. 95.
    McNiel JR, Dodge F: The possible teratogenic effect of salicylates on the developing fetus. Clin Pediatr 12:347–350, 1973.Google Scholar
  96. 96.
    Monnet P, Kalb JC, Pujol M: Doit-on craindre une influence tératogène éventuelle de l’isoniazide? Rev Tuberc 31:845–848, 1967.Google Scholar
  97. 97.
    Coetzee EJ, Jackson WPU: Pregnancy in established non-insulin-dependent diabetics. A five-and-a-half year study of Groote Schuur hospital. S Afr Med J 58:795–802, 1980.PubMedGoogle Scholar
  98. 98.
    Hussain MA: Nutrient reserve in congenital malformations. Bangladesh Med Res Counc Bull 3:94–100, 1977.Google Scholar
  99. 99.
    Forbes GB: Vitamin-D in pregnancy and the infantile hypercalcemic syndrome. Pediatr Res 13:1382, 1979.PubMedGoogle Scholar
  100. 100.
    Russell JA, Powles RL, Oliver RTD: Conception and congenital abnormalities after chemotherapy of acute myelogenous leukaemia in two men. Br Med J I:1508, 1976.Google Scholar
  101. 101.
    Rosa FW: Birth defects with maternal exposure to the vitamin A congener, isoretinoin. J Clin Dysmorphol 2:13–17, 1984.Google Scholar
  102. 102.
    Nora JJ, Nora AH, Way GL: Cardiovascular maldevelopment associated with maternal exposure to amantadine. Lancet 2:607, 1975.PubMedGoogle Scholar
  103. 103.
    Abramovici A, Abramovici I, Kalman G, Liban E: Teratogenic effect of chlorimipramine in a young human embryo. Teratology 24:42A, 1981.Google Scholar
  104. 104.
    Ylikorkala O: Congenital anomalies and clomiphene. Lancet 2:1262, 1975.PubMedGoogle Scholar
  105. 105.
    Harpey JP, Darbois Y, Lefebvre G: Teratogenicity of pyrimethamine. Lancet 2:399, 1983.PubMedGoogle Scholar
  106. 106.
    Levin DL, Fixler DE, Morriss FC, Tyson J: Morphologic analysis of pulmonary vascular bed in infants exposed in utero to prostaglandin synthetase inhibitors. J Pediatr 92:478–484, 1978.PubMedGoogle Scholar
  107. 107.
    Corcoran R, Castles JM: Tetracycline for acne vulgaris and possible teratogenesis. Br Med J II:807, 1977.Google Scholar
  108. 108.
    Cox DR, Martin L, Hall BD: Asplenia syndrome after fetal exposure to warfarin. Lancet 2:1134, 1977.PubMedGoogle Scholar
  109. 109.
    Australian National Perinatal Statistic Unit — Sydney: Reports of suspected adverse drug reactions. Congenital Malformations Monitoring Report 4:3–6, 1981.Google Scholar
  110. 110.
    Fisher NL, Smith DW: Occipital encephalocele and early gestational hyperthermia. Pediatrics 68:480–483, 1981.PubMedGoogle Scholar
  111. 111.
    Smithells RW, Sheppard S: Teratogenicity testing in humans: A method demonstrating safety of bendectin. Teratology 17:31–36, 1978.PubMedGoogle Scholar
  112. 112.
    Gibson GT, Colley DP, McMichael AJ, Hartshorne JM: Congenital anomalies in relation to the use of doxylamine/dicyclomine and other antenatal factors. Med J Aust 1:410–414, 1981.PubMedGoogle Scholar
  113. 113.
    Fleming DM, Knox JDE, Crombie DL: Debendox in early pregnancy and fetal malformation. Br Med J II:99–101, 1981.Google Scholar
  114. 114.
    Shapiro S, Heinonen OP, Siskind V, Kaufman DW, Monson RR, Slone D: Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (bendectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. Am J Obstet Gynecol 128:480–485, 1977.PubMedGoogle Scholar
  115. 115.
    Michaelis J, Glueck E, Michaelis H: Teratogene Effekte von Lenotan? Dtsch Arzt Z 23:1527–1529, 1980.Google Scholar
  116. 116.
    Bunde CA, Bowles DM: A technique for controlled survey of case records. Curr Ther Res 5:245–248, 1963.PubMedGoogle Scholar
  117. 117.
    Morelock S, Hingson R, Kayne H, Dooling E, Zuckerman B, Day N, Alpert JJ, Flowerdew G: Bendectin and fetal development. A study at Boston City Hospital. Am J Obstet Gynecol 142:209–213, 1982.PubMedGoogle Scholar
  118. 118.
    Rothman KJ, Fyler DC, Goldblatt A, Kreidberg MB: Exogenous hormones and other drug exposures of children with congenital heart disease. Am J Epidemiol 109:433–439, 1979.PubMedGoogle Scholar
  119. 119.
    Mitchell AA, Rosenberg L, Shapiro S, Stone D: Birth defects related to bendectin use in pregnancy. I. Oral clefts and cardiac defects. JAMA 245:2311–2314, 1981.PubMedGoogle Scholar
  120. 120.
    Cordero JF, Oakley GP, Greenberg F, James LM: Is Bendectin a teratogen? JAMA 245:2307–2310, 1981.PubMedGoogle Scholar
  121. 121.
    Mitchell AA, Schwingl PJ, Rosenberg L, Lovik C, Shapiro S: Birth defects in relation to bendectin use in pregnancy. II. Pyloric stenosis. Am J Obstet Gynecol 147:737–742, 1983.PubMedGoogle Scholar
  122. 122.
    Bracken MB, Berg A: Bendectin (debendox) and congenital diaphragmatic hernia. Lancet 1:586, 1983.PubMedGoogle Scholar
  123. 123.
    Aselton P, Jick H, Chentow SJ, Perera DR, Hunter JR, Rothman KJ: Pyloric stenosis and maternal Bendectin exposure. Am J Epidemiol 120:251–256, 1984.PubMedGoogle Scholar
  124. 124.
    Laboratoris Sauter (Vernier-Genève): Bilan des effets tératogènes du „Tigason“ et du „Roaccutane.“ Circular letter to physicians from 07/27/1983.Google Scholar
  125. 125.
    Happle R, Traupe H, Bounameaux Y, Fisch T: Teratogenicity of etretinate in humans. Dtsch Med Wochenschr 109:1476–1480, 1984.PubMedGoogle Scholar
  126. 126.
    Rosa FW: Teratogenicity of isotretinoin. Lancet 2:513, 1983.PubMedGoogle Scholar
  127. 127.
    Stern R, Rosa F, Baum C: Isotretinoin and pregnancy. J Am Acad Dermatol 10:851–854, 1984.PubMedGoogle Scholar
  128. 128.
    Braun JT, Franciosi RA, Mastri AR, Drake RM, O’Neil BL: Isotretinoin dysmorphic syndrome. Lancet 1:506–507, 1984.PubMedGoogle Scholar
  129. 129.
    Delacruz E, Sun S, Vanguanichyakorn K, Desposito F: Multiple congenital malformations associated with maternal isotretinoin therapy. Pediatrics 74:428–430, 1984.Google Scholar
  130. 130.
    Beneke PJ: The isotretinoin teratogen syndrome. JAMA 251:3267–3269, 1984.Google Scholar
  131. 131.
