Restoration of Antibody Responsiveness by Endotoxin in Retrovirus-Immunodepressed Mice: Role of Macrophages
Exogenous retroviruses are the cause of severe immunodeficiency syndromes in humans and animals (4). Studies in our laboratory have focused on elucidating the mechanisms underlying the immunodeficiency induced in mice by retroviruses of the Friend leukemia complex (FLC). The pathologies produced by the two viral components of this complex are considerably different. Genetically susceptible mice inoculated with the entire FLC develop a rapidly progressing erythroblastosis of the spleen followed by erythroleukemia within a few weeks postinfection—a series of changes thought to be initiated by the rapidly transforming replication-defective spleen focus-forming virus. In contrast, the slow transforming replication-competent helper virus (F-MuLV), when injected alone into the same strains of mice, causes leukemias of varied histotype after a latency of several months, the only change noticeable during the long incubation period being a slight hyperplasia of the spleen (11,32).
KeywordsToxicity Depression Leukemia Recombinated Polysaccharide
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