Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Head and Neck Complications of Bone Marrow Transplantation

  • Chapter
Head and Neck Management of the Cancer Patient

Part of the book series: Developments in Oncology ((DION,volume 36))

Abstract

In the late 1950s, the technique of human marrow transplantation was first applied, and these initial attempts were viewed with enthusiasm as a means to treat blood dyscrasias or marrow failure. However, these early attempts often met with failure; in a study of 203 of the early marrow grafts, only 22 (11%) were unequivocally successful allogeneic transplants [1]. The problems preventing success included graft failure, graft-versus-host disease (GVHD), bleeding and infectious complications resulting from marrow and immunologic ablation, and recurrence of disease [2]. During the 1960s, advances in histocompatability typing, pretransplant conditioning, immunosuppressive therapy, and improved supportive care and infection control laid the groundwork for a resurgence of human marrow grafting. Today, marrow transplantation is considered an effective treatment for severe aplastic anemia, acute leukemias, and immunodeficiency disorders [3–5] (see chapter 8).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bortin MM: A compendium of reported human bone marrow transplants. Transplantation 9:571–587, 1970.

    PubMed  CAS  Google Scholar 

  2. Santos G: History of bone marrow transplantation. Clin Haematol 12:611–639, 1983.

    PubMed  CAS  Google Scholar 

  3. Storb R, Thomas ED, Buckner CD, Apple- baum FR, Clift RA, Deeg HJ, Doney K, Hansen J A, Prentice RL, Sanders J, Stewart P, Sullivan KM, Witherspoon RP: Marrow transplantation for aplastic anemia. Semin Hematol 21:27–35, 1984.

    PubMed  CAS  Google Scholar 

  4. Thomas ED: Marrow transplantation for malignant diseases (Karnofsky Memorial Lecture). J Clin Oncol 1:517–531, 1983.

    PubMed  CAS  Google Scholar 

  5. O’Reilly RJ: Allogeneic bone marrow transplantation: current status and future directions. Blood 62:941–964, 1983.

    PubMed  Google Scholar 

  6. Lockhart PB: Dental management of patients receiving chemotherapy. In: Peterson DE, Sonis ST (eds) Oral complications of cancer chemotherapy. Boston, Martinus Nijhoff, 1983, pp 113–149.

    Google Scholar 

  7. Schubert MM, Sullivan KM, Izutsu KT, Truelove EL: Oral complications of bone- marrow transplantation. In: Peterson DE, Sonis ST (eds) Oral complications of cancer chemotherapy. Boston, Martinus Nijhoff, 1983, pp 93–112.

    Google Scholar 

  8. Peterson DE: Bacterial infections: periodontal and dental disease. In: Peterson DE, Sonis ST (eds) Oral complications of cancer chemotherapy. Boston, Martinus Nijhoff, 1983, pp 79–91.

    Google Scholar 

  9. Peterson DE, Overholser CD, Williams LT. Endodontic therapy in patients receiving myelosuppressive chemotherapy. Proc J Dent Res 61:276, 1982.

    Google Scholar 

  10. Williams LT, O’Dwyer JL: Guidelines for oral hygiene, denture care, and nutrition in patients with oral complications. In: Peterson DE, Sonis ST (eds) Oral complications of cancer chemotherapy. Boston, Martinus Nijhoff, 1983, pp 151–168.

    Google Scholar 

  11. Meadows AT, Evans AE: Effects of chemotherapy on the central nervous system: a study of parenteral methotrexate in long-term survivors of leukemia and lymphoma in childhood. Cancer 37:1079–1085, 1976.

    PubMed  CAS  Google Scholar 

  12. Catane R, Schwade JG, Yarr I: Neurological evaluation in patients with small cell carcinoma treated with prophylactic follow-up cranial irradiation and chemotherapy. Int J Radiat Oncol Biol Phys 7:105–109, 1981.

