Abstract
In humans and animals, intact central cholinergic transmission is critical for normal learning and memory (1,6); clinical data from Alzheimer’s Disease (AD) patients indicate that dementia severity correlates with degree of cortical cholinergic deficit (24). It is likely that cortical cholinergic neurons, arising from the nucleus basal is of Meynert, mediate many cognitive functions that are impaired in AD. In the rat, neurotoxic lesions of the magnocellular basal forebrain (MNBF) cell bodies, which comprise the homologue of the human nucleus basaiis, decrease cholinergic innervation selectively in cortex and impair acquisition and retention of aversively- and appetitively-motivated behavior (8,9,14,15,17). Young rats with bilateral MNBF lesions display several important features common to AD, thus, the lesion may provide an animal model useful for studying AD.
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© 1986 Plenum Press, New York
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Lerer, B.E., Warner, J. (1986). Radial Maze Performance Deficits Following Lesions of Rat Basal Forebrain. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_49
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DOI: https://doi.org/10.1007/978-1-4613-2179-8_49
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