Skip to main content
SpringerLink
Log in

Myocardial Performance and Adrenergic Modulation of Cyclic AMP Following Endotoxin Administration

  • Chapter
Book cover Immunobiology and Immunopharmacology of Bacterial Endotoxins

Part of the book series: University of South Florida International Biomedical Symposia Series ((EMISS,volume 18))

  • 131 Accesses

Abstract

Myocardial contractility may change in response to altered circulatory demands imposed by physiological stimuli. Many studies have explored the behavior of cardiac contraction during shock of various etiologies. In the final phase of circulatory shock, clinical signs of circulatory insufficiency are indicated by low peripheral perfusion, low mean arterial blood pressure, high heart rate, and central venous congestion. A point is reached in the progression of the syndrome where fatal cardiovascular collapse occurs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R. D. Aarons and P.B. Molinoff, Changes in the density of beta-adrenergic receptors in rat lymphocytes, heart, and lung after chronic treatment with propranolol, Pharmacol. Exptl. Ther. 221: 439 (1981).

    Google Scholar 

  2. R. D. Aarons, A. S. Nies, J. G. Gerber, and P. B. Molinoff, Decreased beta-adrenegic receptor density on human lymphocytes after chronic treatment with agonists, J. Pharmacol. Exptl. Ther. 224: 1 (1982).

    Google Scholar 

  3. H. R. Adams, C. R. Baxter, J. L. Parker, and N. B. Watts, Contractile function and rhythmicity of cardiac preparations from E. coli endotoxin-shocked guinea pigs, Circ. Shock 13: 241 (1984).

    PubMed  CAS  Google Scholar 

  4. L. T. Archer, B. A. Benjamin, B. K. Beller-Todd, D. J. Brackett, M. F. Wilson, and L. B. Hinshaw, Does LD coli shock cause myocardial failure? Circ. Shock 9: 7 (1982).

    PubMed  CAS  Google Scholar 

  5. C. R. Benedict and D. G. Grahame-Smith, Plasma noradrenaline and adrenaline concentrations and dopamine-beta-hydroxylase activity in patients with shock due to septicaemia, trauma and hemorrhage, Quart. J. Med. 185: 1 (1978).

    Google Scholar 

  6. B. L. Brown, J. D. M. Albano, R. P. Ekins, A. M. Sgherzi, and A. L. Tampion, A simple and sensitive saturation assay method for the measurement of adenosine 3′5′-cyclic monophosphate, Biochem. J. 121: 561 (1971).

    PubMed  CAS  Google Scholar 

  7. W. S. Colucci, R. W. Alexander, G. H. Williams, R. E. Rude, B. L. Holman, M. A. Konstam, J. Wayne, G. H. Mudge, and E. Braunwald, Decreased lymphocyte beta-adrenergic receptor density in patients with heart failure and tolerance to the beta-adrenergic agonist, Pirbuterol. N. Eng. J. Med. 305 (1981).

    Google Scholar 

  8. S. E. Epstein and E. Braunwald, The effect of beta adrenergic blockade on patterns of urinary sodium excretion: studies in normal subjects and in patients with heart disease, Ann. Intern. Med. 65: 20 (1966).

    PubMed  CAS  Google Scholar 

  9. R. D. Feldman, L. E. Limbird, J. Nadeau, D. Robertson, A. J. J. Wood, Leukocyte beta-receptor alterations in hypertensive subjects, J. Clin. Invest. 73: 648 (1984).

    Article  PubMed  CAS  Google Scholar 

  10. R. D. Feldman, L. E. Limbird, J. Nadeau, G. H. Fitzgerald, D. Robertson, and A. J. J. Wood, Dynamic regulation of leukocyte beta-adrenergic receptor-agonist interactions by physiological changes in circulating catecholamines, Clin. Invest. 72: 164 (1983).

    Article  CAS  Google Scholar 

  11. R. E. Fish, A. H. Burns, C. H. Lang, and J. A. Spitzer, Myocardial dysfunction in a non-lethal, non-shock model of chronic endotoxemia, Circ. Shock 16 (1985).

    Google Scholar 

  12. T. J. Franklin, W. P. Morris, and P. A. Twose, Densensitization of beta-adrenergic receptors in human fibroblasts in tissue culture, Mol. Pharmacol. 11: 485 (1975).

    CAS  Google Scholar 

  13. J. Fraser, J. Nadeau, J. D. Robertson, and A. J. J. Wood, Regulation of human leukocyte beta receptors by endogenous catecholamines. Relationship of leukocyte beta receptor density to the cardiac sensitivity to isoproterenol, Clin. Invest. 67: 1777 (1984).

    Google Scholar 

  14. T. E. Gaffney and E. Braunwald, Importance of the adrenergic nervous system in the support of circulatory function in patients with congestive heart failure, Am. Med. 34: 320 (1963).

    Article  CAS  Google Scholar 

  15. R. P. Gilbert, Mechanisms of the hemodynamic effects of endotoxin, Physiol. Rev. 40: 245 (1960).

    PubMed  CAS  Google Scholar 

  16. A. G. Gilman, A protein kinase binding assay for adenosine 3′,5′-cyclic monophosphate, Proc. Natl. Acad. Sci. USA 67: 305 (1970).

    Article  PubMed  CAS  Google Scholar 

  17. R. D. Goldfarb, Cardiac dynamics following shock: role of circulating cardiodepressant substances, Circ. Shock 9: 317 (1982).

    PubMed  CAS  Google Scholar 

  18. R. D. Goldfarb, W. Tambolini, S. M. Wiener, and P. B. Weber, Caninen left ventricular performance during LD endotoxemia, Am. J. Physiol. 244: H370 (1983).

    PubMed  CAS  Google Scholar 

  19. T. K. Harden, Y. F. Su, and J. P. Perkins, Catecholamine-induced desensitization involved in uncoupling beta-adrenergic receptors and adenylate cyclase, J. Cyclic Nucleotide Res. 5: 99 (1979).

    PubMed  CAS  Google Scholar 

  20. D. C. Harrison, Effects of beta-blockade on circulatory dynamics, in: “Beta-Adrenergic Blockade: A New Era in Cardiovascular Medicine,” E. Braunwald, ed., Excerpta Medica, Amsterdam (1978).

    Google Scholar 

  21. M. L. Hess, Subcellular function in the acutely failing myocardium, Circ. Shock 6: 119 (1979).

    PubMed  CAS  Google Scholar 

  22. M. L. Hess and S. M. Krause, Contractile protein dysfunction as a determinant of depressed cardiac contractility during endotoxin shock, J. Mol. Cardiol. 12:715 (1981).

    Article  Google Scholar 

  23. M. L. Hess, A. Hastillo, and L. J. Greenfield, Spectrum of cardiovascular function during gram-negative sepsis, Prog. Cardiovascular Dis. 23: 279 (1981).

    Article  CAS  Google Scholar 

  24. L. B. Hinshaw, Role of the heart in the pathogenesis of endotoxin shock: a review of the clinical findings and observations on animal species, J. Surg. Res. 17: 134 (1974).

    Article  PubMed  CAS  Google Scholar 

  25. L. B. Hinshaw, L. T. Archer, J. J. Spitzer, M. R. Black, M. D. Peyson, and L. J. Greenfield, Effects of coronary hypotension and endotoxin on myocardial performance, Am. J. Physiol. 227: 1051 (1974).

    PubMed  CAS  Google Scholar 

  26. L. B. Hinshaw, B. Benjamin, L. T. Archer, and M. D. Payton, The heart and endotoxin shock, Tex. Rep. Biol. Med. 39: 173 (1979).

    PubMed  CAS  Google Scholar 

  27. L. B. Hinshaw, Overview of endotoxin shock, in: “Pathophysiology of Shock, Anoxia and Ischemia,” R. A. Cowley and B. F. Trump, eds., Williams and Wilkins, Baltimore (1982).

    Google Scholar 

  28. P. Hjemdahl, M. Daleskog, and T. Kahan, Determination of plasma catecholamines by high-performance liquid chromatography with electro-chemical detection: Comparison with a radioenzymatic method, Life Sciences 25: 131 (1979).

    Article  PubMed  CAS  Google Scholar 

  29. M. J. Hoffman, L. J. Greenfield, H. J. Sugerman, and J. L. Taturm, Unsuspected right ventricular dysfunction in shock and sepsis, Ann. Surg. 198: 307 (1983).

    Article  PubMed  CAS  Google Scholar 

  30. S. B. Jones and F. D. Romano, Plasma catecholamine in the conscious rat during endotoxicosis, Circ. Shock 14: 189 (1984).

    PubMed  CAS  Google Scholar 

  31. G. L. Johnson, B. B. Wolfe, T. K. Harden, P. B. Molinoff, and J. P. Perkins, Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells, J Biol. Chem. 253: 1472 (1978).

    PubMed  CAS  Google Scholar 

  32. A. M. Katz, Role of the contractile proteins and sarcoplasmic reticulum in the response of the heart to catecholamine: a historic review, Adv. Cyclic Nucleotide Res. 11: 303 (1979).

    PubMed  CAS  Google Scholar 

  33. R. S. Kent, A. Delean, and R. J. Lefkowitz, A quantitative analysis of beta adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modelling of ligand binding data, Mol. Pharmacol 17: 14 (1980).

    PubMed  CAS  Google Scholar 

  34. J. F. Krall, M. Connelly, and M. L. Tuck, Acute regulation of beta adrenergic catecholamine sensitivity in human lymphocytes, J Pharmacol. Exptl. Ther. 214: 554 (1980).

    CAS  Google Scholar 

  35. E. Lachman, S. B. Pitsoe, and S. L. Goffin, Anti-lipopolysaccharide immunotherapy in management of septic shock of obstetric and gynaecological origin, Lancet 8384: 981 (1984).

    Article  Google Scholar 

  36. C. H. Lang, G. J. Bagby, and J. J. Spitzer, Glucose kinetics and body temperature after lethal and nonlethal doses of endotoxin, Am. J. Physiol. 248: R000 (1985).

    Google Scholar 

  37. A. M. Lefer and M. J. Rovetto, Influence of myocardial depressant factor on physiologic properties of cardiac muscle, Proc. Soc. Exp. Biol. Med. 134: 269 (1970).

    PubMed  CAS  Google Scholar 

  38. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, Protein measurement with the folin phenol reagent, J. Biol. Chem. 193: 265 (1951).

    PubMed  CAS  Google Scholar 

  39. J. McCaig, K. A. Kane, G. Bailey, P. F. Millington, and J. R. Parratt, Myocardial function in feline endotoxin shock: a correlation between myocardial contractility, electrophysiology, and ultrastructure, Circ. Shock 6: 201 (1979).

    PubMed  CAS  Google Scholar 

  40. K. H. McDonough, C. H. Lang, and J. J. Spitzer, Depressed function of isolated hearts from hyperdynamic, septic rats. Circ. Shock 12; 241 (1984).

    PubMed  CAS  Google Scholar 

  41. J. Montini, G. J. Bagby, A. H. Burns, and J. J. Spitzer, Am. J. Physiol. 240: H659 (1981).

    PubMed  CAS  Google Scholar 

  42. J. R. Neely, H. Liebermeister, E. J. Battersby, and H. E. Morgan, Effect of pressure development on oxygen consumption by isolated rat heart, Am. J. Physiol. 212: 804 (1967).

    PubMed  CAS  Google Scholar 

  43. J. L. Parker and H. R. Adams, Myocardial effects of endotoxin shock: characterization of an isolated heart muscle model, Adv. Shock Res. 2: 163 (1979).

    PubMed  CAS  Google Scholar 

  44. J. L. Parker and H. R. Adams, Contractile dysfunction of atrial myocardium from endotoxin-shocked guinea pigs, Am. J. Physiol 240: 11954 (1981).

    Google Scholar 

  45. M. Pollack, A. I. Huang, R. K. Prescott, L. S. Young, K. W. Hunter, D. F. Cruess, and C.-M. Tsai, Enhanced survival in Pseudomonas aeruginosa septicemia associated with high levels of circulating antibody to E. coli endotoxin core, Clin. Invest. 72: 1874 (1983).

    Article  CAS  Google Scholar 

  46. J. Postel and P. R. Schloerb, Cardiac depression in bacteremia, Ann. Surg. 186: 74 (1977).

    Article  PubMed  CAS  Google Scholar 

  47. J. Raffa and D. D. Trunkey, Myocardial depression in sepsis, J. Trauma 18: 617 (1978).

    Article  PubMed  CAS  Google Scholar 

  48. E. Remold-O’Donnell, Stimulation and desensitization of macrophage adenylate cyclase by prostaglandins and catecholamines, Biol. Chem. 249: 3615 (1974).

    Google Scholar 

  49. G. A. Robison, R. W. Butcher, I. Oye, H. E. Morgan, and E. W. Sutherland, The effect of epinephrine on adenosine 3′,5′-phosphate levels in isolated perfused rat heart, Mol. Pharmacol. 1: 168 (1965).

    PubMed  CAS  Google Scholar 

  50. A. J. Romanosky, A. H. Burns, and R. E. Shepherd, In vitro myocardial performance following in vivo administration of E. coli endotoxin, Fed. Proc. 42:608 (1983).

    Google Scholar 

  51. E. M. Ross and A. G. Gilman, Biochemical properties of hormone-sensitive adenylate cyclase, Ann. Rev. Biochem. 49: 533 (1980).

    Article  PubMed  CAS  Google Scholar 

  52. G. Scatchard, The attractions of proteins for small molecules and ions, Ann. N.Y Acad. Sci. 51: 660 (1949).

    Article  CAS  Google Scholar 

  53. M. Shear, P. Insel, K. L. Melmon, and P. Coffino, Agonist specific refractoriness induced by isoproterenol. Studies with mutant cells, J. Biol. Chem. 251: 7572 (1976).

    PubMed  CAS  Google Scholar 

  54. R. E. Shepherd, K. H. McDonough, and A. H. Burns, Mechanism of cardiac dysfunction in hearts from endotoxin-treated rats, Circ. Shock 13: 95 (1984).

    Google Scholar 

  55. J. H. Siegel, F. B. Cerra, B. Coleman, I. Giocannini, M. Shetye, J. R. Border, and R. H. McMenamy, Physiological and metabolic correlation in human sepsis, Surgery 86: 163 (1979).

    PubMed  CAS  Google Scholar 

  56. J. F. Spann, E. H. Sonneblick, T. Cooper, C. A. Chidsey, V. L. William, and E. Braunwald, Cardiac norepinephrine stores and the contractile state of heart muscle, Circ. Res. 19: 317 (1966).

    PubMed  CAS  Google Scholar 

  57. J. J. Spitzer, Studies of substrate metabolism in isolated myocytes, in: “Myocardial Injury,” J. J. Spitzer, ed., Plenum Publishing Corporation, New York (1983).

    Chapter  Google Scholar 

  58. G. L. Stiles, M. G. Caron, and R. J. Lefkowitz, Beta-adrenergic receptors: biochemical mechanisms of physiological regulation, Physiol. Rev. 64: 661 (1984).

    PubMed  CAS  Google Scholar 

  59. T. E. Temples, A. H. Bums, F. C. Nance, and H. I. Miller, Effect of burn shock on myocardial function in guinea pigs, Circ. Shock 14: 81 (1984).

    PubMed  CAS  Google Scholar 

  60. C. S. Thomas, M. A, Melly, M. G. Koenig, and S. K. Brockman, The hemodynamic effects of viable gram-negative organisms, Surg. Gynecol. Obstet. 128: 753 (1969).

    PubMed  Google Scholar 

  61. J. P. Weisul, T. F. O’Donnell, M. A. Stone, and G. H. Clowes, Myocardial performance in clinical septic shock: effects of isoproterenol and glucose potassium insulin, J. Surg, Reg, 18: 357 (1975).

    Article  CAS  Google Scholar 

  62. E. J. Winslow, H. S. Loeb, S. Kamath, and R. M. Gunnar, Hemodynamic studies and results of therapy in 50 patients with bacteremic shock, Am. J. Med. 54: 421 (1973).

    Article  PubMed  CAS  Google Scholar 

  63. E. J. Ziegler, J. A. McCutchan, J. Furer, M. P. Glauser, J. C. Scadoff, H. Douglas, and A. I. Braude, Treatment of gram-negative bacteremia and shock with human antiserum to mutant Escherichia coli, N. Eng. J. Med. 307: 1225 (1982).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Physiology, Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Raymond E. Shepherd, Charles H. Lang, Brent A. Brumfield & Kathleen H. McDonough

  2. Pharmacology and Experimental Therapeutics, Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Norman W. Robie & Karen R. DuSapin

Authors
  1. Raymond E. Shepherd
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles H. Lang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Brent A. Brumfield
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Norman W. Robie
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Karen R. DuSapin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kathleen H. McDonough
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Andor Szentivanyi (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) & Herman Friedman (Professor and Chairman) (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) &  (Professor and Chairman)

  2. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Shepherd, R.E., Lang, C.H., Brumfield, B.A., Robie, N.W., DuSapin, K.R., McDonough, K.H. (1986). Myocardial Performance and Adrenergic Modulation of Cyclic AMP Following Endotoxin Administration. In: Szentivanyi, A., Friedman, H., Nowotny, A. (eds) Immunobiology and Immunopharmacology of Bacterial Endotoxins. University of South Florida International Biomedical Symposia Series, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2253-5_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2253-5_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9319-4

  • Online ISBN: 978-1-4613-2253-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation