Skip to main content

Immunorestoration of Immunodeficiency by Biological Response Modifiers

  • Chapter
Viruses, Immunity, and Immunodeficiency

Abstract

It is well known that there are many mediators which are important in the generation and execution of immune responses. These mediators, when generated by lymphoid cells or when acting on lymphoid targets, have been termed lymphokines and those acting on non-lymphoid targets have been named cytokines. The combination term “lymphokine/cytokine” has been used to refer to the general class of soluble substances mediating biological responses in cell-cell interactions. These substances are distinct from, although similar to, hormones which are generally secreted by cells within the endocrine system acting on a remote target.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R. K. Oldham, Biologicals and biological response modifiers: fourth modality of cancer treatment, Cancer Treat. Rpt. 68 (1): 221 (1984).

    CAS  Google Scholar 

  2. B. H. Waksman, Overview: biology of the lymphokines, in: “Biology of Lymphokines,” eds., Academic Press (1979).

    Google Scholar 

  3. R. K. Oldham, G. N. Thurman, J. E. Talmadge, et al., Lymphokines, monoclonal antibodies and other biological response modifiers in the treatment of cancer, Cancer 1(54) (Supp. 11 ): 2795 (1984).

    Article  Google Scholar 

  4. R. K. Oldham, Biological response modifiers program, Biol. Resp. Modif. 1: 81 (1982).

    Google Scholar 

  5. I. J. Fidler, M. Berendt, and R. K. Oldham, The rationale for design of screening assays for the assessment of biological response modifiers for cancer treatment, J. Biol. Resp. Modif. 1: 15 (1982).

    Google Scholar 

  6. J. E. Talmadge, R. K. Oldham, and I. J. Fidler, Practical considerations for the establishment of a screening procedure for the assessment of biological response modifiers, J. Biol. Resp. Modif. 3: 88 (1984).

    CAS  Google Scholar 

  7. N. Flomenberg, K. Welte, R. Mertelsmann, et al., Immunologic effects of interleukin 2 in primary immunodeficiency diseases. IV. J. Immunol. 130: 2644 (1983).

    PubMed  CAS  Google Scholar 

  8. S. A. Sherwin, J. A. Knost, S. Fein, et al., A multiple dose phase I trial of recombinant leukocyte A interferon in cancer patients, JAMA 248: 2461 (1982).

    Article  PubMed  CAS  Google Scholar 

  9. S. A. Sherwin, J. A. Knost, S. Fein, et al., A multiple dose phase I trial of recombinant leukocyte A interferon in cancer patients, JAMA 248: 2461 (1982).

    Article  PubMed  CAS  Google Scholar 

  10. K. A. Foon, S. A. Sherwin, P. G. Abrams, et al., Recombinant leukocyte A interferon: an effective agent for the treatment of advanced non-Hodgkin’s lymphoma, N. Eng. J. Med. 311 (18): 1148 (1984).

    Article  CAS  Google Scholar 

  11. P. A. Bunn, Jr., K. A. Foon, D. C. Idhe, et al., Recombinant leukocyte A interferon: an active agent in advanced cutaneous T-cell lymphomas, Annals Int. Med. 101 (4): 484 (1984).

    Google Scholar 

  12. J. M. Kirkwood and M. S. Ernstoff, Interferons in the treatment of human cancer, J. Clin. Oncol. 2: 336 (1984).

    PubMed  CAS  Google Scholar 

  13. R. K. Oldham, Monoclonal antibodies in cancer therapy, J. Clin. Oncol. 1: 582 (1983).

    PubMed  CAS  Google Scholar 

  14. R. K. Oldham, K. A. Foon, A. C. Morgan, et al., Monoclonal antibody therapy of malignant melanoma: in vivo localization in cutaneous metastasis after intravenous administration, Clin. Oncol. 2 (11): 1235 (1984).

    CAS  Google Scholar 

  15. A. B. Cosimi, R. B. Colvin, R. C. Burton, et al., Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts, N. Eng. J. Med. 305: 308 (1981).

    Article  CAS  Google Scholar 

  16. K. A. Foon, R. W. Schroff, P. A. Bunn, et al., Effects of monoclonal antibody therapy in patients with chronic lymphocytic leukemia, Blood 64 (5): 1085 (1984).

    PubMed  CAS  Google Scholar 

  17. R. W. Schroff, K. A. Foon, S. B. Wilburn, et al., Human antimurine immunoglobulin responses in patients receiving monoclonal antibody therapy, Cancer Res. 45 (2): 879 (1985).

    PubMed  CAS  Google Scholar 

  18. R. A. Miller, D. G. Maloney, R. Warnke, et al., Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody, N. Eng. J. Med. 306: 517 (1982).

    Article  CAS  Google Scholar 

  19. S. L. Giardina, R. W. Schroff, C. S. Woodhouse, et al., Detection of two distinct malignant B-cell clones in a single patient using anti-idiotype monoclonal antibodies and immunoglobulin in gene rearrangement, (submitted, 1984 ).

    Google Scholar 

  20. R. K. Oldham and R. V. Smalley, Immunotherapy: the old and the new, J. Biol. Resp. Modif. 2: 1 (1983).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Oldham, R.K. (1986). Immunorestoration of Immunodeficiency by Biological Response Modifiers. In: Szentivanyi, A., Friedman, H. (eds) Viruses, Immunity, and Immunodeficiency. University of South Florida International Biomedical Symposia Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2185-9_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2185-9_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9286-9

  • Online ISBN: 978-1-4613-2185-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics