Modern neuropathological investigative techniques of brain tumours

Abstract

The aim of the neuropathologist is to examine brain tumours at three levels of analysis: tissues, cells and molecules. It is the second and third aspects of study which have provided the most rewarding developments. The scope of investigations of cerebral neoplasms has widened dramatically during the last two decades. The new investigative techniques of electron microscopy, enzyme histochemistry, immunocytochemistry, tissue culture and cytogenetics not only facilitate diagnosis, but also contribute to the understanding of the development and cell biology of cerebral neoplasia. These investigations bridge the gap which exists between morphology on one hand, and biochemistry, physiology, immunology and cell biology on the other. The application of these techniques enables evolution from a morphological basis to a biological approach in the study of brain tumours.