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AF64A Induced Cholinotoxicity: Behavioral and Biochemical Correlates

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Alzheimer’s and Parkinson’s Disease

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 29))

Abstract

The postulated involvement of the cholinergic system in Alzheimer’s disease (AD) has highlighted the research and therapeutic approach of this affliction during the last decade (1). There is little doubt at the present stage that a clear hypofunction of the cholinergic system is in evidence in certain brain areas in AD patients. Other neurotransmitter systems seem to be relatively unaffected (1).

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References

  1. Coyle, J.T., Price, D.L. and Delong, M.R. Alzheimer’s disease: A disorder of cortical cholinergic innervation. Science 219: 1184–1190 (1983).

    Article  PubMed  CAS  Google Scholar 

  2. Bartus, R.T. Physostigmine and recent memory: Effects in young and aged non human primates. Science 206: 1087–1089 (1979).

    Article  PubMed  CAS  Google Scholar 

  3. Fisher, A. and Hanin, I. Animal models for senile dementia of Alzheimer’s type with particular emphasis on AF64A-induced cholino- toxicity. Ann. Rev. Pharmacol. Toxicol. (1986).

    Google Scholar 

  4. Morris, R. Developments of a water maze procedure for studying spatial learning in the rat. J. Neurosci. Meth. 11: 47–60 (1984).

    Article  CAS  Google Scholar 

  5. Jarrard, L.E., Kant, G.J., Meyerhoff, J.C. and Levy, A. Behavioral and Neurochemical effects of intraventricular AF64A administration rats. Pharmacol. Biochem. Behav. 21: 273–280 (1984).

    Article  PubMed  CAS  Google Scholar 

  6. Fonnum, F. A rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24: 407–409 (1975).

    Article  PubMed  CAS  Google Scholar 

  7. Amir, A., Heldman, E., Pittel, Z., Fisher, A. and Schachar, A. Unpublished data.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Israel Institute for Biological Research, Ness-Ziona, 70450, Israel

    R. Brandeis, Z. Pittel, C. Lachman, E. Heldman, S. Luz, S. Dachir, A. Levy & A. Fisher

  2. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    I. Hanin

Authors
  1. R. Brandeis
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  2. Z. Pittel
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  3. C. Lachman
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  4. E. Heldman
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  5. S. Luz
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  6. S. Dachir
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  7. A. Levy
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  8. I. Hanin
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  9. A. Fisher
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Editor information

Editors and Affiliations

  1. Israel Institute for Biological Research, Ness-Ziona, Israel

    Abraham Fisher  & Chaim Lachman  & 

  2. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin

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© 1986 Plenum Press, New York

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Brandeis, R. et al. (1986). AF64A Induced Cholinotoxicity: Behavioral and Biochemical Correlates. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_53

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  • DOI: https://doi.org/10.1007/978-1-4613-2179-8_53

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9283-8

  • Online ISBN: 978-1-4613-2179-8

  • eBook Packages: Springer Book Archive

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