Cytochemical Cell Typing of Metastatic Tumors According to their Cytoskeletal Proteins

  • R. Moll
  • W. W. Franke
Part of the Developments in Oncology book series (DION, volume 41)


Conventional staining methods alone are often insufficient to make accurate histodiagnosis of malignant tumors. However, additional information about the cell type and the state of differentiation of tumor cells can be provided by several molecular markers. To be relevant diagnostically, these markers must be conservative, i.e. expressed not only in well differentiated tumors but also in poorly differentiated tumors and in metastases. These criteria are fulfilled by certain components of the cytoskeleton, notably the proteins forming the intermediate-sized filaments (IFs) and the desmosomal plaque proteins.


Malignant Pleural Mesothelioma Metastatic Carcinoma Normal Epithelium Laryngeal Squamous Cell Carcinoma Gall Bladder Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1986

Authors and Affiliations

  • R. Moll
    • 1
    • 2
  • W. W. Franke
    • 1
    • 2
  1. 1.Institute of PathologyUniversity of Mainz Medical SchoolMainzGermany
  2. 2.Institute of Cell and Tumor BiologyGerman Cancer Research CenterHeidelbergFederal Republic of Germany

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