    PubMed  CAS  Google Scholar 

  13. Rubenstein JJ, Herman MM, Long TF, Wilbur JR: Disseminated necrotizing leukoencephalo- pathy: a complication of treated central nervous system leukemia and lymphoma. Cancer 35: 291–305, 1975.

    Google Scholar 

  14. Price RA, Jamieson PA: The central nervous system in childhood leukemia. II. Subacute leukoencephalopathy. Cancer 35:306–317, 1975.

    PubMed  CAS  Google Scholar 

  15. Chien LT, Aur RJA, Verzosa MS, Coburn TP, Goff JR, Hustu HD, Price RA, Seifert J, Simone JV: Progression of methotrexate- induced leukoencephalopathy in children with leukemia. Med Pediatr Oncol 9:133–141, 1981.

    CAS  Google Scholar 

  16. Buckner CD, Clift RA, Thomas ED, Sanders JE, Hackman R, Stewart PS, Storb R, Sullivan KM: Allogeneic marrow transplantation for patients with acute non-lymphoblastic leukemia in second remission. Leuk Res 6:395–399, 1982.

    PubMed  CAS  Google Scholar 

  17. Kolbinson DA: Early oral changes following bone marrow transplantation. MSD thesis, Department of Oral Medicine, School of Dentistry, University of Washington, 1983.

    Google Scholar 

  18. Winston DJ, Gale RP, Meyer DV, Young LS: Infectious complications of human bone marrow transplantation. Medicine 58:1–31, 1979.

    PubMed  CAS  Google Scholar 

  19. Navari RM, Buckner CD, Clift RA, Storb R, Sanders JE, Stewart P, Sullivan KM, Williams B, Counts GW, Meyers JD, Thomas ED: Prophylaxis of infection in patients with aplastic anemia receiving allogeneic marrow transplants. Am J Med 76:564–572, 1984.

    PubMed  CAS  Google Scholar 

  20. Sonis A, Sonis S: Oral complications of cancer chemotherapy in pediatric patients. J Pedodon- tics 3:122–128, 1979.

    CAS  Google Scholar 

  21. Blozis GG, Robinson JE: Oral tissue changes caused by radiation therapy and their management. Dent Clin North Am 12:643–656, 1968.

    Google Scholar 

  22. Buckner CD, Clift RA, Sanders JE, Meyers JD, Counts GW, Farewell VT, Thomas ED: Protective environment for marrow transplant recipients: a prospective study. Ann Intern Med 89:893–901, 1978.

    PubMed  CAS  Google Scholar 

  23. Meyers JD, Atkinson K: Infection in bone marrow transplantation. Clin Haematol 12:791–811, 1983.

    PubMed  CAS  Google Scholar 

  24. Peterson PK, Mlave P, Ramsay NKC, Phame F, Cohen E, Perry GS, Goldman AI, Kersey J: A prospective study of infectious diseases following bone marrow transplantation: emergence of Aspergillus and Cytomegalovirus as the major causes of mortality. Infect Control 4:81–89, 1983.

    PubMed  CAS  Google Scholar 

  25. Digregorio MW, Lee MW, Ries CA: Candida infections in patients with acute leukemia: ineffectiveness of nystatin prophylaxis and relationship between oropharyngeal and systemic candidiasis. Cancer 50:2780–2784, 1982.

    Google Scholar 

  26. Meyers JD, Flournoy N, Thomas ED: Infection with herpes simplex virus and cell mediated immunity after marrow transplant. J Infect Dis 142:338–346, 1980.

    PubMed  CAS  Google Scholar 

  27. Atkinson K, Meyers JD, Storb R, Prentice RL, Thomas ED: Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. Transplantation 29:47–50, 1980.

    PubMed  CAS  Google Scholar 

  28. Greenberg MS, Cohen SG, Mitrick JC, Cassileth PA: The oral flora as a source of septicemia in patients with acute leukemia. Oral Surg 53:32–36, 1982.