    Hill RM: Isotretinoin teratogenicity. Lancet 1:1465, 1984.PubMedGoogle Scholar
  132. 132.
    Bernhardt IB, Dorsey DJ: Hypervitaminosis and congenital renal anomalies in a human infant. Obstet Gynecol 43:750–755, 1974.PubMedGoogle Scholar
  133. 133.
    Mounoud RL, Klein D, Weber F: Acute vitamin-A intoxication in a mother during pregnancy. J Genet Hum 23:135–154, 1975.PubMedGoogle Scholar
  134. 134.
    Staenge L, Carlstrom E, Eriksson M: Hypervitaminosis A in early human pregnancy and malformations of the central nervous system. Acta Obstet Gynecol Scand 57:289–291, 1978.Google Scholar
  135. 135.
    Gal I, Sharman IM, Pryse-Davies J: Vitamin A in relation to human congenital malformations. Adv Teratol 5:143–158, 1972.Google Scholar
  136. 136.
    Kolata GB: How safe is bendectin? Science 210:518–519, 1980.PubMedGoogle Scholar
  137. 137.
    Holmes LB: Teratogen update: Bendectin. Teratology 27:277–281, 1983.PubMedGoogle Scholar
  138. 138.
    Brent RL: The bendectin saga: Another American tragedy. Teratology 27:283–286, 1983.PubMedGoogle Scholar
  139. 139.
    Mitchell AA: Bendectin teratogenicity: Human studies. Teratology 29:46A, 1984.Google Scholar
  140. 140.
    Golding J, Baldwin JA: Clefts of lip and palate and maternal drug consumption. I. Antinauseants. Read before FDA Fertility and Maternal Health Drugs Advisory Committee, Washington, D.C., Sept. 15, 1980.Google Scholar
  141. 141.
    David TJ: Debendox does not cause the Poland anomaly. Arch Dis Child 57:479–480, 1982.PubMedGoogle Scholar
  142. 142.
    Donnai D, Harris R: Unusual fetal malformations after antiemetics in early pregnancy. Br Med J I:691–692, 1978.Google Scholar
  143. 143.
    Grodofsky MB, Wilmott RW: Possible association of use of bendectin during early pregnancy and congenital lung hypoplasia. N Engl J Med 311:732, 1984.PubMedGoogle Scholar
  144. 144.
    Mellor S: Fetal malformation after debendox treatment in early pregnancy. Br Med J I:1055, 1978.Google Scholar
  145. 145.
    Smithells RW, Sheppard S: Teratogenicity of debendox and pyrimethamine. Lancet 2:623–624, 1983.PubMedGoogle Scholar
  146. 146.
    Little WA: Bendectin: The clinical experience. Teratology 29:44A, 1984.Google Scholar
  147. 147.
    Löser H, Apitz J, Majewski F: Cardiovascular malformations in embryofetal alcohol syndrome. Eur J Cardiol 5:303–304, 1977.Google Scholar
  148. 148.
    Hinckers HJ: The influences of alcohol on the fetus. J Perinat Med 6:3–14, 1978.PubMedGoogle Scholar
  149. 149.
    Crepin G, Dehaene P: Le nouveau-né de mère alcoohque, signes cliniques, devenir. In: Société Francaise de Médecine Périnatale, 10èmes Journées Nationales, Deauville 1980, Paris, Librairie Arnette, 1981, p 205–214.Google Scholar
  150. 150.
    Löser H: Human alcohol embryopathy and changes at the cardiovascular system. Teratology 24:29A–30A, 1981.Google Scholar
  151. 151.
    Smith DF, Sandor GG, MacLeod PM, Tredwell S, Wood B, Newman DE: Intrinsic defects in the fetal alcohol syndrome: Studies on 76 cases from British Columbia and the Yukon Territory. Neurobehav Toxicol Teratol 3:145–152, 1981.PubMedGoogle Scholar
  152. 152.
    Golden NL, Sokol RJ, Kuhnert BR, Bottoms S: Maternal alcohol use and infant development. Pediatrics 70:931–934, 1982.PubMedGoogle Scholar
  153. 153.
    Flynn A, Miller SI, Martier S, Golden N, Sokol RJ, DelVillano BC: Zinc status of pregnant alcoholic women: A determinant of fetal outcome. Lancet 1:572–574, 1981.PubMedGoogle Scholar
  154. 154.
    Tredwell SJ, Smith DF, MacLeod PJ, Wood BJ: Cervical spine anomalies in fetal alcohol syndrome. Spine 7:331–334, 1982.PubMedGoogle Scholar
  155. 155.
    Lipson A, Walsh D, Webster W: Fetal alcohol syndrome. A great paediatric imitator. Med J Aust 1:266–269, 1983.PubMedGoogle Scholar
  156. 156.
    Ferrier PE: Alcoholic embryopathy — Epidemiology, clinical treatment, prevention. In: Alcohol and youth. Child health and development, Second Volume, Jeanneret O (ed), Basel, S. Karger AG, 1983, p 14–22.Google Scholar
  157. 157.
    Spohr HL, Stoltenberg-Didinger G: Zum Problem der „abortiven“ Alkoholembryopathie. Monatsschr Kinderheilkd 131:96–99, 1983.PubMedGoogle Scholar
  158. 158.
    Majewski F: Alcohol embryopathy: Some facts and speculations about pathogenesis. Neurobehav Toxicol Teratol 3:129–144, 1981.PubMedGoogle Scholar
  159. 159.
    Sandor GGS, Smith DF, MacLeod PM: Cardiac malformations in the fetal alcohol syndrome. J Pediatr 98:771–773, 1981.Google Scholar
  160. 160.
    Nestler V, Spohr HL, Steinhausen HC: Alkoholembryopathie — Mehrdimensionale Studien zu den Folgen des Alkoholismus in der Schwangerschaft. Stuttgart, Enke, 1981.Google Scholar
  161. 161.
    Majewski F, Bierich JR, Löser H, Michaelis R, Leiber B, Bettecken F: Clinical aspects of pathogenesis of alcohol embryopathy. München Med Wochenschr 118:1635–1642, 1976.Google Scholar
  162. 162.
    Olegard R, Sobel KG, Aronsson M, Sandin B, Johansson PR, Carlsson C, Kyllerman M, Iversen K, Hebek A: Effects on the child of alcohol abuse during pregnancy. Retrospective and prospective studies. Acta Paediatr Scand 275(Suppl 0):112–121, 1979.Google Scholar
  163. 163.
    Dupuis C, Dehaene P, Deroubaix-Tella P, Blanc-Garin AP, Rey C, Carpentier-Courault C: Cardiac disease in children born of alcoholic mothers. Arch Mal Coeur 71:565–572, 1978.Google Scholar
  164. 164.
    Hanson JW, Jones KL, Smith DW: Fetal alcohol syndrome. JAMA 235:1458–1460,1976.PubMedGoogle Scholar
  165. 165.
    Beattie JO, Day RE, Cockburn F, Garg RA: Alcohol and the fetus in the West of Scotland. Br Med J I:17–20, 1983.Google Scholar
  166. 166.
    Löser H, Majewski F, Apitz J, Bierich J: Cardiovascular malformations in embryofetal alcohol syndrome. Klin Pädiatr 188:233–240, 1976.PubMedGoogle Scholar
  167. 167.
