Abstract
The liver plays a key role in the systemic response of a body to endotoxin exposure. The liver is not only a important site of metabolism and metabolic regulation, but it is composed of a large capillary bed rich in macrophages, the Kupffer cells. This sinusoidal network may contain at any time up to twenty percent of the circulating blood volume. The liver is responsible for clearing greater than ninety percent of endotoxin presented to it as an exogenous bolus (6,10,14), and it most likely also responsible for intermittently filtering endotoxin arising from the bacterial-infested gut into the portal vein under various pathological conditions (6,14). It is demonstrated that blockade of the liver’s reticuloendothelial system of macrophages can potentiate the systemic injury of endotoxin (6). On the other hand, endotoxin is also known to have a number of effects on macrophages directly, which are capable of producing secondary and possible injurious effects themselves (1,4,11,15). A variety of possible endotoxin-cellular interactions, particularly those with macrophages, might tip the balance toward the ultimate benefit or detriment of the organ in which they occur and the organism at large. The current study explores the endotoxin-macrophage interaction in the context of the liver.
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© 1986 Plenum Press, New York
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Latham, P.S., Sepelak, S.B. (1986). Endotoxin (LPS) Toxicity to Hepatocytes (H) In Vitro - Modulation by Macrophages (M). In: Szentivanyi, A., Friedman, H., Nowotny, A. (eds) Immunobiology and Immunopharmacology of Bacterial Endotoxins. University of South Florida International Biomedical Symposia Series, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2253-5_12
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DOI: https://doi.org/10.1007/978-1-4613-2253-5_12
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