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Biochemistry and Molecular Genetics of Cancer Metastasis pp 101–114Cite as

Cytochemical Cell Typing of Metastatic Tumors According to their Cytoskeletal Proteins

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Part of the book series: Developments in Oncology ((DION,volume 41))

Abstract

Conventional staining methods alone are often insufficient to make accurate histodiagnosis of malignant tumors. However, additional information about the cell type and the state of differentiation of tumor cells can be provided by several molecular markers. To be relevant diagnostically, these markers must be conservative, i.e. expressed not only in well differentiated tumors but also in poorly differentiated tumors and in metastases. These criteria are fulfilled by certain components of the cytoskeleton, notably the proteins forming the intermediate-sized filaments (IFs) and the desmosomal plaque proteins.

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Author information

Authors and Affiliations

  1. Institute of Pathology, University of Mainz Medical School, D-6500, Mainz, Germany

    R. Moll & W. W. Franke

  2. Institute of Cell and Tumor Biology, German Cancer Research Center, D-6900, Heidelberg, Federal Republic of Germany

    R. Moll & W. W. Franke

Authors
  1. R. Moll
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  2. W. W. Franke
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Editor information

Editors and Affiliations

  1. I. Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, 1085, Budapest, Hungary

    Karoly Lapis

  2. Laboratory of Pathology National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Lance A. Liotta  & Alan S. Rabson  & 

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© 1986 Martinus Nijhoff Publishing, Boston

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Moll, R., Franke, W.W. (1986). Cytochemical Cell Typing of Metastatic Tumors According to their Cytoskeletal Proteins. In: Lapis, K., Liotta, L.A., Rabson, A.S. (eds) Biochemistry and Molecular Genetics of Cancer Metastasis. Developments in Oncology, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2299-3_9

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  • DOI: https://doi.org/10.1007/978-1-4613-2299-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9416-0

  • Online ISBN: 978-1-4613-2299-3

  • eBook Packages: Springer Book Archive

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