Restoration of Antibody Responsiveness by Endotoxin in Retrovirus-Immunodepressed Mice: Role of Macrophages
Exogenous retroviruses are the cause of severe immunodeficiency syndromes in humans and animals (4). Studies in our laboratory have focused on elucidating the mechanisms underlying the immunodeficiency induced in mice by retroviruses of the Friend leukemia complex (FLC). The pathologies produced by the two viral components of this complex are considerably different. Genetically susceptible mice inoculated with the entire FLC develop a rapidly progressing erythroblastosis of the spleen followed by erythroleukemia within a few weeks postinfection—a series of changes thought to be initiated by the rapidly transforming replication-defective spleen focus-forming virus. In contrast, the slow transforming replication-competent helper virus (F-MuLV), when injected alone into the same strains of mice, causes leukemias of varied histotype after a latency of several months, the only change noticeable during the long incubation period being a slight hyperplasia of the spleen (11,32).
KeywordsAntibody Response Spleen Cell Infected Mouse Responder Cell Friend Virus
Unable to display preview. Download preview PDF.
- 1.J. Ansel, T. A. Luger, A. Kock, D. Kochstein, and I. Green, The effect of in vitro UV irradiation on the production of IL-1 by murine macrophages and cells, J. Immunol. 133: 135 (1984).Google Scholar
- 2.M. Bendinelli, The reticuloendothelial system in infection with RNA tumor viruses, in: “The Reticuloendothelial System: A Comprehensive Treatise, Volume 10, Infection,” M. Escobar and J. P. Utz, eds., Plenum Press, New York and London, in press (1985).Google Scholar
- 4.M. Bendinelli, D. Matteucci, and H. Friedman, Retrovirus-induced acquired immunodeficiencies, Adv. Cancer Res. 45 (1985).Google Scholar
- 5.M. Bendinelli, D. Matteucci, and A. Toniolo, Retrovirus-induced immunodeficiency in mice, in: “Viruses, Immunity and Immunodeficiency,” A. Szentivanyi and H. Friedman, eds., Plenum Press, New York and London (1986).Google Scholar
- 6.M. Bendinelli, D. Matteucci, A. Toniolo, and H. Friedman, Macrophage involvement in leukemia virus-induced tumorigenesis, Adv. Exp. Biol. Med. 121B: 493 (1980).Google Scholar
- 7.M. Bendinelli and L. Nardini, Immunodepression by Rowson-Parr virus in mice. 1. Growth curves of Rowson-Parr virus and immunological relationships with Friend virus, Inf. Immun. 7: 152 (1973).Google Scholar
- 10.R. C. Butler, J. M. Frier, M. S. Chapekar, M. O. Graham, and H. Friedman, Role of antibody response helper factors in immunosuppressive effects of Friend leukemia virus, Infec. Immun. 39: 1260 (1983).Google Scholar
- 18.M. K. Hoffman, S. B. Mizel, and J. A. Hirst, IL-1 requirement for B cell activation revealed by use of adult serum, J. Immunol. 133: 2566 (1984).Google Scholar
- 19.D. D. Isaak, R. M. Miceli, and J. P. Lake, Target cell heterogeneity in muring leukemia virus infection. III. Identification of susceptible Lyt 1+ and resistant Lyt 2+ T cell subsets following in vitro infection with Friend murine leukemia virus, Cell. Immunol. 88: 464 (1984).PubMedCrossRefGoogle Scholar
- 23.R. N. Moore, K. J. Goodrum, and L. J. Berry, Mediation of endotoxin effect by macrophages, J. Reticuloendothelial Soc. 19: 187 (1976).Google Scholar
- 26.A. Nowotny, ed., “Beneficial Effects of Endotoxins,” Plenum Press, New York and London (1983).Google Scholar
- 32.R. Weiss, N. Teich, H. Varmus, and J. Coffin, eds., “Molecular Biology of Tumor Viruses: RNA Tumor Viruses,” Second Edition, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (1982).Google Scholar