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Molecular Mechanisms in Lymphokine-Induced Macrophage Activation-Enhanced Production of Oxygen Radicals

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Immunobiology and Immunopharmacology of Bacterial Endotoxins

Part of the book series: University of South Florida International Biomedical Symposia Series ((EMISS,volume 18))

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Abstract

Macrophages (MPs) are key effector cells in the eradication of a variety of unicellular or multicellular pathogens and, most likely, in the limitation of malignant growth. The principal cytotoxic mechanism of MPs is exerted on microorganisms internalized by phagocytosis such as bacteria, fungi and protozoa. A second mechanism is represented by damage inflicted to extracellular targets ranging from tumor cells to large metazoan parasites. In addition, MPs exhibit suppressor activity on cells of the immune system, such as T lymphocytes.

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Author information

Authors and Affiliations

  1. Laboratory of Immunopharmacology, Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Edgar Pick

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  1. Edgar Pick
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Editors and Affiliations

  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Andor Szentivanyi (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) & Herman Friedman (Professor and Chairman) (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) &  (Professor and Chairman)

  2. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1986 Plenum Press, New York

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Pick, E. (1986). Molecular Mechanisms in Lymphokine-Induced Macrophage Activation-Enhanced Production of Oxygen Radicals. In: Szentivanyi, A., Friedman, H., Nowotny, A. (eds) Immunobiology and Immunopharmacology of Bacterial Endotoxins. University of South Florida International Biomedical Symposia Series, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2253-5_30

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  • DOI: https://doi.org/10.1007/978-1-4613-2253-5_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9319-4

  • Online ISBN: 978-1-4613-2253-5

  • eBook Packages: Springer Book Archive

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