    PubMed  CAS  Google Scholar 

  29. Peterson DE, Overholser CD, Schimpff SC, Williams LT, Newman KA: Relationship of intensive oral hygiene to systemic complications in acute leukemia. Proc Am Fed Clin Res 29:440A, 1981.

    Google Scholar 

  30. Sullivan KM, Parkman R: The pathophysiology and treatment of graft-versus-host disease. Clin Haematol 12:775–789, 1983.

    PubMed  CAS  Google Scholar 

  31. Sullivan KM: Special care of the allogeneic marrow transplant patient. In: Wiernik PH, Canellos G, Kyle RA, Shiffer CA (eds) Neoplastic diseases of the blood. New York, Churchill Livingstone 1985, pp 1117–1140.

    Google Scholar 

  32. Biggs JC, Atkinson K, Hayes J, Ralston M, Concannon AJ, Dodds AJ: After allogeneic bone marrow transplantation, cyclosporin-A is associated with faster engraftment, less mucositis, and three distinct syndromes of nephrotoxicity when compared to methotrexate. Transplant Proc 15:1487–1489, 1983.

    Google Scholar 

  33. Deeg HJ, Storb R, Thomas ED, Kennedy MS, Flournoy N, Buckner CD, Clift R, Doney K, Sale G, Sanders J, Witherspoon R: Marrow transplantation for acute nonlymphoblastic leukemia in first remission: preliminary results of a randomized trial comparing cyclosporine and methotrexate for prophylaxis of graft- versus-host disease. Transplant Proc 15:1385–1388, 1983.

    Google Scholar 

  34. Lockhart PB, Sonis ST: Relationship of oral complications to peripheral blood leukocyte and platelet counts in patients receiving cancer chemotherapy. Oral Surg 48:21–28, 1979.

    PubMed  CAS  Google Scholar 

  35. Daeffler R: Oral hygiene measures for patients with cancer (I—II). Cancer Nurs 3:347–356 and 427–432, 1980.

    PubMed  CAS  Google Scholar 

  36. Daeffler R: Oral hygiene measures for patients with cancer (III). Cancer Nurs 4:29–35, 1981.

    PubMed  CAS  Google Scholar 

  37. Johnson DW: Sinus disease in an immnno-suppressed population. Presented at American Society of Head and Neck Radiology Meeting, Los Angeles, California, 1981.

    Google Scholar 

  38. Nalesnik MA, Myerowitz RL, Jenkins R, Lenkey J, Herbert D: Significance of Aspergillus species isolated from respiratory secretions in the diagnosis of invasive pulmonary aspergillosis. J Clin Microbiol 11:370–376, 1980.

    PubMed  CAS  Google Scholar 

  39. Meyers JD, Thomas ED: Infection complicating bone marrow transplantation. In: Rubin RH, Young LS (eds) Clinical approach to infection in the compromised host. New York, Plenum, 1981, pp 507–551.

    Google Scholar 

  40. Monald GB, Sharma P, Sale G, Shulman H, Hackman R, Meyers J: Infectious esophagitis in immunosuppressed patients after marrow transplantation. Gastroenterology 82:1127, 1982.

    Google Scholar 

  41. Helm JF, Dodds WJ, Pelc LR, Palmer DW, Hogan WJ, Teeter BC: Effect of esophageal emptying and saliva on clearance of acid from the esophagus. N Engl J Med 310:284–288, 1984.

    PubMed  CAS  Google Scholar 

  42. Petrokubi RJ, Jeffries GH: Cimetidine versus antacid in scleroderma with reflux esophagitis: a randomized double-blind controlled study. Gastroenterology 77:691–695, 1979.

    PubMed  CAS  Google Scholar 

  43. Sullivan KM, Storb R, Shulman HM, Shaw Cheng-Mei, Spence A, Beckham C, Clift RA, Buckner CD, Stewart P, Thomas ED: Immediate and delayed neurotoxicity after mechlor- ethamine preparation for bone marrow transplantation. Ann Intern Med 97:182–189, 1982.

