Abstract
Contemporary discussions of immunity in man usually center on various forms of cellular and humoral response. However, bacteria, fungi, protozoa and tumor cells need iron for their growth. A response of the mammalian host to infection and possibly also to the growth of tumor cells is to deny to the invading agent and replicating cells the iron present in the host. Weinberg (1) has prepared a comprehensive analysis of the relation of iron and iron-binding proteins to what has been referred to as “nutritional immunity.” Additional references will be found in his paper.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
E. D. Weinberg, Iron withholding: a defense against infection and neoplasia, Physiological Reviews 64: 65 (1984).
A. L. Schade and L. Caroline, An iron-binding component in human blood plasma, Science 104: 340 (1946).
M. Worwood, Ferritin in human tissues and serum, Clinics in Hematology 11: 275 (1982).
J. W. Drysdale, T. G. Adelman, P. Arosio, D. Casarcale, P. Fitzpatrick, J. T. Hazard, and M. Yokota, Human isoferritins in normal and disease states, Seminars in Hematology 14: 71 (1977).
R. Pearl, Cancer and tuberculosis, Am. J. Hyg. 9: 97 (1929).
H. C. Nauts, The apparently beneficial effects of bacterial infection on host resistance to cancer: end results in 435 cases, Cancer Res. Inst. Monograph 8: 1 (1958).
B. S. Blumberg, B. J. S. Gerstley, D. A. Hungerford, W. T. London, and A. I. Sutnick, A serum antigen (Australia antigen) in Down’s syndrome, leukemia and hepatitis, Ann. Int. Med. 66: 924 (1967).
A. I. Sutnick, W. T. London, B. S. Blumberg, and B. J. S. Gerstley, Persistent anicteric hepatitis with Australia antigen in patients with Down’s syndrome, Am. J. Clin. Path. 57: 2 (1972).
A. J. Kolk-Vegter, E. Bosch, and A. M. Leeuwen, Influence of serum hepatitis on haemoglobin level in patients on regular haemodialysis, Lancet 1: 526 (1971).
A. I. Sutnick, B. S. Blumberg, and E. Lustbader, Elevated serum iron levels and persistent Australia antigen (HBsAg), Ann. Int. Med. 81: 855 (1974).
B. S. Blumberg, B. Larouze, W. T. London, B. Werner, J. E. Hesser, I. Millman, G. Saimot, and M. Payet, The relation of infection with the hepatitis B agent to primary hepatic carcinoma, Am. J. Pathol. 81: 669 (1975).
W. T. London and B. S. Blumberg, Hepatitis B and related viruses in chronic hepatitis, cirrhosis and hepatocellular carcinoma in man and animals in: “Chronic Active Liver Disease,” S. Cohen and R. D. Soloway, eds., Churchill Livingstone, New York (1982).
C. Felton, E. D. Lustbader, C. Merten, and B. S. Blumberg, Serum iron levels and response to hepatitis B virus, Proc. Natl. Acad. Sci. USA 76: 2438 (1979).
A. Vierucci, W. T. London, B. S. Blumberg, A. I. Sutnick and F. Ragazzini, Australia antigen and antibody in transfused children with thalassemia, Arch. Dis. Childhood 47: 760 (1972).
W. T. London and J. S. Drew, Sex differences in response to hepatitis B infection among patients receiving chronic dialysis treatment, Proc. Natl. Acad. Sci. USA 74: 2561 (1977).
S. Mazzur, J. Corbett, and B. S. Blumberg, Loss of immunologic reactivities of Australia antigen after incubation with bacteria, Proc. Soc. Exp. Biol. Med. 142: 327 (1973).
I. Millman, H. Hutanen, F. Merino, M. E. Bayer, and B. S. Blumberg, Australia antigen: physical and chemical properties, Res. Commun. Chem. Path. Pharm. 2: 667 (1971).
E. Feret, B. S. Blumberg, P. Whitford, and E. Lustbader, Serum iron levels and the response to infection with hepatitis B virus in the population of Tip, Senegal, West Africa, in preparation (1984).
B. S. Blumberg, E. D. Lustbader, and P. L. Whitford, Changes in serum iron levels due to infection with hepatitis B virus, Proc. Natl. Acad. Sci. USA 78: 3222 (1981).
