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Therapy of Lung Cancer-Any progress? An Overview of the Last Decade

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Lung Cancer: Basic and Clinical Aspects

Part of the book series: Cancer Treatment and Research ((CTAR,volume 28))

Abstract

Parallel with a continuing increase in the incidence of lung cancer in most countries a rapid increase in the number of articles on this disease has occurred during the last decade. The majority of these articles has focused on the various modes of therapy and many of them have expressed various degrees of therapeutic optimism. This optimism is mainly based on the improved results obtained by intensive cytostatic treatment of small cell lung cancer. This subgroup of bronchogenic carcinoma has during the same period been established as a specific disease entity with the features of a systemic disease. However, more recently considerable therapeutic optimism has also been expressed for the other major histologic cell types of lung cancer [1]. It is the purpose of this article critical to summarize the existing literature from 1978–1985 in order to evaluate if there is a reasonable basis for this optimism and also to see whether the existing literature will give us guidelines as to the direction in which to move clinically in the future treatment of lung cancer.

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References

  1. Soulier JP, Klastersky J: Progress in chemotherapy of non-small cell lung cancer. Eur J Cancer Clin Oncol 20:1329–1333, 1984.

    Article  Google Scholar 

  2. Hansen HH, Rørth M: In: Cancer Chemotherapy, Pinedo HM (ed.) 1:267–291, 1979.

    Google Scholar 

  3. Hansen HH, Rørth M: In: Cancer Chemotherapy, Pinedo HM (ed.) 2:267–283, 1980.

    Google Scholar 

  4. Hansen HH, Rørth M: In: Cancer Chemotherapy, Pinedo HM (ed.) 3:279–296, 1981.

    Google Scholar 

  5. Hansen HH, Rørth M: In: Cancer Chemotherapy, Pinedo HM (ed.) 4:249–271, 1982.

    Google Scholar 

  6. Hansen HH, Rørth M: In: Cancer Chemotherapy, Pinedo HM (ed.) 5:307–325, 1983.

    Google Scholar 

  7. Hansen HH, Rørth M: In: Cancer Chemotherapy, Pinedo HM, Chabner BA (eds.) 6:299–321, 1984.

    Google Scholar 

  8. Rudnick SA, Feinstein AR: An analysis of the reporting of the results in Lung Cancer Trials J Natl Cancer Inst 64:1337–1343, 1980.

    PubMed  CAS  Google Scholar 

  9. Aisner J, Alberto P, Bitran J, Comis R, Daniels J, Hansen H, Ikegoritzi H, Smyth J: Role of chemotherapy in small cell lung cancer. A concensus report of the IASLC Lung Cancer Workshop. Cancer Treat Rep 67:37–44, 1983.

    PubMed  CAS  Google Scholar 

  10. Roswitt B, Patno ME, Rapp R, Veinbergs A, Feder B, Stuhlbarg H, Reid CB: The survival of patients with inoperable lung cancer: A large-scale randomized study of radiation therapy versus placebo. Radiology 90:688–697, 1968.

    Google Scholar 

  11. Kokron O, Michske M, Titscher R, Wrba H: Ifosfamid versus Ifosfamid + CCNU in der Behandlung des inoperablen Kleinzelligen Bronchus Karzinoms. Eine Klinische Studie. Onkologie 5:56–49, 1982.

    Article  PubMed  CAS  Google Scholar 

  12. Lundar J: Small-celled anaplastic lung carcinoma. Scand J Rep Dis 72:139–140, 1980.

    Google Scholar 

  13. Lokich JJ, Skarin AT: Undifferentiated small-cell (oat-cell) carcinoma of the lung. Prospects for long-term survival. NY State J Med 1263–1267, 1977.

    Google Scholar 

  14. Maurer LH, Tulloh M, Weiss RB, Blom J, Leone L, Glidewell O, Pajak TF: A randomized combined modality in small cell carcinoma of the lung. Comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy effects of maintenance chemotherapy and prophylactic whole brain irradiation. Cancer 45 [30–39, 1980.

    Article  PubMed  CAS  Google Scholar 

  15. Østerlind K, Hansen HH: Unpublished data.

