An Uncontrolled Phase II Study of Constant Infusion Vincristine-Adriamycin

Abstract

The combination of adriamycin and vincristine administered as bolus injections have antitumoral activity in pediatric cases; however there are no published reports of concomitant constant infusion vincristine and adriamycin. Due to their short serum half-life, it seems reasonable that an improvement in their therapeutic index might occur if these drugs were given as a continuous infusion. In support of this, there is published evidence of reduced cardiotoxic effects in adults for adriamycin when it was administered as a constant effusion (1). We considered it reasonable to evaluate the clinical effects of the combination administered as a constant infusion in patients who were considered refractory to these same drugs given as bolus injections.