Skip to main content
SpringerLink
Log in

The Antigenic Structure of the Lipooligosaccharides of Neisseria Gonorrhoeae

  • Chapter
Book cover Immunobiology and Immunopharmacology of Bacterial Endotoxins

Part of the book series: University of South Florida International Biomedical Symposia Series ((EMISS,volume 18))

  • 137 Accesses

Abstract

The importance of lipooligosaccharide (LOS) (this term which will be used in this chapter in place of “lipopolysacharide” was suggested by Schneider et al. (29) for the lipid A containing glycolipids of pathogenic Neisseria because of the oligosaccharide nature of the saccharide moiety in these organisms) in the pathogenesis and immunobiology of Neisseria gonorrhoeae is unquestioned. Studies by Ward et al. (32), Rice and Kasper (27) and Schneider and co-workers (28) indicate the LOS is a key target on the gonococcal cell surface for human bactericidal antibody. Thus, an understanding of the physicochemical and antigenic structure of gonococcal LOS as well as its characteristics in vivo and in vitro will be important in comprehending the immunobiology of the gonococcus.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. P. Z. Allen, M. C. Connelly, and M. A. Apicella, Interactions of lectins with Neisseria gonorrhoeae, Canadian J. Microbiol. 26: 468 (1980).

    Article  CAS  Google Scholar 

  2. M. A. Apicella and J. C. Allen, Isolation and characterization of the beta antigen of Neisseria gonorrhoeae, Infect. and Immun. 7: 315 (1973).

    CAS  Google Scholar 

  3. M. A. Apicella, Antigenically distinct populations of Neisseria gonorrhoeae: isolation and characterization of the responsible determinants, J. Infect. Dis. 130: 619 (1974).

    Article  CAS  Google Scholar 

  4. M. A. Apicella, Serogrouping of Neisseria gonorrhoeae: identification of four immunologically distinct acidic polysaccharides, J. Infect. Dis. 134: 377 (1976).

    Article  CAS  Google Scholar 

  5. M. A. Apicella, J. F. Breen, and N. C. Gagliardi, Pegradation of the polysaccharide component of gonococcal lipopolysaccharide of gonococcal and meningococcal sonic extracts, Infect, and Immun. 20: 228 (1978).

    CAS  Google Scholar 

  6. M. A. Apicella and N. Gagliardi, Antigenic heterogeneity of the non-serogroup antigen structure of the lipopolysaccharides of Neisseria gonorrhoeae, Infect, and Immun. 26: 870 (1979).

    CAS  Google Scholar 

  7. M. A. Apicella, Lipopolysaccharide-derived serotype polysaccharides from Neisseria meningitidis group B, J. Infect. Pis. 140: 62 (1979).

    Article  CAS  Google Scholar 

  8. M. A. Apicella, K, M. Bennet, C. A. Hermerath, and P. E. Roberts, Monoclonal antibody analysis of lipopolysaccharide from Neisseria gonorrhoeae and Neisseria meningitidis, Infect. Immun. 34: 751 (1981).

    PubMed  CAS  Google Scholar 

  9. J. F. Breen and M. A. Apicella, Immunogenicity of gonococcal Gc2 polysaccharide: comparative studies with pneumonococcal type III polysaccharide, and Salmonella typhosa Vi antigen, Infect. and Immun. 22:195 (1978).

    CAS  Google Scholar 

  10. M. C. Connelly and P. Z. Allen, Chemical and immunochemical studies on lipopolysaccharides from pyocin 103 sensitive and resistant Neisseria gonorrhoeae, Carbohydrate Research 120: 171 (1983).

    Article  PubMed  CAS  Google Scholar 

  11. L. F. Guymon, M. Esser, and W. M. Shafer, Pyocin-resistant lipopolysaccharide mutants of Neisseria gonorrhoeae: alterations in sensitivity to normal human serum and polymyxin B, Infect, and Immun. 36: 541 (1982).

    CAS  Google Scholar 

  12. B. Jann, K. Reski, and K. Jann, Heterogeneity of lipopolysaccharides. Analysis of polysaccharide chain lengths by sodium dodecylsulfate- polyacrylamide gel electrophoresis, Eur. J. Biochem. 60: 239 (1975).

    Article  PubMed  CAS  Google Scholar 

  13. J. A. Maeland, Antigenic properties of various preparations of Neisseria gonorrhoeae endotoxin, Acta. Path. Microbiol. Scan. 73: 413 (1968).

    Article  CAS  Google Scholar 

  14. J. A. Maeland, Antigenic determinants of aqueous ether extracted endotoxin from Neisseria gonorrhoeae, Acta. Path. Microbiol. Scan. 76: 475 (1969).

    Article  CAS  Google Scholar 

  15. J. A. Maeland, Antibodies in human sera against antigens in gonococci, demonstrated by a passive hemolysis test, Acta. Path, et Microbiol. Scand 67: 102 (1966).

    CAS  Google Scholar 

  16. J. A. Maeland, Serological properties of antisera to Neisseria gonorrhoeae antigens, Acta. Path. Microbiol. Scand. 69: 145 (1967).

    Article  Google Scholar 

  17. J. A. Maeland, Immunochemical characterization of aqueous ether extracted endotoxin from Neisseria gonorrhoeae, Acta. Path. Microbiol. Scand. 76: 484 (1969).

    Article  PubMed  CAS  Google Scholar 

  18. J. A. Maeland, Serological cross-reactions of aqueous ether extracted endotoxin from Neisseria gonorrhoeae strains, Acta. Path. Microbiol. Scand 77: 505 (1969).

    Article  PubMed  CAS  Google Scholar 

  19. J. A. Maeland and T. Kristoffersen, Immunochemical investigations on Neisseria gonorrhoeae endotoxin. I. Characterization of phenol-water extracted endotoxin and comparison with aqueous ether preparations, Acta. Path. Microbiol. Scand. Sec. B: 226 (1971).

    Google Scholar 

  20. J. A. Maeland, T. Kristofferson, and T. Hofstad, Immunochemical investigations on Neisseria gonorrhoeae endotoxin. II. Serological multispecificity of other properties of phenol-water preparations, Acta. Path. Microbiol. Scand. Sec. B: 233 (1971).

    Google Scholar 

  21. S. A. Morse and M. A. Apicella, Isolation of a lipopolysaccharide mutant of Neisseria gonorrhoeae: an analysis of the antigenic and biologic differences, J. Infect. Dis. 145:206 (1982).

    Article  PubMed  CAS  Google Scholar 

  22. S. A. Morse, C. S. Mintz, S. K. Sarafran, L. Bartenstein, M. Bertram, and M. A. Apicella, Effect of dilution rate on lipopolysaccharide and serum resistance of Neisseria gonorrhoeae grown in continuous culture, Infect. and Immun. 41: 74 (1983).

    CAS  Google Scholar 

  23. M. P. Perry, V. Pauost, B. B. Piena, E. Ashton, and R. Wallace, The lipopolysaccharides of Neisseria gonorrhoeae colony types 1 and 4, Can. J. Biochem. 53: 623 (1975).

    PubMed  CAS  Google Scholar 

  24. M. D. Perry, V. Pauost, V. G. Johnson, B. B. Piena, and F. E. Ashton, Gonococcal R-type lipopolysaccharides, in: “Immunobiology of Neisseria Gonorrhoeae”, ASM Publications, Washington, P.C. (1978).

    Google Scholar 

  25. R. Rappuoli, Purification of gonococcal R Type lipopolysaccharide not bearing the lactose-like antigen, Giorn. Batt. Virol. Immun. 74: 191 (1981).

    CAS  Google Scholar 

  26. R. Rappuoli, Production and characterization of high titer rabbit antigonococcal R-type lipopolysaccharide serum, Microbiologica 5: 225 (1982).

    PubMed  CAS  Google Scholar 

  27. P. A. Rice and D. Kasper, Characterization of gonococcal antigens responsible for induction of bactericidal antibody in disseminated infection, J. Clin. Invest. 60: 1149 (1977).

    Article  PubMed  CAS  Google Scholar 

  28. H. Schneider, J. M. Griffis, G. D. Williams, and G. B. Pier, Immunological basis of serum resistance to Neisseria gonorrhoeae, J. Gen. Microbiol 128: 13 (1982).

    PubMed  CAS  Google Scholar 

  29. H. Schneider, T. L. Hale, W. D. Zollinger, R. C. Seid, C. A. Hammack, and J. M. Griffis, Heterogeneity of molecular size and antigenic expression within lipooligosaccharide of individual strains of Neisseria gonorrhoeae and Neisseria meningitidis, Infect, and Immun. 45: 544 (1984).

    CAS  Google Scholar 

  30. A. Stead, S. S. Main, M. E. Ward, and P. J. Walt, Studies on lipopolysaccharides isolated from strains of Neisseria gonorrhoeae, J. Gen. Microbiol. 88: 123 (1975).

    PubMed  CAS  Google Scholar 

  31. H. Tauber and W. Garson, Isolation of lipopolysaccharide endotoxin, Biol. Chem 235: 961 (1959).

    Google Scholar 

  32. M. E. Ward, P. R. Lambden, J. E. Heckels, and P. J. Ward, The surface properties of Neisseria gonorrhoeae: determinants of susceptibility to antibody complement killing, J. Gen. Micro. 108: 205 (1978).

    CAS  Google Scholar 

  33. G. M. Wiseman and J. D. Caird, Composition of the lipopolysaccharide of Neisseria gonorrhoeae, Infect, and Immun. 16: 550 (1977).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, State University of New York at Buffalo, School of Medicine, Buffalo, New York, USA

    Michael A. Apicella

Authors
  1. Michael A. Apicella
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Andor Szentivanyi (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) & Herman Friedman (Professor and Chairman) (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) &  (Professor and Chairman)

  2. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Apicella, M.A. (1986). The Antigenic Structure of the Lipooligosaccharides of Neisseria Gonorrhoeae. In: Szentivanyi, A., Friedman, H., Nowotny, A. (eds) Immunobiology and Immunopharmacology of Bacterial Endotoxins. University of South Florida International Biomedical Symposia Series, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2253-5_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2253-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9319-4

  • Online ISBN: 978-1-4613-2253-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation