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Amyloidosis pp 385-389 | Cite as

Genetic Heterogeneity of Familial Amyloid Polyneuropathies of Jewish Type

  • Mordechai Pras
  • Frances Prelli
  • Joseph Gafni
  • Blas Frangione

Abstract

The Jewish SKO amyloid protein is a prealbumin monomer with two amino acid substitutions. Glycine is substituted for Threonine at position 49 and Isoleucine for Phenylalanine at position 33. The distribution of these components is different in thyroid and spleen suggesting tissue specificifity in amyloid disposition. The SKO variant differs from the prealbumin proteins found in the Portuguese, Japanese and Swedish Familial Amyloid Polyneuropathies. Additional prealbumin variants will be expected when the amyloid proteins of the facial and upper limb amyloid neuropathies as well as the Van Allen kinship can be studied.

Keywords

Amino Acid Substitution Amyloid Deposit Amyloid Fibril Cyanogen Bromide Systemic Amyloidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Mordechai Pras
    • 1
  • Frances Prelli
    • 2
  • Joseph Gafni
    • 1
  • Blas Frangione
    • 2
  1. 1.Sheba Medical CenterHeller InstituteIsrael
  2. 2.Department of PathologyNew York University Medical CenterNew YorkUSA

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