Myocardial Performance and Adrenergic Modulation of Cyclic AMP Following Endotoxin Administration

  • Raymond E. Shepherd
  • Charles H. Lang
  • Brent A. Brumfield
  • Norman W. Robie
  • Karen R. DuSapin
  • Kathleen H. McDonough
Part of the University of South Florida International Biomedical Symposia Series book series (EMISS, volume 18)


Myocardial contractility may change in response to altered circulatory demands imposed by physiological stimuli. Many studies have explored the behavior of cardiac contraction during shock of various etiologies. In the final phase of circulatory shock, clinical signs of circulatory insufficiency are indicated by low peripheral perfusion, low mean arterial blood pressure, high heart rate, and central venous congestion. A point is reached in the progression of the syndrome where fatal cardiovascular collapse occurs.


Adenylate Cyclase Plasma Catecholamine Endotoxin Shock Endotoxin Administration Peak Systolic Pressure 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Raymond E. Shepherd
    • 1
  • Charles H. Lang
    • 1
  • Brent A. Brumfield
    • 1
  • Norman W. Robie
    • 2
  • Karen R. DuSapin
    • 2
  • Kathleen H. McDonough
    • 1
  1. 1.Departments of PhysiologyLouisiana State University Medical CenterNew OrleansUSA
  2. 2.Pharmacology and Experimental TherapeuticsLouisiana State University Medical CenterNew OrleansUSA

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