Cyclophosphamide, Adriamycin, vincristine, and dexamethasone in the treatment of bulky central nervous system lymphoma

  • David J. Stewart
  • Neville Russell
  • Jean Dennery
  • Michael T. Richard
  • Edward Atack
  • Libni Eapen
  • André Girard
  • Jean A. Maroun
  • Zvonimir Grahovac
  • Garry Bélanger

Abstract

Six patients with bulky central nervous system lymphomas (5 primary and 1 metastatic) were treated with a combination of cyclophosphamide, Adriamycin, vincristine, and dexamethasone IV prior to receiving cranial irradiation. There was one early death from massive hemorrhage from peptic ulcer disease. The other 5 patients all had rapid marked shrinkage of tumor, but 3 developed progression or appearance of meningeal disease. In light of these results and of the generally poor prognosis of brain lymphomas managed by radiotherapy alone, we plan further studies combining intensive systemic chemotherapy with intensive intrathecal chemotherapy and cranial irradiation.

Keywords

Lymphoma Hydrocortisone Dexamethasone Doxorubicin Methotrexate 

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Copyright information

© Martinas Nijhoff Publishers, Boston 1986

Authors and Affiliations

  • David J. Stewart
    • 1
  • Neville Russell
    • 1
  • Jean Dennery
    • 1
  • Michael T. Richard
    • 1
  • Edward Atack
    • 1
  • Libni Eapen
    • 1
  • André Girard
    • 1
  • Jean A. Maroun
    • 1
  • Zvonimir Grahovac
    • 1
  • Garry Bélanger
    • 1
  1. 1.The Ontario Cancer Treatment and Research FoundationOttawa Clinics and the University of OttawaOttawaCanada

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