    Löser H, Majewski F: Type and frequency of cardiac defects in embryofetal alcohol syndrome. Report of 16 cases. Br Heart J 39:1374–1380, 1977.PubMedGoogle Scholar
  168. 168.
    Turner EK: Fetal alcohol syndrome. Med J Aust 1:178, 1979.PubMedGoogle Scholar
  169. 169.
    Jones KL, Smith DW, Hanson JW: The fetal alcohol syndrome: Clinical delineation. Ann NY Acad Sci 273:130–137, 1976.PubMedGoogle Scholar
  170. 170.
    Mulvihill JJ, Klimas JT, Stokes DC, Risemberg HM: Fetal alcohol syndrome: Seven new cases. Am J Obstet Gynecol 125:937–941, 1976.PubMedGoogle Scholar
  171. 171.
    Qazi Q, Masakawa A, Milman D, McGann B, Chua A, Haller J: Renal anomalies in fetal alcohol syndrome. Pediatrics 63:886–889, 1979.PubMedGoogle Scholar
  172. 172.
    Ijaiya K, Schwenk A, Gladtke E: Fetales Alkoholsyndrom. Dtsch Med Wochenschr 101:1563–1568, 1976.PubMedGoogle Scholar
  173. 173.
    Van Biervliet JP: The foetal alcohol syndrome. Acta Padiatr Belg 30:113–116, 1977.Google Scholar
  174. 174.
    Walters RM: Alcohol and advice to the pregnant women. Br Med J I:640, 1983.Google Scholar
  175. 175.
    Janz D, Fuchs U: Sind epileptische Medikamente während der Schwangerschaft schädlich? Dtsch Med Wochenschr 89:241–243, 1964.PubMedGoogle Scholar
  176. 176.
    Deblay MF, Vert P, Andre M: Children of epileptic mothers. Nouv Presse Med 11:173–176, 1982.PubMedGoogle Scholar
  177. 177.
    Annegers JF, Hauser WA, Elveback LR, Anderson VE, Kurland LI: Congenital malformations and seizure disorders in the offspring of parents with epilepsy. Int J Epidemiol 7:241–247, 1978.PubMedGoogle Scholar
  178. 178.
    Giraud JR, Hoppeler JM, Mettey R, Fizazi T, DeTourris H, Colasson F: Risques tératogènes des traitements anti-épileptiques. J Gynecol Obstet Biol Reprod 11:385–391, 1982.Google Scholar
  179. 179.
    Rating D, Jäger-Roman E, Koch S, Göpfert-Geyer I, Helge H: Minor anomalies in the offspring of epileptic parents. In: Epilepsy, pregnancy, and the child, Janz D, Dam M, Richens A, Bossi L, Helge H, Schmidt D (eds), New York, Raven Press, 1982, p 283–288.Google Scholar
  180. 180.
    Robert E, Rosa FW, Robert JM: Maternal anti-epileptic exposure rates for spina bifida, heart defects, facial cleft outcomes compared to other defect outcomes in Lyon birth defect registry. Teratology, in press, 1984.Google Scholar
  181. 181.
    Meadow SR: Anticonvulsant drugs and congenital abnormalities. Lancet 2:1296, 1968.PubMedGoogle Scholar
  182. 182.
    Starreveld-Zimmerman AAE, Van der Kolk WJ, Elshove J, Meinardi H: Teratogenicity of antiepileptic drugs. Clin Neurol Neurosurg 2: 81–95, 1974.Google Scholar
  183. 183.
    Speidel BD, Meadow SR: Maternal epilepsy and abnormalities of the fetus and newborn. Lancet 2:839–843, 1972.PubMedGoogle Scholar
  184. 184.
    Meyer JG: The teratological effects of anticonvulsants and the effects on pregnancy and birth. Eur Neurol 10:179–190, 1973.PubMedGoogle Scholar
  185. 185.
    Annegers JF, Kurland LT, Elveback LR: Epilepsy, anticonvulsants and congenital malformations. In: Transactions of the American Neurological Association 1974, Vol. 99, Trufant SA (ed), New York, Springer Publishing Co., 1975, p 184–186.Google Scholar
  186. 186.
    Annegers JF, Elveback LR, Hauser WA, Kurland LT: Do anticonvulsants have a teratogenic effect? Arch Neurol 31:364–373, 1974.PubMedGoogle Scholar
  187. 187.
    Koch S, Göpfert-Geyer I, Jäger-Roman E, Jakob S, Huth H, Hartmann A, Rating D, Helge H: Anticonvulsants during pregnancy. Dtsch Med Wochenschr 108:250–256, 1983.PubMedGoogle Scholar
  188. 188.
    Dieterich E, Steveling A, Lukas A, Seyfeddinipur N, Spranger J: Congenital anomalies in children of epileptic mothers and fathers. Neuropediatrics 11:274–283, 1980.PubMedGoogle Scholar
  189. 189.
    Hill RM, Verniaud W, Horning MG, McCulley LB, Morgan NF: Infants exposed in utero to antiepileptic drugs. Am J Dis Child 127:645–656, 1974.PubMedGoogle Scholar
  190. 190.
    Rosa FW: Pregnancy outcomes with maternal carbamazepine exposure. ADR Highlights 83-11, Rockville, FDA, 1983.Google Scholar
  191. 191.
    Speidel BD, Meadow SR: Epilepsy, anticonvulsant and congenital malformations. Drugs 8:354–365, 1974.PubMedGoogle Scholar
  192. 192.
    Thomas D, Buchanan N: Teratogenic effects of anticonvulsants. J Pediatr 99:163, 1981.PubMedGoogle Scholar
  193. 193.
    Monson RR, Rosenberg L, Hartz SC, Shapiro S, Heinonen OP, Slone D: Diphenylhydantoin and selected congenital malformations. N Engl J Med 289:1049–1052, 1973.PubMedGoogle Scholar
  194. 194.
    Biale Y, Lewenthal H, Aderet NB: Congenital malformations due to anticonvulsive drugs. Obstet Gynecol 45:439–442, 1975.PubMedGoogle Scholar
  195. 195.
    Char F, Hearty JB, Dungan WT: Patterns of malformations in infants exposed to gestational anticonvulsants. In: Exc Med Internat Ser 426, Littlefield JW (ed), Baltimore, Excerpta Medica, 1977, p 84.Google Scholar
  196. 196.
    Schinzel AA: Fetal hydantoin syndrome in siblings. Schweiz Med Wochenschr 109:68–72, 1979.PubMedGoogle Scholar
  197. 197.
    Truog WE, Feusner JH, Baker DL: Association of hemorrhagic disease and the syndrome of persistent fetal circulation with the fetal hydantoin syndrome. J Pediatr 96:112–113, 1980.PubMedGoogle Scholar
  198. 198.
    Bartoshesky LE, Bhan I, Nagpaul K, Pashayan H: Severe cardiac and ophthalmologic malformations in an infant exposed to diphenylhydantoin in utero. Pediatrics 69:202–203, 1982.PubMedGoogle Scholar
  199. 199.
    Taylor WF, Myers M, Taylor WR: Extrarenal Wilms tumor in an infant exposed to intrauterine phenytoin. Lancet 2:481, 1980.PubMedGoogle Scholar
  200. 200.
