Summary
Recent information on factors affecting metastatic spread of cancer in humans acquired from study of patients treated with peritoneovenous shunts for intractable malignant ascites is reviewed. The evidence indicates that human tumors are heterogeneous in metastatic behavior, that this depends on intrinsic properties of the tumor cells, and that metastasis-competent cells can only colonize sites that are permissive to their presence and growth. The clinical indications for treating patients with peritoneovenous shunts and its complications are discussed, and its value in palliation as well as the absence of significant metastatic sequelae are stressed. The value of the procedure is that it significantly helps terminal patients who otherwise would have a poor quality of life, and it has the by-product of allowing, without distress or hazard, investigation of factors affecting the metastasis of tumors in humans. Already, it has provided direct validation of the applicability of several important observations in animal experiments to the behavior of human metastatic neoplasms.
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References
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© 1986 Martinus Nijhoff Publishing, Boston
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Tarin, D. (1986). Clinicopathologic Studies on Mechanisms of Metastasis in Man and Other Vertebrates. In: Mastromarino, A.J. (eds) Biology and Treatment of Colorectal Cancer Metastasis. Developments in Oncology, vol 42. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2301-3_4
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DOI: https://doi.org/10.1007/978-1-4613-2301-3_4
Publisher Name: Springer, Boston, MA
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