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The Recognition and Destruction of Metastatic Cells by Tumoricidal Macrophages

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Biochemistry and Molecular Genetics of Cancer Metastasis

Part of the book series: Developments in Oncology ((DION,volume 41))

Abstract

The most devastating aspect of cancer is the propensity of malignant cells to spread from a primary site to distant organs, where new lesions develop. Indeed, the majority of deaths from cancer are attributed to the continued proliferation of metastases that are resistant to conventional therapeutics. There are several reasons for the failure of treatment for established metastasis. By the time of diagnosis of primary tumors, metastasis may have already occurred, but the lesions are often too small to be detected. Second, the anatomic location of many metastases may limit the effective dose of therapeutic agents that can be delivered to the lesions without being toxic to normal tissues. The third, and most formidable, problem is the heterogeneous nature of malignant neoplasms, which leads to the rapid biological diversification of tumor cells and to the development of resistance to conventional therapy (1,2).

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Author information

Authors and Affiliations

  1. Department of Cell Biology, The University of Texas, M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas, USA

    I. J. Fidler

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  1. I. J. Fidler
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Editor information

Editors and Affiliations

  1. I. Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, 1085, Budapest, Hungary

    Karoly Lapis

  2. Laboratory of Pathology National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Lance A. Liotta  & Alan S. Rabson  & 

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© 1986 Martinus Nijhoff Publishing, Boston

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Fidler, I.J. (1986). The Recognition and Destruction of Metastatic Cells by Tumoricidal Macrophages. In: Lapis, K., Liotta, L.A., Rabson, A.S. (eds) Biochemistry and Molecular Genetics of Cancer Metastasis. Developments in Oncology, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2299-3_16

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  • DOI: https://doi.org/10.1007/978-1-4613-2299-3_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9416-0

  • Online ISBN: 978-1-4613-2299-3

  • eBook Packages: Springer Book Archive

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