    PubMed  CAS  Google Scholar 

  44. Kay HEM, Knapton PJ, O’Sullivan JP, Wells DG, Harris RF, Innes EM, Stuart J, Schwartz FCM, Thompson EN: Encephalopathy in acute leukemia associated with methotrexate therapy. Arch Dis Child 47:344–354, 1972.

    PubMed  CAS  Google Scholar 

  45. Hedley D, Powles RL, Morgenstern GR: Toxicity of cyclosporin-A in patients following bone marrow transplantation. In: White DJ G (ed) Cyclosporin A. Amsterdam, Elsevier, 1982, pp 345–351.

    Google Scholar 

  46. Atkinson K, Biggs J, Darveniza P, Boland J, Concannon A, Dodds A: Cyclosporine- associated central-nervous-system toxicity after allogeneic bone-marrow transplantation [letter]. N Engl J Med 310:527, 1984.

    PubMed  CAS  Google Scholar 

  47. Wade JC, Meyers JD: Neurologic symptoms associated with parenteral acyclovir treatment after marrow transplantation. Ann Intern Med 98:921–925, 1983.

    PubMed  CAS  Google Scholar 

  48. Deeg HJ, Storb R, Thomas ED: Bone marrow transplantation: a review of delayed complications. Br J Haematol 57:185–208, 1984.

    PubMed  CAS  Google Scholar 

  49. Atkinson K, Clink H, Lawler S, Lawson DN, McElwain TJ, Thomas P, Peckham MJ, Po wies R, Mann JR, Cameron AH, Arthur K: Encephalopathy following bone marrow transplantation. Eur J Cancer 13:623–625, 1977.

    PubMed  CAS  Google Scholar 

  50. Thomas ED, Storb R, Buckner CD: Total body irradiation in preparation for marrow engraftment. Transplant Proc 8:591–593, 1976.

    PubMed  CAS  Google Scholar 

  51. Thomas ED, Cronkite EP: Radiation injury. In: Isselbacher KJ, Adams RD, Braunwald E, et al. (eds) Harrison’s principles of internal medicine, 9th edn. New York, McGraw-Hill, 1980 pp 941–945.

    Google Scholar 

  52. Jack MK, Hicks JD: Ocular complications in high-dose chemoradiotherapy and marrow transplantation. Ann Ophthalmol 13:709–711, 1981.

    PubMed  CAS  Google Scholar 

  53. Jack MK, Jack GM, Sale GE, Shulman HM, Sullivan KM: Ocular manifestations of graftversus-host disease. Arch Ophthamol 101: 1080–1084, 1983.

    CAS  Google Scholar 

  54. Fass L, Ochs HD, Thomas ED, Mickelson E, Storb R, Fefer A: Studies of immunological reactivity following syngeneic or allogeneic marrow grafts in man. Transplantation 16:630–640, 1973.

    PubMed  CAS  Google Scholar 

  55. Elfenbein GJ, Anderson PN, Humphrey RL, Mullins GM, Sensenbrenner LL, Wands JR, Santos GW: Immune system reconstitution following allogeneic bone marrow transplantation in man: a multiparameter analysis. Transplant Proc 8:641–646, 1976.

    PubMed  CAS  Google Scholar 

  56. Noel, DR, Witherspoon RP, Storb R, Atkinson K, Doney K, Mickelson EM, Ochs HD, Warren RP, Weiden PL, Thomas ED: Does graft-versus-host disease influence the tempo of immunologic recovery after allogeneic human marrow transplantation? An observation on 56 long-term survivors. Blood 51:1087–1105, 1978.

    PubMed  CAS  Google Scholar 

  57. Witherspoon RP, Dopecky K, Storb RF, Flournoy N, Sullivan KM, Sosa R, Deeg HJ, Ochs HD, Cheever MA, Fefer A, Thomas ED: Immunological recovery in 48 patients following syngeneic marrow transplantation for hematological malignancy. Transplantation 33:143–149, 1982.

