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Adenovirus Genetics

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Part of the book series: Developments in Molecular Virology ((DMVI,volume 8))

Abstract

Over the past twelve years or so a large number of adenoviral mutants has been isolated, and many of these have been used to analyse the functions of viral gene products involved in the processes of infection and transformation. Within the past year two extensive reviews on the topic of adenovirus genetics have been published. One of these (1) surveys the physiological consequences of mutations in viral genes in cells infected or transformed by group C adenoviruses (types 2 and 5), while the other (2) deals largely with genetic methodology and the study of genetic interactions. Between them these reviews provide a comprehensive summary of group C adenoviral genetics until late 1983. Although some reiteration of this information is inevitable, my main purpose here is to provide an update on progress made during the past year. Most of this progress has been made in areas relating to adenoviral early genes, and accordingly, much of the discussion in this chapter will be confined to analysis of mutations in these genes. For more detailed discussion of late-function mutants, the reader is referred to the above reviews. Further, the mutants made to investigate transcriptional and other control regions are discussed elsewhere in this volume, and will not be dealt with in this chapter. Recently, considerable progress has been made in the genetic analysis of type 12 (group A) adenovirus, and since this material was not included in these two reviews, it will be dealt with here.

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Williams, J. (1986). Adenovirus Genetics. In: Doerfler, W. (eds) Adenovirus DNA. Developments in Molecular Virology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2293-1_8

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