Advertisement

The Cellular Physiology of Isolated Outer Hair Cells: Implications for Cochlear Frequency Selectivity

  • Jonathan F. Ashmore
Part of the Nato ASI Series book series (NSSA, volume 119)

Abstract

There is a substantial, if circumstantial, weight of evidence which points to the outer hair cells (OHC) as the cellular elements involved in active hearing mechanisms. The interpretation of experiments involving efferent stimulation (Brown and Nuttall, 1984), acoustic emission (Hubbard and Mountain, 1983), ototoxic drug lesions and noise is that OHC are actively involved in cochlear micromechanics. In addition, it is now known that OHC isolated from the organ of Corti exhibit motile properties, (Brownell et al.,1985). Nevertheless, the forces generated by OHC in vivo must be sufficiently large and must be generated at a high enough rate to control macroscopic mechanics, or, equivalently, to produce the appropriate mechanical basilar membrane impedance required in theoretical models of the cochlea (Neely, 1983).

Keywords

Hair Cell Outer Hair Cell Voltage Clamp Basilar Membrane Cuticular Plate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ashmore, J. F. (1985). Measurements of hair cell movement using a linear position detector, J.Physiol., 264, 4 P.Google Scholar
  2. Ashmore, J. F. and Meech, R. W. (1986). Three distinct potassium channels in outer hair cells isolated from the guinea-pig cochlea, J.Physiol., 371, 29 P.Google Scholar
  3. Brown, M. C. and Nuttall, A. L. (1984). Efferent control of cochlear inner hair cell responses in the guinea pig, J.Physiol., 354, 625–646PubMedGoogle Scholar
  4. Brownell, W. E., Bader, C. R., Bertrand, D. and de Ribaupierre, Y. (1985). Evoked mechanical responses of isolated cochlear outer hair cells, Science, 227, 194–196.PubMedCrossRefGoogle Scholar
  5. Cody, A. R. and Russell, I. J. (1985). Outer hair cells in the mammalian cochlea and noise-induced hearing loss, Nature, 315, 662–665.PubMedCrossRefGoogle Scholar
  6. Flock, A. (1983). Hair cells,receptors with a motor capacity? in: Hearing - Physiological Bases and Psychophysics, R. Klinke and R. Hartmann eds., Springer-Verlag, BerlinGoogle Scholar
  7. Gummer, A. W. and Johnstone, B, M. (1981). Direct measurement of the basilar membrane stiffness in the guinea pig, J.Acoust. Soc. Am., 70, 1298–1309.CrossRefGoogle Scholar
  8. Howard, J. and Ashmore, J. F. (1986). The stiffness of the sensory hair bundle, Hearing Res. (In the Press).Google Scholar
  9. Hubbard, A. L. and Mountain, D. C. (1983). Alternating sound delivered into the scala media alters sound pressure at the ear-drum, Science, 222, 510–512.PubMedCrossRefGoogle Scholar
  10. Miller, C. E. (1985). Structural implications of basilar membrane compliance measurements, J.Acoust.Soc Am. 77, 1465–1474.PubMedCrossRefGoogle Scholar
  11. Neely, S. T. (1983). The cochlear amplifier, in: The Mechanics of Hearing, E. de Boer and M.A.Viergever, eds., Martinus Nijhoff, Delft.Google Scholar
  12. Ohmori, H. (1985). Mechanoelectric-transduction currents in isolated vestibular hair cells, J.Physiol., 359, 189–218.PubMedGoogle Scholar
  13. Sellick, P. M.,Patuzzi R. and Johnstone B. M. (1982). Measurement of basilar membrane motion in the guinea pig using the Mossbauer technique, J. Acoust. Soc. Am., 72, 131–141.PubMedCrossRefGoogle Scholar
  14. Strelioff, D. and Flock, A. (1984). Stiffness of sensory hair bundles in the isolated guinea pig cochlea, Hearing Res., 15, 19–28.CrossRefGoogle Scholar
  15. Zenner, H. P.,Zimmerman, U., Schmidt, U. (1985). Reversible control of isolated mammalian cochlear hair cells, Hearing Res., 18, 127–134.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jonathan F. Ashmore
    • 1
  1. 1.Department of Physiology, Medical SchoolUniversity WalkBristolUK

Personalised recommendations