    PubMed  CAS  Google Scholar 

  58. Witherspoon RP, Storb R, Ochs HD, Flournoy N, Kopecky KJ, Sullivan KM, Deeg HJ, Sosa R, Noel DR, Atkinson K, Thomas ED: Recovery of antibody production in human allogeneic marrow graft recipients: influence of time post-transplantation, the presence or absence of chronic graft-versus-host disease, and anti- thymocyte globulin treatment. Blood 58:360–368, 1981.

    PubMed  CAS  Google Scholar 

  59. Sosa R, Weiden PL, Storb R, Syrotuck J, Thomas ED: Granulocyte function in human allogeneic marrow graft recipients. Exp Hematol 8:1183–1189, 1980.

    PubMed  CAS  Google Scholar 

  60. Friedrich W, O’Reilly RJ, Koziner B, Gebhard DF, Good RA, Evans RL: Tlymphocyte re- constitution in recipients of bone marrow transplants with and without GVHD: imbalances of T-cell subpopulations having unique regulatory and cognitive function. Blood 59:696–701, 1982.

    PubMed  CAS  Google Scholar 

  61. Atkinson K, Hansen J A, Storb R, Goehle S, Goldstein G, Thomas ED: T-cell subpopulations identified by monoclonal antibodies after human marrow transplantation. I. Hel- per-inducer and cytotoxic-suppressor subsets. Blood 59:1292–1298, 1982.

    PubMed  CAS  Google Scholar 

  62. Livant S, Seigneuret M, Storb R, Prentice RL: Analysis of cytotoxic effector cell function in patients with leukemia or aplastic anemia before or after marrow transplantation. J Immunol 124:481–490, 1980.

    Google Scholar 

  63. Ringden O, Witherspoon R, Storb R, Ekelund E, Thomas ED: B-cell function in human marrow transplant recipients assessed by direct and indirect hemolysis-in-gel assays. J Immunol 123:2729–2734, 1979.

    PubMed  CAS  Google Scholar 

  64. Lum L, Seigneuret M, Storb RF, Witherspoon RP, Thomas ED: In vitro regulation of im- munoglobin synthesis after marrow transplantation. I. T-cell and B-cell deficiencies in patients with and without chronic graft-versus- host disease. Blood 58:431–439, 1981.

    PubMed  CAS  Google Scholar 

  65. Witherspoon RP, Lum LG, Storb R, Thomas ED: In vitro regulation of immunoglobin synthesis after human marrow transplantation. II. Deficient T and non-T-lymphocyte function within 3–4 months of allogeneic, syngeneic, or autologous marrow grafting for hematologic malignancy. Blood 59:844–850, 1982.

    PubMed  CAS  Google Scholar 

  66. Winston IJ, Schiffman G, Wang DC, Feig SA, Lin CH, Marso EL, Ho WG, Young LS, Gale RP: Pneumococcal infections after human marrow transplantation. Ann Intern Med 91:835–841, 1979.

    PubMed  CAS  Google Scholar 

  67. Neiman PE, Reeves W, Ray G, Flournoy N, Lerner KG, Sale GE, Thomas ED: A prospective analysis of interstitial pneumonia and opportunistic viral infection among recipients of allogeneic bone marrow grafts. J Infect Dis 136:754–767, 1977.

    PubMed  CAS  Google Scholar 

  68. Meyers JD, Leszczynski J, Zaia JA, Flournoy N, Newton B, Snydman D, Wright GG, Levin MJ, Thomas ED: Successful prevention of cytomegalovirus infection after marrow transplant with cytomegalovirus immune globulin. Ann Intern Med 98:442–446, 1983.

    PubMed  CAS  Google Scholar 

  69. Elfenbein GJ, Saral R: Infectious disease during immune recovery after bone marrow transplantation. In: Allen JC (ed) Infection and the compromised host: clinical correlation and therapeutics. Baltimore, Williams and Wilkins, 1981, pp 157–196.

    Google Scholar 

  70. Brown LR, Dreizen S, Handler S, Johnston DA: Effect of radiation-induced xerostomia on human oral microflora. J Dent Res 54:740–750, 1975.

