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Cyclophosphamide, Adriamycin, vincristine, and dexamethasone in the treatment of bulky central nervous system lymphoma

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Biology of Brain Tumour

Abstract

Six patients with bulky central nervous system lymphomas (5 primary and 1 metastatic) were treated with a combination of cyclophosphamide, Adriamycin, vincristine, and dexamethasone IV prior to receiving cranial irradiation. There was one early death from massive hemorrhage from peptic ulcer disease. The other 5 patients all had rapid marked shrinkage of tumor, but 3 developed progression or appearance of meningeal disease. In light of these results and of the generally poor prognosis of brain lymphomas managed by radiotherapy alone, we plan further studies combining intensive systemic chemotherapy with intensive intrathecal chemotherapy and cranial irradiation.

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Author information

Authors and Affiliations

  1. The Ontario Cancer Treatment and Research Foundation, Ottawa Clinics and the University of Ottawa, Ottawa, Ontario, Canada

    David J. Stewart, Neville Russell, Jean Dennery, Michael T. Richard, Edward Atack, Libni Eapen, André Girard, Jean A. Maroun, Zvonimir Grahovac & Garry Bélanger

Authors
  1. David J. Stewart
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  2. Neville Russell
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  3. Jean Dennery
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  4. Michael T. Richard
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  5. Edward Atack
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  6. Libni Eapen
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  7. André Girard
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  8. Jean A. Maroun
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  9. Zvonimir Grahovac
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  10. Garry Bélanger
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Editor information

Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Michael D. Walker M.D

  2. Institute of Neurology, University of London, London, England

    David G. T. Thomas MRCP, FRCSE

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© 1986 Martinas Nijhoff Publishers, Boston

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Stewart, D.J. et al. (1986). Cyclophosphamide, Adriamycin, vincristine, and dexamethasone in the treatment of bulky central nervous system lymphoma. In: Walker, M.D., Thomas, D.G.T. (eds) Biology of Brain Tumour. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2297-9_59

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  • DOI: https://doi.org/10.1007/978-1-4613-2297-9_59

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9415-3

  • Online ISBN: 978-1-4613-2297-9

  • eBook Packages: Springer Book Archive

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