Structural Analogs of AF64A: Synthesis and their Effects on High Affinity Choline Transport and QNB Binding

  • J. S. Mistry
  • D. J. Abraham
  • I. Hanin
Part of the Advances in Behavioral Biology book series (ABBI, volume 29)

Abstract

A chronic deficiency in central cholinergic function has been demonstrated in a number of neuropsychiatrie diseases, including Alzheimer’s disease.1–6 Until recently, animal models that simulate the neurochemical conditions which appear to cause these diseases in humans, as a result of a direct manipulation of the central cholinergic system, were not available. Over the past few years, however, we have been successful in developing a compound, ethylcholine mustard aziridinium ion (AF64A), which has the potential to serve as a novel toxin in developing animal models of human brain disorders in which a cholinergic hypofunction has been implicated.

Keywords

Neurol Choline Acetylcholine Acetyl Chol 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. S. Mistry
    • 1
  • D. J. Abraham
    • 1
  • I. Hanin
    • 2
  1. 1.Depts. of Medicinal ChemistryUniversity of PittsburghPittsburghUSA
  2. 2.Dept. of Pharmacology and Experimental TherapeuticsLoyola University Stritch School of MedicineChicagoUSA

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