    PubMed  CAS  Google Scholar 

  71. Schubert MM, Sullivan KM, Izutzu KT, et al.: Oral manifestations of chronic graft-versus-host disease. Arch Intern Med 144:1591–1595, 1984.

    PubMed  CAS  Google Scholar 

  72. Sullivan KM, Shulman HM, Storb R, Weiden PL, Witherspoon RP, Monald GB, Schubert MM, Atkinson K, Thomas ED: Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression. Blood 57: 267–276, 1981.

    PubMed  CAS  Google Scholar 

  73. Sale GE, Shulman HM, Schubert MM, Sullivan KM, Kopecky KJ, Hackman RC, Morton TH, Storb R, Thomas ED: Oral and ophthalmic pathology of graft-versus-host disease in man: predictive value of the lip biopsy. Hum Pathol 12:1022–1030, 1981.

    PubMed  CAS  Google Scholar 

  74. Gratwhol AA, Moutsopoulos HM, Chused TM, Akizuki M, Wolf RO, Sweet JB, Deisseroth AB: Sjögren-type syndrome after allogeneic bone marrow transplantation. Ann Intern Med 87:703–706, 1977.

    PubMed  Google Scholar 

  75. Izutsu KT, Truelove EL, Schubert MM, Ensign WY, Meadows EE: Does graft-versus-host disease cause hyposalivation in bone marrow transplant recipients? Proc J Dent Res 61:263, 1982.

    Google Scholar 

  76. Izutsu KT, Schubert MM, Shulman H, Oberg S, Sullivan KM, Rice J, Morton T, Truelove EL: Salivary changes in graft-versus-host disease (GVHD). Proc J Dent Res 59-A:401, 1980.

    Google Scholar 

  77. Izutsu KT, Schubert MM, Truelove EL, Shulman HM, Sale GE, Morton TH, Ensign WY, Mersai T, Sullivan KM, Oberg S, Thomas ED: The predictive value of elevated labial saliva sodium concentration: its relation to labial gland pathology in bone marrow transplant recipients. Hum Pathol 14:29–35, 1983.

    PubMed  CAS  Google Scholar 

  78. Izutsu KT, Sullivan KM, Schubert MM: Disordered salivary immunoglobin secretion and sodium transport in human chronic graft- versus-host disease. Transplantation 35:441–446, 1983.

    PubMed  CAS  Google Scholar 

  79. Sullivan KM, Storb R, Flournoy N, Shulman HM, Weiden PL, Thomas ED: Day-100 screening studies predict the development of chronic graft-versus-host disease (GVHD) [abstr]. Blood 58:17a, 1981.

    Google Scholar 

  80. Monald GB, Sullivan KM, Schuffler MD, Schuffler MD, Shulman HM, Thomas ED: Esophageal abnormalities in chronic graft- versus-host disease. Gastroenterology 80:914–921, 1981.

    Google Scholar 

  81. Monald GB, Sullivan KM, Plumley TF: Radiographic features of esophageal involvement in chronic graft-versus-host disease. AJR 142:501–506, 1984.

    Google Scholar 

  82. Shulman HM, Sullivan KM, Weiden PL, Monald GB, Striker GE, Sale GE, Hackman R, Tsoi MS, Storb R, Thomas ED: Chronic graft-versus-host syndrome in man: a long- term clinicopathologic study of 20 Seattle patients. Am J Med 69:204–217, 1980.

    PubMed  CAS  Google Scholar 

  83. Lawlay TJ, Peck GL, Moutsopoulos HM, Gratwohl AA, Deisseroth AB: Scleroderma, Sjögren-like syndrome, and chronic graft- versus-host disease. Ann Intern Med 87:707–709, 1977.

