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Amyloidosis pp 385–389Cite as

Genetic Heterogeneity of Familial Amyloid Polyneuropathies of Jewish Type

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Abstract

The Jewish SKO amyloid protein is a prealbumin monomer with two amino acid substitutions. Glycine is substituted for Threonine at position 49 and Isoleucine for Phenylalanine at position 33. The distribution of these components is different in thyroid and spleen suggesting tissue specificifity in amyloid disposition. The SKO variant differs from the prealbumin proteins found in the Portuguese, Japanese and Swedish Familial Amyloid Polyneuropathies. Additional prealbumin variants will be expected when the amyloid proteins of the facial and upper limb amyloid neuropathies as well as the Van Allen kinship can be studied.

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Author information

Authors and Affiliations

  1. Sheba Medical Center, Heller Institute, Tel-Hashomer, Israel

    Mordechai Pras & Joseph Gafni

  2. Department of Pathology, New York University Medical Center, 550 First Avenue, New York, N. Y., 10016, USA

    Frances Prelli & Blas Frangione

Authors
  1. Mordechai Pras
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  2. Frances Prelli
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  3. Joseph Gafni
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  4. Blas Frangione
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Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    George G. Glenner

  2. Columbia University, New York, New York, USA

    Elliott F. Osserman

  3. University of Washington, Seattle, Washington, USA

    Earl P. Benditt

  4. State University of New York at Buffalo, Buffalo, New York, USA

    Evan Calkins

  5. Boston University School of Medicine, Boston, Massachusetts, USA

    Alan S. Cohen

  6. New York University School of Medicine, New York, New York, USA

    Dorothea Zucker-Franklin

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© 1986 Plenum Press, New York

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Pras, M., Prelli, F., Gafni, J., Frangione, B. (1986). Genetic Heterogeneity of Familial Amyloid Polyneuropathies of Jewish Type. In: Glenner, G.G., Osserman, E.F., Benditt, E.P., Calkins, E., Cohen, A.S., Zucker-Franklin, D. (eds) Amyloidosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2199-6_50

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  • DOI: https://doi.org/10.1007/978-1-4613-2199-6_50

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9292-0

  • Online ISBN: 978-1-4613-2199-6

  • eBook Packages: Springer Book Archive

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