Hormone-Stimulated Adenylate Cyclase Activity In Man: Studies With Peripheral Models
Cyclic AMP, the so-called “second messenger” mediates the effects of a number of hormones including catecholamines on a plethora of cell processes (1). The hormone-stimulated adenylate cyclase complex consists of three principal components. The receptor spans the plasma membrane and its external side provides a site for binding circulating hormones. The Ns and Ni proteins, or guanine-nucleotide binding regulatory subunits, link the receptor to the catalytic subunit of the enzyme. Ihe activated or inhibited (in the case of Ni coupling) catalytic subunit converts ATP to cyclic AMP. The various components of the hormone-sensitive adenylate cyclase complex can to sane extent be separately measured and a number of studies have demonstrated the functional independence of these subunits (2).
KeywordsAdenylate Cyclase Adenylate Cyclase Activity Intact Lymphocyte Acute Desensitization Salbutamol Infusion
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