Structural Analogs of AF64A: Synthesis and their Effects on High Affinity Choline Transport and QNB Binding
A chronic deficiency in central cholinergic function has been demonstrated in a number of neuropsychiatrie diseases, including Alzheimer’s disease.1–6 Until recently, animal models that simulate the neurochemical conditions which appear to cause these diseases in humans, as a result of a direct manipulation of the central cholinergic system, were not available. Over the past few years, however, we have been successful in developing a compound, ethylcholine mustard aziridinium ion (AF64A), which has the potential to serve as a novel toxin in developing animal models of human brain disorders in which a cholinergic hypofunction has been implicated.
KeywordsDevelop Animal Model Choline Acetyl Central Cholinergic System Brain Acetylcholine Quinuclidinyl Benzilate
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