Skip to main content
SpringerLink
Log in

Continuous Infusion VP-16, Bolus Cisplatin, and Simultaneous Radiation Therapy as Salvage Therapy in Small Cell Bronchogenic Carcinoma

  • Chapter
Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy

  • 42 Accesses

Abstract

VP-16 is regarded as one of the most active single agents in small cell bronchogenic carcinoma (SCBC). As second line therapy response rates have ranged from 0–40% with a cumulative series response rate of 12% in 381 patients.(1–10)the importance of VP-16 scheduling is suggested by in vitro data revealing enhanced cytotoxicity after prolonged exposure and clinical data showing the benefit of frequent, daily schedules over weekly administration.(11,12)Cisplatin as second line therapy for SCBC has demonstrated significant activity in 8 of 54 patients.(13,14,15)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cohen M, Broder L, Fossieck B, et al. Phase II clinical trial of weekly administration of VP16-213 in small cell bronchogenic carcinoma. Cancer Treat. Rep.61: 489–490, 1977.

    CAS  Google Scholar 

  2. Hansen M, Hirsch F, Dombernowsky P, et al. Treatment of small cell anaplastic carcinoma of the lung with the oral solution of VP16-213. Cancer40: 633, 1977.

    Article  CAS  Google Scholar 

  3. Ossell B, Einhorn L, Comis R, et al. Multicenter phase II trial of etoposide in refractory small cell lung cancer. Cancer Treat. Rep.69: 127–128, 1985.

    Google Scholar 

  4. Antman K, Pomfret E, Kays G, et al. Phase II trial of etoposide in previously treated small cell carcinoma of the lung. Cancer Treat. Rep.68: 1413–1414, 1984.

    CAS  Google Scholar 

  5. Dally M, Harper P, Smyth J, etal. Epipodophyllotoxin (VP-16/213) in small cell carcinoma of the bronchus resistant to initial combined chemotherapy. British jf. of Diseases of the Chest 312, 1980.

    Google Scholar 

  6. Karp G, Antman K, Cannellos G. VP-16-213 a phase II trial using a weekly schedule. Cancer Clin. Trials4: 465–467, 1981.

    CAS  Google Scholar 

  7. Tempero M, Kessinger A, Lemon H. VP-16-213 therapy in patients with small cell carcinoma of the lung after failure on combined chemotherapy. Cancer Clin. Trials4: 155–157, 1981.

    CAS  Google Scholar 

  8. Tucker R, Ferguson A, VanUyk C, et al. Chemotherapy of small cell carcinoma of the lung with VP 16-213. Cancer41: 1710, 1970.

    Article  Google Scholar 

  9. Nissen N, Rajak T, Leone L, et al. Clinical trial of VP 16-213 IV twice weekly in advanced neoplastic disease. Cancer45: 232–235, 1980.

    Article  CAS  Google Scholar 

  10. Eagan R, Carr D, Frytak S, et al. VP-16-213 versus polychemotherapy in patients with advanced small cell lung cancer. Cancer Treat. Rep.60: 949–951, 1976.

    CAS  Google Scholar 

  11. Dombernowsky P and Nissen N. Schedule dependency of the antileukemic activity of the podophyllotoxin derivative VP16-213 in L1210 leukemia. Arch. Path. Micro. Scandinavia81: 715–724, 1981.

    Google Scholar 

  12. Sierocki, J, Hilaris B, Hopfan S, et al. cis-Dichlorodiamineplatinum (II) and VPP-16-213: an active induction regimen for small cell carcinoma of the lung. Cancer Treat. Rep.63: 1593, 1979.

    CAS  Google Scholar 

  13. Dombernowsky P, Sorenson S, Aisner J, et al. Cis-Dichlorodiammineplatinum (II) in small cell anaplastic bronchogenic carcinoma: a phase II study. Cancer Treat. Rep.63: 543–545, 1979.

    CAS  Google Scholar 

  14. Bhuchar V, Canzotti V. High-dose cisplatin for lung cancer. Cancer Treat. Rep.66: 375–376, 1982.

    CAS  Google Scholar 

  15. Cavalli F, Goldhirsch A, Siegenthaler P, et al. Phase II study with cis-dichlorodiammineplatinum (II) in small cell anaplastic bronchgenic carcinoma. European J. of Cancer16: 617–621, 1980.

    CAS  Google Scholar 

  16. Evans W, Osoba D, Feld F, et al. Etoposide (VP-16) and cisplatin: an effective treatment for relapse in small cell lung cancer. J. Clin. Oncol.3 (1): 65–71, 1985.

    CAS  Google Scholar 

  17. Madrigal P, Manga G, Palomero T, et al. VP-16-213 combined with cis-platinum in the treatment of small cell carcinoma of the lung. Cancer Chemo. Pharm. 7: 203–204, 1982.

