Abstract
In 1954 Westphal and his associates reported on the isolation of a moiety of bacterial endotoxin which they liberated by means of hydrolysis in dilute acetic or hydrochloric acid solutions (25). The water soluble phase of the hydrolysis reaction contained a haptenic polysaccharide which no longer retained the ability to stimulate physiological responses characteristic of the starting material (3,4). On the other hand, the hydrolysis products extractable with organic solvents did retain some of the endotoxic properties of the original substance, leading Westphal and coworkers to postulate that the “endotoxic” activities of LPS were attributable to a lipidic component, which they designated lipid A (5).
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© 1986 Plenum Press, New York
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Ribi, E., Cantrell, J.L., Takayama, K., Ribi, H.O., Myers, K.R., Qureshi, N. (1986). Modulation of Humoral and Cell-Mediated Immune Responses by a Structurally Established Nontoxic Lipid A. In: Szentivanyi, A., Friedman, H., Nowotny, A. (eds) Immunobiology and Immunopharmacology of Bacterial Endotoxins. University of South Florida International Biomedical Symposia Series, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2253-5_36
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DOI: https://doi.org/10.1007/978-1-4613-2253-5_36
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