    Google Scholar 

  16. Ginsberg SJ, Comis RL, Gottlieb AJ, King GB, Goldberg J, Zamkoff K, Elbadawi A, Meyer JA: Long-term survivorship in small-cell anaplastic lung carcinoma. Cancer Treat Rep 63:1347–1349, 1979.

    PubMed  CAS  Google Scholar 

  17. Morstyn G, Ihde DC, Lichter AS, Bunn PA, Carney DN, Glatstein E, Minna JD: Small cell lung cancer 1973–1983: Early progress and recent obstacles. Int J Radiat Oncol Biol Phys 10:515–539, 1984.

    Article  PubMed  CAS  Google Scholar 

  18. Livingston RB, Stephens RL, Bonnet JD, Grozea PN, Lehane DE: Long-term survival and toxicity in small cell lung cancer. Southwest Oncology Group Study. Am J Med 77:415–417, 1984.

    Article  PubMed  CAS  Google Scholar 

  19. Daniels JR, Chak LY, Sikic BI, Lockbaum P, Kohler M, Carter SK, Reynolds R, Bohnen R, Gandara D, Yu J: Chemotherapy of small-cell carcinoma of lung: A randomized comparison of alternating and sequential combination chemotherapy programs. J Clin One 2:1192–1199, 1984.

    CAS  Google Scholar 

  20. Bleehen NM: Cytotoxic chemotherapy before and after radiotherapy compared with radiotherapy followed by chemotherapy in the treatment of small-cell carcinoma of the bronchus: results up to 36 months. Br J Cancer 48:755–761, 1983.

    Article  Google Scholar 

  21. Feld R, Evans WK, DeBoer G, Quirt IC, Shepherd FA, Yeah JL, Pringle JF, Payne DG, Herman JG, Chamberlain D, Brown TC, Baker MA, Myers R, Blackstein ME, Pritchard KI: Combined modality induction therapy without maintenance chemotherapy for small cell carcinoma of the lung. J Clin Oncol 2:294–304, 1984.

    PubMed  CAS  Google Scholar 

  22. Souhami RL, Geddes DM, SPiro SG, Harper PG, Tobias, JS, Mantell BS, Fearon F, Bradbury I: Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: a controlled trial. Br Med J 288:1643–1646, 1984.

    Article  CAS  Google Scholar 

  23. Pedersen-Bjergaard J, Østerlind K, Hansen M, Philip P, Pedersen AG, Hansen HH: Secondary malignancies following intensive chemotherapy of small cell carcinoma of the lung. Blood in press 1986.

    Google Scholar 

  24. Chak LY, Sikic BI, Tucker MA: Increased incidence of acute non lymphocytic leukemia following therapy in patients with small cell carcinoma of the lung. J Clin Oncol 2:385–390, 1984.

    PubMed  Google Scholar 

  25. Vindeløv, LL, Hansen HH, Christensen IJ, Spang-Thomsen M, Hirsch FR: Clonal heterogeneity of small-cell anaplastic carcinoma of the lung demonstrated by flow-cytometric DNA analysis. Cancer Res 40:4295–4300, 1980.

    PubMed  Google Scholar 

  26. Osterlind K, Hansen HH, Dombernowsky P, Rørth M, Sørenson S, Vindeløv L: Combination chemotherapy of small cell lung cancer (SCC) based on in vivo cell cycle analysis. Results of a randomized trial of 254 patients. Proc Am Ass Cancer Res 23:154, 1982.

    Google Scholar 

  27. Postmus P, Sleijfer DTH, Mulder NH: High-dose chemotherapy for small cell lung cancer: In: Lung Cancer. Hansen HH (ed.). In press, 1985.

    Google Scholar 

  28. Elliott JA, Østerlind K, Hansen HH: Cyclic alternating non-cross resistant chemotherapy in the management of small cell anaplastic carcinoma of the lung. Cancer Treat Rev 11:103–113, 1984.

    Article  PubMed  CAS  Google Scholar 

  29. Goldie JH, Coldman AJ, Gudanskas GA: Radionale for the use of alternating non-cross resistant chemotherapy. Cancer Treat Rep 66:439–449, 1982.

    PubMed  CAS  Google Scholar 

  30. Østerlind K, Sörenson S, Hansen HH, Dombernowsky P, Hirsch FR, Hansen M, Rorth M: Treatment of advanced small cell carcinoma of the lung: Continuous versus alternating combination chemotherapy. Cancer Res 43:6085–6089, 1983.

    PubMed  Google Scholar 

  31. Gullen MH, Morgan DAL, Richards MA, Robinson M, Ward M, Cox M: Maintenance chemotherapy for small cell lung cancer — A randomized trial. Abstracts. 2nd Europ Conf Clin One and Cancer Nursing, p. 118, 1983.

    Google Scholar 

  32. Woods RJ, Levi JA: Chemotherapy for small cell lung cancer (SCLC). A randomized study of maintenance therapy with cyclophosphamide, adriamycin and vincristin (CAV) after remission induction with cis-platinum (Cis-DDP), VP-16–213 and radiotherapy. Abstracts. 2nd Europ Conf Clin One and Cancer Nursing, p 119, 1983.

    Google Scholar 

  33. Poplin EA, Aisner J, Van Echo DA, Whitacre M, Wiernik PH: CCNU, Vincristine, Methotrexate and Procarbazine treatment of relapsed small cell lung carcinoma. Cancer Treat Rep 66:1557–1559, 1982.

    PubMed  CAS  Google Scholar 

  34. Daugaard G, Hansen HH, Rørth M: Phase II study of vindesine, cisplatin, and hexame-thylmelamine (VCH) in small cell carcinoma of the lung. Cancer Treat Rep 68:1179–1181, 1984.

    PubMed  CAS  Google Scholar 

  35. Joss RA, Brunner KW, Goldhirsch A: Mitomycin, Hexamethylmelamine and Vindesine as second-line treatment for small cell cancer of the lung. Cancer Treat Rep 66:1873–1874, 1982.

    PubMed  CAS  Google Scholar 

  36. Chahinian AP, Green G, Holland JF: Mitomycin-C, etoposide, cisplatin and hexamethylmelamine (MEPH) as a second-line regimen in lung cancer. Am J Clin Oncol (CCT) 7:419–423, 1984.

    Article  CAS  Google Scholar 

  37. Evans WK, Feld R, Osoba D, Shepherd FA, Dill J, Deboer G: VP-16 alone and in combination with cisplatin in previously treated patients with small cell lung cancer. Cancer 53:1461–1466, 1984.

    Article  PubMed  CAS  Google Scholar 

  38. Joss RA, Obrecht JP, Jungi WF, Alberto P, Sauter C, Cavalli F: Phase II study of vindesine and hexamethylmelamine in patients with relapsing small cell carcinoma of the lung. Cancer Chemother Pharmacol 13:148–149, 1984.

    Article  PubMed  CAS  Google Scholar 

  39. Niederle N, Schütte J, Schmidt CG, Seeber S: Treatment of recurrent small cell lung carcinoma with vindesine and cisplatin. Cancer Treat Rep 68:791–792, 1984.

    PubMed  CAS  Google Scholar 

  40. Batist G, Ihde DC, Cowa, K, Veach S, Gilliom M, Bunn PA: Phase II trial of cisplatin and VP-16 in previously treated small cell lung cancer (SCLC). Proc Amer Ass Cancer Res Abstracts: 694, 1984.

    Google Scholar 

  41. Einhorn LH, Williams SD, Loehrer PJ: Platinum (P) + VP-16 chemotherapy for refractory small cell lung cancer (RSCLC). Proc Amer Ass Cancer Res Abstracts: 689, 1984.

    Google Scholar 

  42. Pedersen AG, Hansen HH: Etoposide (VP-16) in the treatment of lung cancer. Cancer Treat Rev 10:245–264, 1983.

    Article  PubMed  CAS  Google Scholar 

  43. Bork E, Hansen SW, Pedersen AG, Dombernowsky P, Hansen H, Hansen HH: Phase II study of VM-26 (Teniposide) in untreated patients with small cell lung cancer (SCC). Cancer Chemother Pharmacol Suppl 14: p 8, 1984.

    Google Scholar 

  44. Smith IE, Harland SJ, Robinson BA, Evans BD, Goodhart LC, Caluert AM, Jarnold J, Glees JP, Baker J, Ford HT: Carboplatin: A very active non cis-platinum analog in the treatment of small cell lung cancer. Cancer Treat Rep 69:43–46, 1985.

    PubMed  CAS  Google Scholar 

  45. Madajewicz H, Takita PJ, Creaven PJ, Bareniewski H, Regal AM, Cushman K: Phase II study of iproplatin (IPP) in small cell carcinoma of the lung (SCCL). Proc Am Soc Clin Oncol:876, 1984.

    Google Scholar 

  46. Atassi G: Do we need new chemosensitive experimental models? Eur J Cancer Clin Oncol 20:1217–1220, 1984.

    Article  PubMed  CAS  Google Scholar 

  47. Roed H, Vindelov LL, Spang-Thomsen M, Engelholm SA: Limitations and potentials of in vitro sensitivity testing of human small cell carcinoma of the lung. In: Lung Cancer III. Hansen HH (ed.), in press.

    Google Scholar 

  48. Byhardt RW, Cok JD: Is chest radiotherapy necessary in any or all patients with small cell lung cancer? Yes. Cancer Treat Rep 67:209–216, 1983.

    CAS  Google Scholar 

  49. Cohen MH: Is thoracic irradiation necessary for patients with limited-stage small cell lung cancer. Cancer Treat Rep 67:217–000, 1983.

    PubMed  CAS  Google Scholar 

  50. Byhardt RW, Cox JD, Wilson JF et al.: Total body irradiation vs chemotherapy as a systemic adjuvant for small cell carcinoma of the lung. Int J Radiat Oncol biol Phys 5:2043–2048, 1979.

    Article  PubMed  CAS  Google Scholar 

  51. Dillmann RP, Seagreren SL, Taetle R: Failure of low dose, total body irradiation to augment combination chemotherapy in extensive stage small cell carcinoma of the lung. J Clin Oncol 1:242–246, 1983.

    Google Scholar 

  52. Østerlind K, Hansen HH, Rørth M, Hansen M, Dombernowsky P: Treatment policy of surgery in small cell carcinoma of the lung. A retrospective analysis of a group of 874 consecutive patients. Thorax. In press, 1985.

    Google Scholar 

  53. Zacharski LR, Henderson WG, Rickles: Effect of warfarin in small cell carcinoma of the lung. J Amer Med Ass 245:831–835, 1981.

    Article  CAS  Google Scholar 

  54. Aisner J, Hansen HH: Commentary: Current status of chemotherapy for non-small cell lung cancer. Cancer Treat Rep 65:979–986, 1981.

    PubMed  CAS  Google Scholar 

  55. Lad TE, McQuire WP: Chemotherapy for non-small cell lung cancer. In: Lung Cancer. Aisner J (ed.). Churchill Livingstone, p 155–183, 1985.

    Google Scholar 

  56. Chahinian AP, Pajak TF, Holland JF, Norton L, Ambinder RM, Mandel EM: Diffuse malignant mesothelioma. Ann Intern Med 96:746–755, 1982.

    PubMed  CAS  Google Scholar 

  57. Antman K, Blum RH, Greenberger JS, Flowerdew G, Skarin AT, Canellos GP: Multimo-dality therapy for malignant mesothelioma based on a study of natural history. Amer J Med 68:356–362, 1980.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Heine H. Hansen
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  2. Mikael Rørth
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Editors and Affiliations

  1. Department of Oncology II, Finsen Institute, 49 Strandsoulevarden, DK - 2100, Copenhagen, Denmark

    Heine H. Hansen

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© 1986 Martinus Nijhoff Publishers, Boston

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Hansen, H.H., Rørth, M. (1986). Therapy of Lung Cancer-Any progress? An Overview of the Last Decade. In: Hansen, H.H. (eds) Lung Cancer: Basic and Clinical Aspects. Cancer Treatment and Research, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2295-5_14

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  • DOI: https://doi.org/10.1007/978-1-4613-2295-5_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9414-6

  • Online ISBN: 978-1-4613-2295-5

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