    CAS  Google Scholar 

  18. Porter L, Johnson D, Hainsworth J, et al. Recurrent small cell lung carcinoma treated with VP-16 and cisplatin. Am. Soc. Clin. Oncol. C-840, 1984.

    Google Scholar 

  19. Tinsley R, Comis R, DiFino S, et al. Potential clinical synergy observed in the treatment of small cell lung cancer with cisplatin and VP-16-213. Proc. Am. Soc. Clin. Oncol. C-772, 1983.

    Google Scholar 

  20. Kim P and McDonald D. The combination of VP-16-213 and cis-platinum in the treatment of small cell carcinoma of the lung. Proc. Am. Soc. Clin. Oncol. C-547, 1982.

    Google Scholar 

  21. Lopez J, Mann J, Grapski R, et al. Salvage chemotherapy of refractory small cell lung cancer with VP-16 and cis-platinum. Am. Soc. Clin. Oncol C-586, 1982.

    Google Scholar 

  22. Evans W, Feld R, Osoba D, et al. VP-16 alone and in combination with cisplatin in previously treated patients with small cell lung cancer. Cancer53: 1461–1466, 1984.

    Article  CAS  Google Scholar 

  23. Ochs J, Tester W, Cohen M, et al. ‘Salvage’ radiation therapy for intrathoracic small cell carcinoma of the lung progressing on combination chemotherapy. Cancer Treat. Rep.67: 1123–1126, 1983.

    CAS  Google Scholar 

  24. Douple E, Richmond, R. A review of platinum complex biochemistry suggests a rationale for combined platinum radiotherapy. Int. J. Rad. One. Biol. Phys.5: 1335–1339, 1979.

    CAS  Google Scholar 

  25. Fu K, Rayner P, Lam K. Modification of the effects of continuous low dose rate irradiation by concurrent chemotherapy infusion. Int. J. Rad. One. Biol. Phys.10: 1477–1478, 1984.

    Google Scholar 

  26. Swartz M, Roseman 3, Gunderson L, et al. Podophyllin increases tumor radioresponsiveness. Cancer Chemo. Pharm.7: 238, 1982.

    Google Scholar 

  27. Morstyn G, Ihde D, Lichter A, et al. Small cell lung cancer 1973–1983: early progress and recent obstacles. Int. J. Rad. Oncol. Biol. Phys.10: 515–539, 1984.

    Article  CAS  Google Scholar 

  28. Murray N, Hadzic E, Shah A, et al. Alternating chemotherapy and thoracic radiotherapy with concurrent cisplatin for limited stage small cell carcinoma of the lung. Proc. Am. Soc. Clin. One. C-835, 1984.

    Google Scholar 

  29. Woods R, Levi, J. Chemotherapy for small cell lung cancer: a randomized study of maintenance therapy with cyclophosphamide, adriamycin, and vincristine after remission induction with cisplatinum, VP-16-213, and radiotherapy. Proc. Am. Soc. Clin. Oncol. C-836, 1984.

    Google Scholar 

  30. Aisner J, Whitacre D, Van Echo D, et al. Doxorubicin, cyclophosphamide, and etoposide (ACE) by bolus or continuous infusion for small cell carcinoma of the lung, Proc. Am. Soc. Clin. One. C-765, 1983.

    Google Scholar 

  31. Willson 3, Neville A, Davis T. A phase II trial of etoposide infusion, cis-platinum, and hexamethylemlamine in small cell carcinoma of the lung. Proc. Am. Soc. Clin. One. C-897, 1984.

    Google Scholar 

  32. Aisner J, VanEcho D, Whitacre M, et al. A phase I trial of continuous infusion VP-16-213 (etoposide). Cancer Chemo. Pharm.7: 157–160, 1982.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Medical Oncology, Rush University, Chicago, IL, USA

    K. Rowland Jr, P. Bonomi, S. Taylor, S. Maffey, S. Reddy & M. S. Lee

Authors
  1. K. Rowland Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Bonomi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Taylor
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Maffey
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Reddy
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. S. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Medical Oncology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, USA

    C. Julian Rosenthal M.D. (Associate Professor of Medicine, Director) (Associate Professor of Medicine, Director)

  2. Department of Radiation Oncology, State University of New York Health Science Center of Brooklyn, Brooklyn, New York, USA

    Marvin Rotman M.D. (Professor and Chairman) (Professor and Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Rowland, K., Bonomi, P., Taylor, S., Maffey, S., Reddy, S., Lee, M.S. (1986). Continuous Infusion VP-16, Bolus Cisplatin, and Simultaneous Radiation Therapy as Salvage Therapy in Small Cell Bronchogenic Carcinoma. In: Rosenthal, C.J., Rotman, M. (eds) Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2197-2_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2197-2_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9291-3

  • Online ISBN: 978-1-4613-2197-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation