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Biochemistry and Molecular Biology Raw117 Large Cell Lymphoma

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Biochemistry and Molecular Genetics of Cancer Metastasis

Part of the book series: Developments in Oncology ((DION,volume 41))

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Abstract

Animal tumor models for studying cellular properties important in metastatic tumor spread have been established by sequential selection in vivo or in vitro to obtain variant cells with enhanced metastatic and organ colonization behaviors (1–4). Using the murine large cell lymphoma line RAW117 we have developed a metastatic system that shows preferential organ colonization (5–7). This tumor system was derived from parental RAW117-P large cell lymphoma or lymphosarcoma, which is an Abelson murine leukemia virus (Ab-MLV) transformed cell line of recent origin that colonizes lungs, liver, spleen and lymph nodes at low frequencies in BALB/c mice (8). Metastatic variant sublines were sequentially selected from RAW117-P for their abilities to colonize liver, and after ten such in vivo selections, subline RAW117-H10 was established (5). The RAW117-H10 variant subline is highly metastatic and rapidly kills its host. For example, H10 cells form more than 200 times as many gross surface liver tumor nodules after intravenous or subcutaneous injection than does the parental RAW117-P line (5, 6, 9, 10).

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Author information

Authors and Affiliations

  1. Department of Tumor Biology, The University of Texas — M.D. Anderson Hospital and Tumor Institute, Houston, Texas, 77030, USA

    G. L. Nicolson, T. Irimura, C. L. Reading & R. La Biche

  2. Department of Biophysics, The Weizmann Institute of Science, Rehovot, 76100, Israel

    V. Rotter & D. Wolf

  3. Department of Clinical Immunology and Biological Therapy, The University of Texas — M.D. Anderson Hospital and Tumor Institute, Houston, Texas, 77030, USA

    M. Blick

  4. Department of Medicine, Baylor College of Medicine, Houston, Texas, 77030, USA

    M. Frazier

Authors
  1. G. L. Nicolson
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  2. V. Rotter
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  3. D. Wolf
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  4. T. Irimura
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  5. C. L. Reading
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  6. M. Blick
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  7. R. La Biche
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  8. M. Frazier
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Editor information

Editors and Affiliations

  1. I. Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, 1085, Budapest, Hungary

    Karoly Lapis

  2. Laboratory of Pathology National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Lance A. Liotta  & Alan S. Rabson  & 

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© 1986 Martinus Nijhoff Publishing, Boston

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Nicolson, G.L. et al. (1986). Biochemistry and Molecular Biology Raw117 Large Cell Lymphoma. In: Lapis, K., Liotta, L.A., Rabson, A.S. (eds) Biochemistry and Molecular Genetics of Cancer Metastasis. Developments in Oncology, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2299-3_10

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  • DOI: https://doi.org/10.1007/978-1-4613-2299-3_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9416-0

  • Online ISBN: 978-1-4613-2299-3

  • eBook Packages: Springer Book Archive

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