    Google Scholar 

  84. Atkinson K, Farewell V, Storb R, Tsoi MS, Sullivan KM, Witherspoon RP, Fefer A, Clift R, Goodell B, Thomas ED: Analysis of late infections after human bone marrow transplantation: role of genotypic non-identity between marrow donor and recipient and of nonspecific suppressor cells in patients with chronic graft- versus-host disease. Blood 60:714–720, 1982.

    PubMed  CAS  Google Scholar 

  85. Witherspoon RP, Lum LG, Storb R: Immunologic reconstitution after marrow grafting. Semin Hematol 21:2–10, 1984.

    PubMed  CAS  Google Scholar 

  86. Demetrakopoulos GE, Tsokos GC, Levine AS: Recovery of splenic function after GVHD- associated functional aplenia. Am J Hematol 12:77–80, 1982.

    PubMed  CAS  Google Scholar 

  87. Atkinson K, Storb R, Prentice RL, Weiden PL, Witherspoon RP, Sullivan K, Noel D, Thomas ED: Analysis of infections in 89 long-term survivors of bone marrow transplantation. Blood 53:720–731, 1979.

    PubMed  CAS  Google Scholar 

  88. Stewart PS, Buckner CD, Clift RA, Sanders JE, Storb R, Leonard JM, Thomas ED: Allogeneic marrow grafting for acute leukemia: a follow- up of long-term survivors. Exp Hematol 7:509–518, 1979.

    PubMed  CAS  Google Scholar 

  89. Sullivan KM, Deeg HJ, Sanders JE, Shulman HM, Witherspoon RP, Doney K, Apelbaum FR, Schubert MM, Stewart P, Springmeyer S, Monald GB, Storb R, Thomas ED: Late complications after marrow transplantation. Semin Hematol 21:53–63, 1984.

    PubMed  CAS  Google Scholar 

  90. Sanders JE, Buckner CO, Leonard JM, Sullivan KM, Witherspoon RP, Deeg HJ, Storb R, Thomas ED: Late effects on gonadal function of cyclophosphamide, total-body-irradiation, and marrow transplantation. Transplantation 36: 252–255, 1983.

    PubMed  CAS  Google Scholar 

  91. Sullivan KM, Dahlberg S, Storb R, Meyers J, Witherspoon R, Deeg HJ, Doney K, Appel- baum FR, Thomas ED: Infection acquisition and prophylaxis in chronic graft-versus-host disease (GVHD) [abstr]. Blood 62:230, 1983.

    Google Scholar 

  92. Franklin RM, Kenyon KR, Tutscka PJ, Sarai R, Green WR, Santos GW: Ocular manifestations of graft-vs-host disease. Ophthalmology 90:4–13, 1983.

    PubMed  CAS  Google Scholar 

  93. Deeg HS, Flournoy N, Sullivan KM, Sheehan K, Buckner CD, Sanders JE, Storb R, Witherspoon RP, Thomas ED: Cataracts after total body irradiation and marrow transplantation: a sparing effect of dose fractionation. Int J Radiat Oncol Biol Phys 10:957–964, 1984.

    PubMed  CAS  Google Scholar 

  94. Sklar CA, Kim TH, Ramsay NKC: Thyroid dysfunction among long term survivors of bone marrow transplant. Am J Med 73:688–694, 1982.

    PubMed  CAS  Google Scholar 

  95. Thomas ED: The experience with #x201C;late effects#x201D; after marrow transplantation. In: Fliedner TM, Gossner W, Patrick G (eds) Radiation protection: late effects after therapeutic whole-body irradiation. Luxembourg, Office for Official Publications of the European Communities, 1983 pp 11–15.

    Google Scholar 

  96. Deeg HJ, Storb R, Prentice R, Fritz TE, Weiden PL, Sale GE, Graham TC, Thomas ED: Increased cancer risk in canine radiation chimeras. Blood 55:233–239, 1980.

    PubMed  CAS  Google Scholar 

  97. Sanders J, Sale GE, Ramberg R, Clift R, Buckner CD, Thomas ED: Glioblastomas multiforme in a patient with acute lymphoblastic leukemia who received a marrow transplant. Transplant Proc 14:770–774, 1982.

