Beneficially Active Structural Entities in Endotoxin Preparations

  • Alois Nowotny
Part of the University of South Florida International Biomedical Symposia Series book series (EMISS, volume 18)


The effects of endotoxin preparations can be divided into two large groups. One consists of reactions which are harmful and may lead to irreversible vascular collapse, shock and death. The other covers those which are beneficial, such as enhanced immune responsiveness, elevated non-specific resistance to microbial infections including fungi and viruses, increased leukopoiesis, activation of lymphocytes and of the functions of macrophages as well as of the entire reticuloendothelial system. Finally, one should mention the anti-tumor effects of endotoxins on some established animal malignancies and the resistance enhancement to transplantable experimental tumors induced by endotoxin. Table 1 shows some of those endotoxic effects which may be considered as beneficial.


Colony Stimulation Factor Serratia Marcescens Bacterial Endotoxin Lipid Moiety Split Product 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Alois Nowotny
    • 1
  1. 1.Center for Oral Health ResearchUniversity of PennsylvaniaPhiladelphiaUSA

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