Abstract
The data presented in this study are in favour of the clinical interest of RBC polyamine determination in the monitoring of patients harboring anaplastic gliomas: 1) In the case of tumor progression, RBC spermidine levels, and spermine levels to some extent, seem closely associated with the modification of TDM images. 2) In the case of clinical deterioration, an increase of RBC spermidine levels significantly higher than those of controls was observed, but constantly correlated to those of erythrocyte spermine concentrations. 3) All patients with a Karnofsky (K) index ≤S5O related to tumor progression show straight regression lines with slopes superior to 1.80 (in this study). 4) In the presence of a patient with normal values of RBC polyamine levels, clinical and/or TDM arguments of tumor progression have to be reconsidered. If RBC polyamine levels appear in neurooncology as a rather reliable index of tumor cell proliferation, the treatment strategy of patients harboring anaplastic gliomas could be more biologically adapted, according to the importance in each patient of the intracranial hyperplastic level at the time of therapy.
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References
Moulinoux JPh, Quemener V, Le Calve M, Chatel M, Darcel F: Polyamines in human brain tumors. A correlative study between tumor, cerebrospinal fluid and red blood cell free polyamine levels. J Neuro-oncology (JNO) 2: 153–158, 1984
Marton LJ, Heby O, Wilson CB: Increased polyamine con-centrations in the cerebrospinal fluid of patients with brain tumors. Int F Cancer 14: 731–735, 1974
Marton LJ, Edwards MS, Levin VA, Lubich WP, Wilson CB: Predictive value of cerebrospinal fluid polyamines in medulloblastoma. Cancer Res 39: 993–997, 1979
Marton LJ, Edwards MS, Levin VA, Lubich WP, Wilson CB: CSF polyamines: A new and important means of monitoring patients with medulloblastoma. Cancer 47: 757–760, 1981
Pierangelli E, Levin VA, Seidenfeld J, Marton JL: Putrescine diffusion in cat brain and capillary permeability in rat brain: Relation to CSF putrescine levels in brain tumor patients. Eur J Cancer 17: 143–147, 1981
Scalabrino G, Modena D, Ferioli ME, Puerari M, Lucarelli G: Degrees of malignancy in human primary CNS tumors: ODC levels as better indicators than S-adenosylmethionine decarboxylase levels. JNCI 68: 751–754. 1982
Cohen LF, Lundgren DW, Farre UPM: Distribution of sper-midine and spermine in blood from cystic fibrosis patients and control subjects. Blood 48: 409–475, 1976
Moulinoux JPh, Le Calve M, Quemener V, Quash G: In vitro studies on the entry of polyamines into normal red blood cells. Biochimie 66: 385–393, 1984
Moulinoux JPh, Quemener V, Larzull JJ, Le Calve M, Roch AM, Toujas L, Quash GA: Red blood cell polyamines in mice bearing the lewis lung carcinoma (3 LL) and in patients with bronchopulmonary cancers. Int J Cancer 34: 277–281, 1984
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© 1986 Martinas Nijhoff Publishers, Boston
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Moulinoux, J.P., Quemener, V., Hercouet, H., Darcel, F., Chatel, M. (1986). Red blood cell polyamines in malignant glioma patients. Spermidine and spermine blood levels and tumour evolution. In: Walker, M.D., Thomas, D.G.T. (eds) Biology of Brain Tumour. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2297-9_9
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DOI: https://doi.org/10.1007/978-1-4613-2297-9_9
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