    PubMed  CAS  Google Scholar 

  98. Harrison DT, Flournoy N, Ramberg R, Boyd C, Erne K, Buckner CD, Fefer A, Sanders J, Storb R, Thomas ED: Relapse following marrow transplantation for acute leukemia. Am J Hematol 5:191–202, 1978.

    PubMed  CAS  Google Scholar 

  99. Badger C, Buckner CD, Thomas ED, Clift RA, Sanders JE, Stewart PS, Storb R, Sullivan KM, Shulman H, Flournoy N: Allogeneic marrow transplantation for acute leukemia in relapse. Leuk Res 6:383–387, 1982.

    PubMed  CAS  Google Scholar 

  100. Thomas ED, Clift RA, Hershman J, Sanders JE, Stewart P, Buckner CD, Fefer A, Muffin R, Smith JW, Storb R: Marrow transplantation for acute nonlymphoblastic leukemia in first remission using fractionated or single-dose irradiation. Int J Radiat Oncol Biol Phys 8:817–821, 1982.

    PubMed  CAS  Google Scholar 

  101. Mathe G, Amiel JL, Schwarzenberg L, Cattan A, Schneider M: Adoptive immunotherapy of acute leukemia: experimental and clinical results. Cancer Res 25:1525–1531, 1965.

    PubMed  CAS  Google Scholar 

  102. Odom LF, August CS, Githens JH, Humbert JR, Morse H, Peakman D, Sharma B, Rusnak SL, Johnson FB: Remission of relapsed leukemia during a graft-versus-host reaction: a #x201C;graft-versus-leukemia reaction#x201D; in man? Lancet 2:537–540, 1978.

    PubMed  CAS  Google Scholar 

  103. Weiden PL, Flournoy N, Thomas ED, Prentice R, Fefer A, Buckner CD, Storb R: Antileukemic effect of graft-versus-host disease in human recipients of allogeneic marrow grafts. N Engl J Med 300:1068–1073, 1979.

    PubMed  CAS  Google Scholar 

  104. Weiden PL, Sullivan KM, Flournoy N, Storb R, Thomas ED: Antileukemic effect of chronic graft-versus-host diseases: contribution to improved survival after allogeneic marrow transplantation. N Engl J Med 304:1529–1533, 1981.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Mark M. Schubert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Keith M. Sullivan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Edmond L. Truelove
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Oral Diagnosis Baltimore College of Dental Surgery Dental School, University of Maryland, 21201, Baltimore, Maryland, USA

    Douglas E. Peterson D.M.D., Ph.D. (Associate Professor) (Associate Professor)

  2. Program of Oncology, University of Maryland, School of Medicine, 21201, Baltimore, Maryland, USA

    Douglas E. Peterson D.M.D., Ph.D. (Associate Professor) (Associate Professor)

  3. University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA

    E. George Elias M.D., Ph.D. (Professor of Surgery and Oncology, Director of Surgical Oncology) (Professor of Surgery and Oncology, Director of Surgical Oncology)

  4. Division of Dentistry, Brigham and Women’s Hospital, 75 Francis Street, 02115, Boston, Massachusetts, USA

    Stephen T. Sonis D.M.D., D.M.Sc. (Chief, Associate Professor) (Chief, Associate Professor)

  5. Department of Oral Medicine and Oral Pathology, Harvard School of Dental Medicine, 02115, Boston, Massachusetts, USA

    Stephen T. Sonis D.M.D., D.M.Sc. (Chief, Associate Professor) (Chief, Associate Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Schubert, M.M., Sullivan, K.M., Truelove, E.L. (1986). Head and Neck Complications of Bone Marrow Transplantation. In: Peterson, D.E., Elias, E.G., Sonis, S.T. (eds) Head and Neck Management of the Cancer Patient. Developments in Oncology, vol 36. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2289-4_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2289-4_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9411-5

  • Online ISBN: 978-1-4613-2289-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation