Preliminary Results of a Randomized Study of Intrahepatic Infusion versus Systemic Infusion of FUDR for Metastatic Colorectal Carcinoma

  • Nancy Kemeny
  • John Daly


Development of a totally implantable infusion pump produced a renewed interest in hepatic infusional therapy. An initial study employing this pump and continuous hepatic infusion of FUDR produced an 83% response rate1. However, further work with this method brought the mean response rate down to 59%2which, however, is still higher than the mean response rate obtained with systemic chemotherapy.


Systemic Group Extrahepatic Disease Liver Involvement Minor Response Metastatic Colorectal Carcinoma 
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  1. 1.
    Ensminger W., Niederhuber J., Gyves J. Thrall J., Cozzi E., Coan: Effective control of liver metastases from colon cancer with an implanted system for hepatic arterial chemotherapy. Proc ASCO1: 94, 1982.Google Scholar
  2. 2.
    Kemeny N., Daly J., Oderman P., Shike M., Chun H., Petroni G., Geller N.: Hepatic artery pump infusion: Toxicity and results in patients with metastatic colorectal carcinoma. J Clin Oncol2: 595 - 600, 1984.Google Scholar
  3. 3.
    Wood C.B., Gillis C.R., Blumgart L.H.: A retrospective study of the natural history of patients with liver metastases from colorectal cancer. Clin Oncol2: 285–288, 1976.Google Scholar
  4. 4.
    Pettavel J., Morganthaler F.: Protracted arterial chemotherapy of liver tumors: An experience of 107 cases over a 12-year period. In: Ariel IM (ed) Progress in Clinical Cancer. Grune & Stratton, New York, 1978, pp 217–233.Google Scholar
  5. 5.
    Nielsen J., Balslev I., Jensen H.E.: Carcinoma of the colon with liver metastases. Acta Chir Scand137: 463 - 465, 1971.Google Scholar
  6. 6.
    Kemeny N., Braun D.W.: Prognostic factors in advanced colorectal carcinoma. Importance of lactic dehydrogenase level, performance status and white blood cell count. Am J Med74: 786–798, 1983.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Nancy Kemeny
    • 1
  • John Daly
    • 2
  1. 1.Solid Tumor Service Department of MedicineKettering Cancer CenterNew YorkUSA
  2. 2.Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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