Abstract
In 1983 carcinoma of the urinary bladder was responsible for over 10,000 deaths in the United States1. Despite advances in treatment and detection of the disease, this death rate has remained virtually unchanged for the last 30 years. Transurethral resection, partial cystectomy and interstitial implant are appropriate treatments for low grade, low stage tumors, while pre-operative irradiation followed by planned cystectomy is the accepted modality of treatment for high stage, deeply invasive carcinomas. Patients who demonstrate complete response in the surgical cystectomy specimen carry a better prognosis2,3,4,5. Blandy in 1980, showed that patients achieving complete response within 6 months of curative irradiation had a 5 year survival rate of 56%2. Therefore, if the complete response rate can be improved then hopefully this will translate into prolonged survival.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Silverberg E: Cancer Statistics, 1983. CAJan-Feb 33: 9–25, 1983.
Blandy JP, England HR, Evans SJ, Hope-Stone HF, Mair GM, Mantel BS, Oliver RT, Paris AM, Risdon RA: T3 Bladder Cancer - The Case for Salvage Cystectomy. Br J Urol52: 506–510, 1980.
Bloom, HJG, Henry W, Wallace D, Skeet R: Treatment of T3 Bladder Cancer: Controlled Trial of Pre-Operative Radiotherapy and Radical Cystectomy vs Radical Radiotherapy. Second Report and Review Brit J Urol54: 136–151, 1982.
van der Werf-Messing G, Friedeil GH, Menon RS, Hop WCJ, Wassif SB: Carcinoma of the Urinary Bladder T3NXM0 Treated by Pre-operative Irradiation Followed by Cystectomy. Int J Radiat Biol Phys8: 1849–1855, 1982.
Batata MA, Chu FCH, Hilaris BS, Kim YS, Lee MZ, Chung S, Whitmore WF: Factors of Prognostic and Therapeutic Significance in Patients with Bladder Cancer. Int J Radiat Oncol Biol Phys7: 575–579, 1981.
Buroker T, Nirgo N, Considine B, Vaitkevicius VK: Mitomycin-C, 5-fluorouracil, and Radiation Therapy in Squamous (Epidermoid) Cell Carcinoma of Anal Canal. In Mitomycin-C: Current Status and New Developments, SK Carter and ST Crooke Eds, New York, Academic Press, 1979.
Sischy B, Remington JH, Hinson EJ, et al: Definitive Treatment of Anal Canal Carcinoma by Means of Radiation Therapy and Chemotherapy. Disease of Colon and Rectum, 7: 685–688, 1982.
Byfield JE, Barone R, Mendelsohn J, Frankel S, Quinol L, Sharp T, Seagren S: Infusion 5-FU and X-ray Therapy for Nonresectable Esophageal Cancer. Cancer45: 703–708, 1980.
Moertel CG, Childs DS, Jr., Reitemeier RJ, et al: Combined 5- fluorouracil and Supervoltage Radiation Therapy of Locally Unresectable Gastrointestinal Cancer. Lancet2: 865–867, 1969.
Shipley WU, Coombs LJ, Einstein AB, Socoway MS, Wassman Z, Prout George RJR and National Bladder Cancer Collaborative Group A: Cisplatin and Full Dose Irradiation for Patients with Invasive Bladder Carcinoma: A Preliminary Report of Tolerance and Local Response. The J of Urol132: 899–903, 1984.
Byfield JE, Calabro Jones P, Klisak I, Kulhanian F: Pharmacologic Requirements for Obtaining Sensitization of Human Tumor Cells in vitro to Combined 5-f luorouracil or Ftorafar and X-rays. Int J Radiat Oncol Biol Phys8: 1923–1933, 1982.
Phillips TL, and Fu KK: Quantification of Combined Radiation Therapy and Chemotherapy Effects on Critical Normal Tissue, Cancer37: 1186–1200, 1976.
Heidelberger C, Greisbach L, Montag BJ, Mooren D, Cruz D, Schnitzer RJ, Grunberg E: Studies in Fluorinated Pyrimidin II. Effects of Transplanted Tumor. Ca Res. 18: 305–317, 1958.
Vermund H, Hodgett J, Ansfield FJ: Effects of Combined Chemotherapy on Transplanted Tumor in Mice. Amer J Roentgen85: 559–567, 1961.
Vietti J., Eggerding F., Valeriote F: Combined Effect of Radiation and 5-fluorouracil on Survival of Transplanted Leukemia Cells. J Natl Ca Inst47: 865–870, 1971.
Seifert P, Baker LH, Reed ML: Comparison of Continuous Infused 5-FU with Bolus Injection in Treatment of Patients with Colorectal Adenocarcinoma. Cancer36: 123–128, 1975.
Early K, Elias EG, Mittleman A. et al: Mitomycin C in the Treatment of Metastatic Transitional Cell Carcinoma of the Bladder. Cancer31: 1150–1153, 1973.
Soloway MS: Surgery and Intravesical Chemotherapy in the Management of Superficial Bladder Cancer. Seminars in Urol1: 23–33, 1983.
Goodman GB, Hislop TG, Elwood JM, Balfour J: Conservation of Bladder Function in Patients with Invasive Bladder Cancer Treated by Definitive Irradiation and Selective Cystectomy. Int J Radiat Oncol Biol Phys7: 569–573, 1982.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Rotman, M. et al. (1986). Treatment of Bladder Carcinoma with Concomitant Infusion Chemotherapy and Irradiation. In: Rosenthal, C.J., Rotman, M. (eds) Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2197-2_18
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2197-2_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9291-3
Online ISBN: 978-1-4613-2197-2
eBook Packages: Springer Book Archive