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Limitations and Potentials of In Vitro Sensitivity Testing of Human Small Cell Carcinoma of the Lung

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Lung Cancer: Basic and Clinical Aspects

Part of the book series: Cancer Treatment and Research ((CTAR,volume 28))

Abstract

The clonogenic assay has been proposed both as a tool for individually guided chemotherapy and as a preclinical drug evaluation system. Because tumor cells are heterogeneous it is unlikely that a test where only a minor fraction of the cells is tested can predict the sensitivity of all tumor cells in the patient. The pronounced negative accuracy reported can be explained on the basis of the patient populations being studied. The technical limitations of the test are presented, and it is concluded that with the present status of the test, it is only suited as a preclinical test system.

It is suggested that in vitro sensitivity testing of drugs in a panel of cell lines established from patients with small cell carcinoma of the lung might help to identify drugs that could alter the clinical course of the disease.

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Authors
  1. Henrik Roed
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  2. Lars L. Vindeløv
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  3. Mogens Spang-Thomsen
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  4. Svend Aa. Engelholm
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Editor information

Editors and Affiliations

  1. Department of Oncology II, Finsen Institute, 49 Strandsoulevarden, DK - 2100, Copenhagen, Denmark

    Heine H. Hansen

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© 1986 Martinus Nijhoff Publishers, Boston

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Roed, H., Vindeløv, L.L., Spang-Thomsen, M., Engelholm, S.A. (1986). Limitations and Potentials of In Vitro Sensitivity Testing of Human Small Cell Carcinoma of the Lung. In: Hansen, H.H. (eds) Lung Cancer: Basic and Clinical Aspects. Cancer Treatment and Research, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2295-5_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2295-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9414-6

  • Online ISBN: 978-1-4613-2295-5

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