J. S. Drew, W. T. London, E. D. Lustbader, J. E. Hesser, and B. S. Blumberg, Hepatitis B virus and sex ratio of offspring, Science 201: 687 (1978).
J. Drew, W. T. London, B. S. Blumberg, and S. Serjeantson, Hepatitis B virus and sex ratio on Kar Kar Island, Human Biology 54: 123 (1982).
H. A. Edmondson and P. E. Steiner, Primary carcinoma of the liver, Cancer 7: 462 (1954).
J. A. Fernandez-Pol, Iron: possible cause of the G arrest induced in NRK cells by picolinic acid, Biochem. Biophys. Res. Commun. 78: 136 (1977).
K. A. McGlynn, E. D. Lustbader, and W. T. London, Tuberculin skin test reactivity and hepatitis B e antigen status, in preparation (1984).
E. D. Lustbader, H. L. Hann, and B. S. Blumberg, Serum ferritin as a predictor of host response to hepatitis B virus infection, Science 220: 423 (1983).
H. L. Hann, A. E. Evans, I. J. Cohen, and J. E. Leitmeyer, Biologic differences between neuroblastoma stages IV-S and IV. Measurement of serum ferritin and E-rosette inhibition in 30 children, N. Engl. J. Med. 305: 425 (1981).
H. L. Hann, A. E. Evans, S. E. Siegel, H. Sather, D. Hammond, and R. Seeger, Serum ferritin levels as a guide to prognosis in patients with stage IV neuroblastoma, Proc. Am. Soc. Clin. Oncol. 2: 72 (Abstract #C-282) (1983).
G. Birgegard, The source of serumferritin during infection. Studies with concanavalin A-Sepharose absorption, Clin. Sci. 59: 385 (1980).
B. S. Blumberg, L. Melartin, R. A. Guinto, and B. Werner, Family studies of human serum isoantigen system (Australia antigen), Am. J. Human Genet. 18: 594 (1966).
R. G. Stevens and B. S. Blumberg, Hepatitis B in the Solomon Islands, in: “Health Effects of Westernization: Biomedical Survey in the Solomon Islands,” J. Rhoads, W. Howells, and J. Friedlaender, eds., Oxford University Press, in press (1984).
W. H. Crosby, Editorial: Fortification of food with carbonyl iron, Am. J. Clin. Nutr. 31: 572 (1978).
A. Trousseau, True and false chlorosis, in: “Lectures on Clinical Medicine,” Vol. 5, Lindsay and Blakiston, Philadelphia (1872).
R. G. Stevens, S. Kuvibidila, M. Kapps, J. Friedlaender, and B. S. Blumberg, Iron-binding proteins, hepatitis B virus, and mortality in the Solomon Islands, Am. J. Epidemiol. 118: 550 (1983).
A. Vierucci, M. de Martino, E. Graziani, M. E. Rossi, W. T. London, and B. S. Blumberg, A mechanism for liver cell injury in viral hepatitis: effects of hepatitis B virus on neutrophil function in vitro and in children with chronic active hepatitis, Pediatric Res. 17: 814 (1983).
D. R. Blake, N. D. Hall, P. A. Bacon, P. A. Dieppe, B. Halliwell, and J. M. C. Gutteridge, The importance of iron in rheumatoid disease, Lancet 2: 1142 (1981).
B. S. Blumberg and W. T. London, Hepatitis B virus: pathogenesis and prevention of primary cancer of the liver, Cancer 50: 2657 (1982).
B. S. Blumberg and W. T. London, Hepatitis B virus pathogenesis and prevention of primary cancer of the liver, in: “Accomplishments in Cancer Research 1981, General Motors Cancer Research Foundation,” J. G. Fortner and J. E. Rhoads, eds., J. B. Lippincott Company, Philadelphia (1983).
S. G. Franklin, I. Millman, and B. S. Blumberg, Hepatitis B surface antigen and polymerized albumin binding activity in sheep serum, Proc. Natl. Acad. Sci. USA 81: 564 (1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Blumberg, B.S. (1986). `Hepatitis B Virus, Iron and Iron-Binding Proteins. In: Szentivanyi, A., Friedman, H. (eds) Viruses, Immunity, and Immunodeficiency. University of South Florida International Biomedical Symposia Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2185-9_9
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2185-9_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9286-9
Online ISBN: 978-1-4613-2185-9
eBook Packages: Springer Book Archive