    Wilker R, Nathenson G: Combined fetal alcohol and hydantoin syndromes. Clin Pediatr 21:331–334, 1982.Google Scholar
  201. 201.
    Seeler RA, Israel JN, Royal JE, Kaye CI, Rao S, Abulaban M: Ganglioneuroblastoma and fetal hydantoin-alcohol syndromes. Pediatrics 63:524–527, 1979.PubMedGoogle Scholar
  202. 202.
    Wood BP, Young LW: Pseudohyperphalangism in fetal dilantin syndrome. Radiology 131:371–372, 1979.PubMedGoogle Scholar
  203. 203.
    Dabee V, Hart AG, Hurley RM: Teratogenic effects of diphenylhydantoin. Can Med Assoc J 112:75–77, 1975.PubMedGoogle Scholar
  204. 204.
    Allen RW Jr, Ogden B, Bentley FL, Jung AL: Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate. JAMA 244:1464–1465, 1980.PubMedGoogle Scholar
  205. 205.
    Lowe CR: Congenital malformations among infants born to epileptic women. Lancet 1: 9–10, 1973.PubMedGoogle Scholar
  206. 206.
    Hoyt CS, Bilsson FA: Maternal anticonvulsants and optic nerve hypoplasia. Br J Opbthalmol 62:3–7, 1978.Google Scholar
  207. 207.
    Pellock JM, Flannery DB, Mamunes P, Robertson LW: The fetal primidone syndrome. Ann Neurol 12:209, 1982.Google Scholar
  208. 208.
    Rating D, Nau H, Jäger-Roman E, Göpfert-Geyer I, Koch S, Beck-Mannagetta G, Schmidt D, Helge H: Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women. Acta Paediatr Scand 71:301–312, 1982.PubMedGoogle Scholar
  209. 209.
    German JA, Kowal A, Ehlers K: Trimethadione and human teratogenesis. Teratology 3:349–362, 1970.PubMedGoogle Scholar
  210. 210.
    Nichols MM: Fetal anomalies following maternal trimethadione ingestion. J Pediatr 82:885–886, 1973.PubMedGoogle Scholar
  211. 211.
    Feldman GL, Weaver DD, Lovrien EW: Fetal trimethadione syndrome — Report of an additional family and further delineation of this syndrome. Am J Dis Child 131:1389–1402, 1977.PubMedGoogle Scholar
  212. 212.
    Nau H, Rating D, Koch S, Hauser I, Helge H: Valproic acid and its metabolites — Placental transfer, neonatal pharmacokinetics, transfer via mothers milk and clinical status in neonates of epileptic mothers. J Pharmacol Exp Ther 219:768–777, 1981.PubMedGoogle Scholar
  213. 213.
    Kučera J: Rate and type of congenital anomalies among offspring of diabetic women. J Reprod Med 7:61–70, 1971.Google Scholar
  214. 214.
    Pederson LM, Tygstrup I, Pederson J: Congenital malformations in newborn infants of diabetic women. Lancet 1:1124, 1964.Google Scholar
  215. 215.
    Malins JM: Congenital malformations and fetal mortality in diabetic pregnancy. J R Soc Med 71:205–206, 1978.PubMedGoogle Scholar
  216. 216.
    Soler NG: Diabetic pregnancy and congenital malformations. In: Perinatal medicine, Fifth European Congress Uppsala, Rooth G, Bratteby LE (eds), Stockholm, Almqvist & Wiksell Int., 1976, p 108–111.Google Scholar
  217. 217.
    Goodman MJ: Maternal diabetes and congenital malformations among live births in Hawaii. Acta Diabetol Lat 13:99–106, 1976.PubMedGoogle Scholar
  218. 218.
    Rowland TW, Hubbell JP, Nadas AS: Congenital heart disease in infants of diabetic mothers. J Pediatr 83:815–820, 1973.PubMedGoogle Scholar
  219. 219.
    Fuhrmann K, Reiher H, Semmler K, Fischer F, Fischer M, Glockner E: Prevention of congenital malformations in infants of insulin-dependent diabetic mothers. Diabetes Care 6:219–223, 1983.PubMedGoogle Scholar
  220. 220.
    Artner J, Irsigler K, Ogris E, Rosenkranz A: Diabetes and pregnancy. Arch Gynecol 232:367–386, 1981.Google Scholar
  221. 221.
    Gamsu HR: Neonatal morbidity in infants of diabetic mothers. J R Soc Med 71:211–222, 1978.PubMedGoogle Scholar
  222. 222.
    Barbarani V, Penneff P, Cattaneo F, Vitali S, Marini A: Les nouveaunés de mère diabétique dont le diabète fut strictement contrôlé durant la grossesse (Résultats cliniques dans 476 cas). Rev Med Suisse Romande 98:259–267, 1978.PubMedGoogle Scholar
  223. 223.
    Lemons JA, Vargas P, Delaney JJ: Infant of the diabetic mother: Review of 225 cases. Obstet Gynecol 57:187–192, 1981.PubMedGoogle Scholar
  224. 224.
    Temesio P, Belitzky R, Gallego L, Martell M, Pose SV: Congenital malformations in diabetic offspring. Acta Diabetol Lat 14:192–198, 1977.PubMedGoogle Scholar
  225. 225.
    Cruveiller J, Veron P, Benichou JE: Diabetic embryopathy. Report of hundred cases. Semaine Hop Paris 53:2317–2327, 1977.Google Scholar
  226. 226.
    Heinonen OP: Risk factors for congenital heart disease; A prospective study. In: Birth defects, risks and consequences, Kelly S, Hook EB, Janerich DT (eds), New York, Academic Press, 1976, p 221–264.Google Scholar
  227. 227.
    Gutgesell HP, Speer ME, Rosenberg HS: Characterization of the cardiomyopathy in infants of diabetic mothers. Circulation 61:441–450, 1980.PubMedGoogle Scholar
  228. 228.
    Dunn V, Nixon GW, Jaffe RB, Condon VR: Infants of diabetic mothers — Radiographic manifestations — Review. Am J Roentgenol 137:123–128, 1981.Google Scholar
  229. 229.
    Wolfe RR, Way GL: Cardiomyopathies in infants of diabetic mothers. Johns Hopkins Med J 140:177–180, 1977.PubMedGoogle Scholar
  230. 230.
    Herre HD, Horky Z: Die Missbildungsfrequenz bei Kindern diabetischer Mütter. Zentralbl Gynäkol 86:758–768, 1964.PubMedGoogle Scholar
  231. 231.
    Trowitzsch E, Bigalke U, Gisbertz R, Kallfelz HC: The heart in infants of diabetic mothers — An echocardiographic study. Eur J Pediatr 135:336, 1981.Google Scholar
  232. 232.
    Johnson JP, Fineman RM: Branchial arch malformations in infants of diabetic mothers: Two case reports and a review. Am J Med Genet 13:125–130, 1982.PubMedGoogle Scholar
  233. 233.
    Weber M, Schweitzer M, Mur JM, Andre JM, Tridon P, Vert P: Epilepsy, anticonvulsants and pregnancy. Arch Fr Pediatr 34:374–383, 1977.PubMedGoogle Scholar
  234. 234.
    Fraser FC, Metrakos JD, Zlatkin M: Is the epileptic genotype teratogenic? Lancet 1:884–885, 1978.PubMedGoogle Scholar
  235. 235.
    Annegers JF, Elveback LR, Hauser WA, Kurland LT: Epilepsy anticonvulsants and malformations. In: New chromosomal and malformation syndromes, Bergsma D (ed), New York, Stratton Intercontinental Medical Book Corp., 1974, p 157–160.Google Scholar
  236. 236.
    Monson RR, Heinonen OP, Shapiro S, Slone D: Diphenylhydantoin and epilepsy in relation to congenital malformations and mental development. Am J Epidemiol 100:509, 1974.Google Scholar
  237. 237.
    Cordero JF, Oakley GP Jr: Drug exposure during pregnancy: Some epidemiologic considerations. Clin Obstet Gynecol 26:418–428, 1983.PubMedGoogle Scholar
  238. 238.
    Lindhout D, Meinerdi H, Barth PG: Hazards of fetal exposure to drug combinations. In: Epilepsy, pregnancy, and the child, Janz D, Dam M, Richens A, Bossi L, Helge H, Schmidt D (eds), New York, Raven Press, 1982, p 275–281.Google Scholar
  239. 239.
    Hiilesmaa VK, Teramo K, Granström ML, Bardy AH: Fetal head growth retardation associated with maternal antiepileptic drugs. Lancet 2:165–166, 1981.PubMedGoogle Scholar
  240. 240.
    Hanson JW, Smith DW: Fetal hydantoin syndrome. J Pediatr 87:285–290, 1975.PubMedGoogle Scholar
  241. 241.
    Bjerkedal T, Czeizel A, Goujard J, Kallen B, Mastroiacova P, Nevin N, Oakley G Jr, Robert E: Valproic acid and spina bifida. Lancet 2:1096, 1982.PubMedGoogle Scholar
  242. 242.
    CDC: Valproic acid and spina bifida — A preliminary report — France. CDC: Morbidity and Mortality Weekly Report 31:565–566, 1982.Google Scholar
  243. 243.
    CDC: Valproate: A new cause of birth defects — Report from Italy and follow-up from France. CDC: Morbidity and Mortality Weekly Report 32:438–439, 1983.Google Scholar
  244. 244.
    Robert E: Valproic acid in pregnancy — Association with spina bifida: A preliminary report. Clin Pediatr 22:336, 1983.Google Scholar
  245. 245.
    Robert E, Guibaud P: Maternal valproic acid and congenital neural tube defects. Lancet 2:937, 1982.PubMedGoogle Scholar
  246. 246.
    Alberman E, Pharoah P, Chamberlain G, Roman E, Evans S: Outcome of pregnancies following the use of oral contraceptives. Int J Epidemiol 9:207–214, 1980.PubMedGoogle Scholar
  247. 247.
    Redline RW, Abramowsky CR: Transposition of the great vessels in an infant exposed to massive doses of oral contraceptives. Am J Obstet Gynecol 141:468–469, 1981.PubMedGoogle Scholar
  248. 248.
    Cosgrove MD, Benton B, Henderson BE: Male genitourinary abnormalities and maternal diethylstilbestrol. J Urol 117:220–223, 1977.Google Scholar
  249. 249.
    Nora JJ, Nora AH: Birth defects and oral contraceptives. Lancet 1:941–942, 1973.PubMedGoogle Scholar
  250. 250.
    Nora JJ, Nora AH: Congenital abnormalities and first trimester exposure to progestagenestrogen. Lancet I:313–314, 1976.Google Scholar
  251. 251.
    Kauppila A, Hartikainen-Sorri AL, Koivisto M, Ryhänen P: Cell mediated immunocompetence of children exposed in utero to short- or long- term action of glucocorticoids. Gynecol Obstet Invest 15:41–48, 1983.PubMedGoogle Scholar
  252. 252.
    Day RE, Insley J: Maternal diabetes mellitus and congenital malformation: Survey of 205 cases. Arch Dis Child 51:935–939, 1976.PubMedGoogle Scholar
  253. 253.
    Haukkamaa M, Nilsson CG, Luukkainen T: Screening, management and outcome of pregnancy in diabetic mothers. Obstet Gynecol 55:596–602, 1980.PubMedGoogle Scholar
  254. 254.
    Tripodi V, Raucci F, Russo N, Verolino A: Malformations of the urogenital system in a newborn girl of a diabetic mother: Report of a clinical case. Pediatria 86:499–506, 1978.PubMedGoogle Scholar
  255. 255.
    Janerich DT, Dugan JM, Standfast SJ, Strite L: Congenital heart disease and prenatal exposure to exogenous sex hormones. Br Med J I:1058–1060, 1977.Google Scholar
  256. 256.
    Mulvihill JJ, Mulvihill CG, Neill CA: Prenatal sex-hormone exposure and cardiac defects in man. Teratology 9:30A, 1974.Google Scholar
  257. 257.
    Herbst AL, Bern HA (eds): Developmental effects of diethylstilbestrol (DES) in pregnancy. New York, Thieme-Stratton Inc., 1981.Google Scholar
  258. 258.
    Nora AH, Nora JJ: A syndrome of multiple congenital anomalies associated with teratogenic exposure. Arch Environ Health 30:17–21, 1975.PubMedGoogle Scholar
  259. 259.
    Ferencz C: Teratogenicity of progestational agents: Response to the Drs. Nora. Teratology 29:135–136, 1984.Google Scholar
  260. 260.
    Nora JJ: Teratogenicity of progestational agents: Comments on Dr. Schardein’s paper. Teratology 29:139–143, 1984.Google Scholar
  261. 261.
    Nora JJ, Nora AH: Teratogenicity of progestational agents: Comments on Dr. Ferencz’s paper. Teratology 29:133–134, 1984.Google Scholar
  262. 262.
    Oakley GP Jr: Comment: Teratogenicity of progestational agents. Teratology 29:131, 1984.Google Scholar
  263. 263.
    Wilson PD: Sample size and power in case-control studies: Response to the Drs. Nora. Teratology 29:137–138, 1984.Google Scholar
  264. 264.
    Ferencz C, Matanoski GM, Wilson PD, Rubin JD, Neill CA, Gutberlet R: Maternal hormone therapy and congenital heart disease. Teratology 21:225–239, 1980.PubMedGoogle Scholar
  265. 265.
    Nora JJ, Nora AH, Blu J, Ingram J, Fountain A, Peterson M, Lortscher RM, Kimberling WJ: Exogenous progestogen and estrogen implicated in birth defects. JAMA 240:837–843, 1978.PubMedGoogle Scholar
  266. 266.
    Schardein JL: Teratogenicity of progestational agents: Response to Dr. Nora. Teratology 29:145–154, 1984.Google Scholar
  267. 267.
    Dickson D: Herbicide claimed responsible for birth defects. Nature 282:220, 1979.PubMedGoogle Scholar
  268. 268.
    Hall JG, McLaughlin JF, Stamm S: Coarctation of the aorta in male cousins with similar maternal environmental exposure to insect repellent and insecticides. Pediatrics 55:425–427, 1975.PubMedGoogle Scholar
  269. 269.
    Theriault G, Iturra H, Gingras S: Evaluation of the association between birth defects and exposure to ambient vinyl chloride. Teratology 27:359–370, 1983.PubMedGoogle Scholar
  270. 270.
    Hemminki K, Axelson O, Niemi ML, Ahlborg G: Assessment of methods and results of reproductive occupational epidemiology — Spontaneous abortions and malformations in the offspring of working women. In: Reproductive toxicology, Progr Clin Biol Res, vol. 117, Mattison DR (ed), New York, Alan R. Liss, Inc., 1983, p 293–308.Google Scholar
  271. 271.
    Infante PF, Tsongas TA: Occupational reproductive hazards: Necessary steps to prevention. Am J Ind Med 4:383–390, 1983.PubMedGoogle Scholar
  272. 272.
    Whorton MD: Adverse reproductive outcomes: The occupational health issue of the 1980s. Am J Public Health 73:15–16, 1983.PubMedGoogle Scholar
  273. 273.
    Saxena MC, Siddiqui MKJ, Seth TD, Krishna Murti CR, Bhargava AK, Kutty D: Organochlorine pesticides in specimens from women undergoing spontaneous abortion, premature or full-term delivery. J Anal Toxicol 5:6–9, 1981.PubMedGoogle Scholar
  274. 274.
    Kurppa K, Holmberg PC, Hernberg S, Rantala K, Riala R, Nurminen T: Screening for occupational exposures and congenital malformations. Preliminary results from a nationwide case-referent study. Scand J Work Environ Health 9:89–93, 1983.PubMedGoogle Scholar
  275. 275.
    Källén B, Malmquist G, Moritz U: Delivery outcome among physiotherapists in Sweden. Is non-ionizing radiation a fetal hazard? Arch Environ Health 37:81–84, 1982.PubMedGoogle Scholar
  276. 276.
    Nordstrom S, Birke E, Gustavsson L: Reproductive hazards among workers at high voltage substations. Bioelectromagnetics 4:91–101, 1983.PubMedGoogle Scholar
  277. 277.
    Clausen J, Bierring F: Fetal arterial involvement in Behcet’s disease. An electron microscope study. Acta Pathol Microbiol Immunol Scand A 91:133–136, 1983.PubMedGoogle Scholar
  278. 278.
    Brazy JE, Grimm JK, Little VA: Neonatal manifestations of severe maternal hypertension occurring before the 36th week of pregnancy. J Pediatr 100:265–271, 1982.PubMedGoogle Scholar
  279. 279.
    Lipson A, Beuhler B, Bartley J, Walsh D, Yu Y, O’Halloran M, Webster W: Maternal hyperphenylalaninemia fetal effects. J Pediatr 104:216–220, 1984.PubMedGoogle Scholar
  280. 280.
    Chameides L, Truex RC, Vetter V, Rashkind WJ, Galioto FM, Noonan JA: Association of maternal systemic lupus erythematosus and congenital complete heart block. N Engl J Med 297:1204–1207, 1977.PubMedGoogle Scholar
  281. 281.
    Fisch RO, Doeden D, Lansky LL, Anderson JA: Maternal phenylketonuria. Detrimental effects on embryogenesis and fetal development. Am J Dis Child 118:847–858, 1969.PubMedGoogle Scholar
  282. 282.
    Zaleski LA, Casey RE, Zaleski W: Maternal phenylketonuria: Dietary treatment during pregnancy. Can Med Assoc J 121:1591–1592, 1979.PubMedGoogle Scholar
  283. 283.
    Smith I, Erdohazi M, Macartney FJ, Pincott JR, Wolff OH, Brenton DP, Biddle SA, Fairweather DV: Fetal damage despite low-phenylalanine diet after conception in a phenylketonuric woman. Lancet 1:17–19, 1979.PubMedGoogle Scholar
  284. 284.
    Michels VV, Justice CL: Treatment of phenylketonuria during pregnancy. Clin Genet 21:141–144, 1982.PubMedGoogle Scholar
  285. 285.
    Lenke RR, Levy HL: Maternal phenylketonuria and hyperphenylalaninemia: An international survey of the outcome of untreated and treated pregnancies. N Engl J Med 303:1202–1208, 1980.PubMedGoogle Scholar
  286. 286.
    Levy HL, Waisbren SE: Effects of untreated maternal phenylketonuria and hyperphenylalaninemia on the fetus. N Engl J Med 309:1269–1274, 1983.PubMedGoogle Scholar
  287. 287.
    Ferencz C, Rubin JD, Klein S, McCarter RJ: Malformations in families of infants with congenital heart disease. Teratology 27:41A, 1983.Google Scholar
  288. 288.
    Yerushalmy J: Congenital heart disease and maternal smoking habits. Nature 242:262,1973.PubMedGoogle Scholar
  289. 289.
    Evans DR, Newcombe RG, Campbell H: Maternal smoking habits and congenital malformations: A population study. Br Med J II:171–172, 1979.Google Scholar
  290. 290.
    Himmelberger DU, Brown BW, Cohen EN: Cigarette smoking during pregnancy and occurrence of spontaneous abortion and congenital abnormality. Am J Epidemiol 108:470–479, 1978.PubMedGoogle Scholar
  291. 291.
    Christianson RE: The relationship between maternal smoking and the incidence of congenital anomalies. Am J Epidemiol 112:684–695, 1980.PubMedGoogle Scholar
  292. 292.
    Kullander S, Källén B: A prospective study of smoking and pregnancy. Acta Obstet Gynecol Scand 50:83–94, 1971.Google Scholar
  293. 293.
    Mau G, Netter P: Die Auswirkungen des väterlichen Zigarettenkonsums auf die perinatale Sterblichkeit und die Missbildungshäufigkeit. Dtsch Med Wochenschr 99:1113–1118, 1974.PubMedGoogle Scholar
  294. 294.
    Hardy J: Rubella as a teratogen. Birth Defects 7:64–71, 1971.PubMedGoogle Scholar
  295. 295.
    Jespersen CS, Littauer J, Sagild U: Measles as a cause of fetal defects. Acta Paediatr Scand 66:367–372, 1977.PubMedGoogle Scholar
  296. 296.
    Ueda K, Nishida Y, Oshima K, Yoshikawa H, Nonaka S: Explanation for high incidence of congenital rubella syndrome in Ryukyu. Am J Epidemiol 107:344–352, 1978.PubMedGoogle Scholar
  297. 297.
    Cooper L: Congenital rubella in the United States. In: Infections of the fetus and the newborn infant, Krugman S, Gershon A (eds), New York, Alan R. Liss, Inc., 1975, p 1–22.Google Scholar
  298. 298.
    Chess S, Fernandez P, Korn S: Behavioral consequences of congenital rubella. J Pediatr 93:699–703, 1978.PubMedGoogle Scholar
  299. 299.
    Miller E, Cradock-Watson JE, Pollock TM: Consequences of confirmed maternal rubella at successive stages of pregnancy. Lancet 2:781–784, 1982.PubMedGoogle Scholar
  300. 300.
    Isacsohn M, Nishmi M, Swartz TA: Rubella in Jerusalem. 2. Clinical and serologic findings in children with congenital rubella. Isr J Med Sci 15:17–22, 1979.PubMedGoogle Scholar
  301. 301.
    Murphy AM, Field PR, Collins E: The value of specific IgM tests in the early diagnosis of congenital rubella. Med J Aust 2:290–292,1978.Google Scholar
  302. 302.
    Horstmann DM: Discussion. Birth Defects 7:6–8, 1965.Google Scholar
  303. 303.
    Osterhammel D: Audiological findings in children with a congenital rubella syndrome. Scand Audiol (Suppl) 10:33–44, 1980.Google Scholar
  304. 304.
    Toendury G: Zur Kenntnis der Embryopathia rubeolica des Auges. Klin Monatsbl Augenheilkd 157:141–164, 1970.Google Scholar
  305. 305.
    Vince DJ: The hospital incidence and clinical significance of congenital heart malformations resulting from rubella embryopathy. Can Med Assoc J 102:274–276, 1970.Google Scholar
  306. 306.
    Wagner HR: Cardiac disease in congenital infections. Clin Perinatol 8:481–497, 1981.PubMedGoogle Scholar
  307. 307.
    Limbacher JP, Hill ME, Janicki PC: Hypoplasia of the abdominal aorta associated with rubella syndrome. South Med J 72:617–618, 1979.PubMedGoogle Scholar
  308. 308.
    Overall JC: Intrauterine virus infections and congenital heart disease. Am Heart J 84:828–833, 1972.Google Scholar
  309. 309.
    Bose CL, Gooch M, Sanders GO, Bucciarelli RL: Dissimilar manifestations of intrauterine infection with echovirus 11 in premature twins. Arch Pathol Lab Med 107:361–363, 1983.PubMedGoogle Scholar
  310. 310.
    Brown ZA, Stenchever MA: Infectious mononucleosis and congenital anomalies. Am J Obstet Gynecol 131:108, 1978.PubMedGoogle Scholar
  311. 311.
    Montgomery JR, Flanders W, Yow MD: Congenital anomalies and herpes virus infection. Am J Dis Child 126:364–366, 1973.PubMedGoogle Scholar
  312. 312.
    Lapinleimu K, Cantell K, Koskimies O, Saxén L: Association between maternal herpes virus infections and congenital malformations. Lancet 2:1127–1129, 1974.Google Scholar
  313. 313.
    Hakosalo J, Saxén L: Influenza epidemic and congenital defects. Lancet 2:1346–1347, 1971.PubMedGoogle Scholar
  314. 314.
    Griffiths PD, Ronalds CJ, Heath RB: A prospective study of influenza infections during pregnancy. J Epidemiol Community Health 34:124–128, 1980.PubMedGoogle Scholar
  315. 315.
    Deinard AS, Ogburn P: A/NJ/8/76 influenza vaccination program — Effects on maternal health and pregnancy outcome. Am J Obstet Gynecol 140:240–245, 1981.PubMedGoogle Scholar
  316. 316.
    Dumont M: Mumps during pregnancy. Nouv Presse Med 7:4302, 1978.PubMedGoogle Scholar
  317. 317.
    Warkany J: Terathanasia. Teratology 17:187–192, 1978.PubMedGoogle Scholar
  318. 318.
    Friedl G, Rautenburg HW: Häufigkeit und Zeitpunkt der Diagnose von angeborenen Herzfehlern in der Praxis. Dtsch Med Wochenschr 105:954–958, 1980.PubMedGoogle Scholar
  319. 319.
    Warkany J: Congenital malformations. Notes and comments. Chicago, Year Book Medical Publishers, 1971.Google Scholar
  320. 320.
    Sylvia Hay, Coordinator. International Clearinghouse for Birth Defects Monitoring Systems. 4141 20th Street, San Francisco, CA 94114, USA.Google Scholar
  321. 321.
    Michel Lechat, Project Leader. European Economic Community. Concerted Action Project Registration of Congenital Anomalies and Twins. Ecole de Santé Publique. Clos Chapelleaux-Champs 30, B-1200 Brussels, Belgium.Google Scholar
  322. 322.
    David Cook, Head. Cardiology Data Centre. The Hospital for Sick Children. 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.Google Scholar
  323. 323.
    Shepard TH: Counseling pregnant women exposed to potentially harmful agents during pregnancy. Clin Obstet Gynecol 26:478–483, 1983.PubMedGoogle Scholar
  324. 324.
    Freeman MM, Finkel MJ: Drug and other hazards to the fetus and newborn. In: Drug and chemical risks to the fetus and newborn, Schwarz RH, Yaffe SJ (eds), New York, Alan R. Liss, Inc., 1980, p 67–72.Google Scholar
  325. 325.
    Dennis NR, Warren J: Risks to the offspring of patients with some common congenital heart defects. J Med Genet 18:8–16, 1981.PubMedGoogle Scholar
  326. 326.
    Wicks JD, Levine MD, Mettler FA: Intrauterine sonography of thoracic ectopia cordis. Am J Roentgenol 137:619–621, 1981.Google Scholar
  327. 327.
    Allan LD, Tynan M, Campbell S, Anderson RH: Identification of congenital cardiac malformations by echocardiography in mid-trimester fetus. Br Heart J 46:358–362, 1981.PubMedGoogle Scholar
  328. 328.
    Crawford CS: Antenatal diagnosis of fetal cardiac abnormalities. Ann Clin Lab Sci 12:99–105, 1982.PubMedGoogle Scholar
  329. 329.
    Kleinman CS, Donnerstein RL, Devore GR, Jaffe CC, Lynch DC, Berkowitz RL, Talner NS, Hobbins JC: Fetal echocardiography for evaluation of in utero congestive heart failure: A technique for study of nonimmune fetal hydrops. N Engl J Med 306:568–574, 1982.PubMedGoogle Scholar
  330. 330.
    Kleinman CS, Hobbins JC, Jaffe CC, Lynch DC, Talner NS: Echocardiographic studies of the human fetus — Prenatal diagnosis of congenital heart disease and cardiac dysrythmias. Pediatrics 65:1059–1067, 1980.PubMedGoogle Scholar
  331. 331.
    Rikitake N, Takechi T, Suzuki K, Matsunaga S, Yoshioka F, Kato H: Fetal echocardiography: Structural evaluation of the fetal heart and prenatal diagnosis of congenital heart disease. J Cardiogr 11:1319–1327, 1981.PubMedGoogle Scholar
  332. 332.
    Campbell S, Pearce JM: Ultrasound visualization of congenital malformations. Br Med Bull 39:322–331, 1983.PubMedGoogle Scholar
  333. 333.
    Hill LM, Breckle R, Gehrking WC: The prenatal detection of congenital malformations by ultrasonography. Mayo Clin Proc 58:805–826, 1983.PubMedGoogle Scholar
  334. 334.
    Allan LD, Little D, Campbell S, Whitehead MI: Fetal ascites associated with congenital heart disease. Br J Obstet Gynecol 88:453–455, 1981.Google Scholar
  335. 335.
    Henrion R, Aubry JP: Fetal cardiac abnormality and real time ultrasound study a case of Ivemark syndrome. In: Contributions to gynecology and obstetrics. Real time ultrasound in perinatal medicine, Sixth Volume, Chef R (ed), Basel, S. Karger, 1979, p 119–122.Google Scholar
  336. 336.
    Devore GR, Donnerstein RL, Kleinman CS, Platt LD, Hobbins JC: Fetal echocardiography. I. Normal anatomy as determined by real-time directed M-mode ultrasound. Am J Obstet Gynecol 144:249–260, 1982.PubMedGoogle Scholar
  337. 337.
    Devore GR, Donnerstein RL, Kleinman CS, Platt LD, Hobbins JC: Fetal echocardiography. II. The diagnosis and significance of a pericardial effusion in the fetus using real-time directed M-mode ultrasound. Am J Obstet Gynecol 144:693–700, 1982.PubMedGoogle Scholar
  338. 338.
    Lange LW, Sahn DJ, Allen HD, Goldberg SJ, Anderson C, Giles H: Qualitative real-time cross-sectional echocardiographic imaging of the human fetus during the 2nd half of pregnancy. Circulation 62:799–806, 1980.PubMedGoogle Scholar
  339. 339.
    Yamaguchi DT, Lee FYL: Ultrasonic evaluation of the fetal heart — Report of experience and anatomic correlation. Am J Obstet Gynecol 134:422–430, 1979.PubMedGoogle Scholar
  340. 340.
    Karp LE: Genetic drift: Fetal surgery. Am J Med Genet 13:357–358, 1982.PubMedGoogle Scholar
  341. 341.
    Kalter H, Warkany J: Congenital malformations: Etiologic factors and their role in prevention (1st part). N Engl J Med 308:424–430, 1983.PubMedGoogle Scholar
  342. 342.
    Kalter H, Warkany J: Congenital malformations: Etiologic factors and their role in prevention (2nd part). N Engl J Med 308:491–497, 1983.PubMedGoogle Scholar
  343. 343.
    Wine LM: Assessing risk in legal proceedings — How to deal with scientific uncertainty in toxic substances risk assessments. In: Human and environmental risks of chlorinated dioxins and related compounds, Tucker RE, Young AL, Gray AP (eds), Env Sci Res, Vol 26, New York, Plenum Publishing Corp., 1983, p 623–627.Google Scholar
  344. 344.
    Goerttler K: Entwicklungsgeschichte des Herzens. In: Das Herz des Menschen, Bd I, Bargmann W, Doerr W (eds), Stuttgart, G. Thieme Verlag, 1963, p 21–87.Google Scholar
  345. 345.
    Chuaqui BJ, Bersch W: The periods of determination of cardiac malformations. Virchows Arch (Pathol Anat) 356:95–110, 1972.Google Scholar
  346. 346.
    Pexieder T, Janecek P: Organogenesis of the human embryonic and early fetal heart as studied by microdissection and SEM. In: Congenital heart disease: Causes and processes, Takao A, Nora J (eds), Mount Kisco, NY, Futura Publishing Co., 1984, p 401–422.Google Scholar
  347. 347.
    Krediet P, Klein HW: Synopsis of normal cardiac development. In: Mechanisms of cardiac morphogenesis and teratogenesis, Pexieder T (ed), New York, Raven Press, 1981, p 7–16.Google Scholar
  348. 348.
    Pexieder T: Cellular abnormalities leading to congenital heart disease. In: Paediatric cardiology 4, Godman MJ (ed), Edinburgh, Churchill Livingstone, 1981, p 24–32.Google Scholar
  349. 349.
    Pexieder T (ed): Mechanisms of cardiac morphogenesis and teratogenesis, New York, Raven Press, 1981.Google Scholar
  350. 350.
    Patterson DF, Pyle RL, VanMierop LHS, Melbin J, Olson M: Hereditary defects of the conotruncal septum in Keeshond dogs. Am J Cardiol 40:936–950, 1977.PubMedGoogle Scholar
  351. 351.
    Pexieder T, Patterson DF: Early pathogenesis of conotruncal malformations in the Keeshond dog. In: Congenital heart disease: Causes and processes, Takao A, Nora J (eds), Mount Kisco, NY, Futura Publishing Co., 1984, p 423–438.Google Scholar
  352. 352.
    Rychter Z, Lemez L: Development of hereditary ventricular septal defects in Siller’s strain of chick embryos. Birth Defects 14:377–386, 1978.PubMedGoogle Scholar
  353. 353.
    Van der Linde-Sipman JS, Wensing CJG: The left hypoplastic heart syndrome in the minipig. Birth Defects 14:295–314, 1978.PubMedGoogle Scholar
  354. 354.
    Layton WM Jr: Heart malformations in mice homozygous for a gene causing situs inversus. Birth Defects 14:277–293, 1978.PubMedGoogle Scholar
  355. 355.
    Layton WM Jr, Manasek FJ: Cardiac looping in early iv/iv mouse embryos. In: Etiology and morphogenesis of congenital heart disease, VanPraagh R, Takao A (eds), Mount Kisco, NY, Futura Publishing Co., 1980, p 109–126.Google Scholar
  356. 356.
    Pexieder T: Heart anomalies in fetal mouse trisomy. Birth Defects 14:387–390, 1978.PubMedGoogle Scholar
  357. 357.
    Pexieder T, Miyabara S, Gropp A: Congenital heart disease in experimental (fetal) mouse trisomies: Incidence. In: Mechanisms of cardiac morphogenesis and teratogenesis, Pexieder T (ed), New York, Raven Press, 1981, p 389–399.Google Scholar
  358. 358.
    Pexieder T: Cellular mechanisms underlying the normal and abnormal development of the heart. In: Etiology and morphogenesis of congenital heart disease, VanPraagh R, Takao A (eds), Mount Kisco, NY, Futura Publishing Co., 1980, p 127–153.Google Scholar
  359. 359.
    Patterson DF: Canine congenital heart disease: Epidemiology and etiological hypotheses. J Small Anim Pract 12:263–287, 1971.PubMedGoogle Scholar
  360. 360.
    Patterson DF: Lesion-specific genetic factors in canine congenital heart disease: Patent ductus arteriosus in poodles, defects of the conotruncal septum in the Keeshond. Birth Defects 14:315–347, 1978.PubMedGoogle Scholar
  361. 361.
    Patterson DF: Genetic aspects of cardiovascular development in dogs. In: Etiology and morphogenesis of congenital heart disease, VanPraagh R, Takao A (eds), Mount Kisco, NY, Futura Publishing Co., 1980, p 1–19.Google Scholar
  362. 362.
    Patterson DF, Haskins ME, Jezyk PF: Models of human genetic disease in domestic animals. In: Advances in human genetics, Volume 12, Harris H, Hirschhorn K (eds), New York, Plenum Publishing Corp., 1982, p 263–340.Google Scholar
  363. 363.
    Patterson DF, Pyle RL, Buchanan JW: Hereditary cardiovascular malformations of the dog. Birth Defects 15:160–174, 1979.Google Scholar
  364. 364.
    Nebert DW: Birth defects and the potential role of genetic differences in drug metabolism. Birth Defects 17:51–70, 1981.PubMedGoogle Scholar
  365. 365.
    Pexieder T: Cell death in the morphogenesis and teratogenesis of the heart. Adv Anat Embryol Cell Biol 51:1–100, 1975.Google Scholar
  366. 366.
    Zierler S, Rothman K.J.: Congenital heart disease in relation to maternal use of Benedectin and other drugs. N. Engl. J. lud. 313:347–352, 1985.Google Scholar

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© Martinus Nijhoff Publishing, Boston 1987

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  • Tomas Pexieder

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