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Clinical, Pathological and Biochemical Aspects of Alzheimer’s Disease

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Alzheimer’s and Parkinson’s Disease

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 29))

Abstract

Clinical diagnosis of Alzheimer’s disease/senile dementia of the Alzheimer’s type (AD/SDAT) is based on progressive loss of mental faculties, often beginning with memory, learning, attention and judgment.

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References

  • Adolfsson R., Gottfries, C.G., Roos, B.E., and Winblad, B., Changes in the brain catecholamines in patients with dementia of the Alzheimer type, Br. J. Psychiat. 135: 216–223 (1979).

    Article  CAS  Google Scholar 

  • Alzheimer’s Disease, Report of the Secretary’s Task Force on Alzheimer’s Disease, U.S. Department of Health and Human Services, Publication No. (ADM) 84–1323 (1984).

    Google Scholar 

  • Ball, M.J., and Nuttall, K., Neurofibrillary tangles, granulovascuolar degeneration in the hippocampus with ageing and dementia. Acta Neuropathol. (Berl) 37: 111–118 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Bielschowski, M., Zur Kenntnis de Alzheimerischen Krankheit (prasenilenDemenz mit Herdsymptomen), J. Psychol. Neurol. 18: 273–292 (1911).

    Google Scholar 

  • Blocq, P., and Marinesco, G., Sur les lesions et la pathogenie de L’epilepsie dite essentielle, Sem. Med. 12: 445–446 (1892).

    Google Scholar 

  • Bouman, L., Senile plaques, Brain 57: 128–142 (1934).

    Article  Google Scholar 

  • Bowen, D.M., Biochemical assessment of neurotransmitter and metabolic dysfunction and cerebral atrophy in Alzheimer’s disease, Banbury Report 15: Biological Aspects of Alzheimer’s Disease, Cold Spring Harbor Laboratory, pp. 219–231 (1983).

    Google Scholar 

  • Bruce, ME., Dickinson, AG., and Fraser, H., Cerebral amyloidosis in scrapie in the mouse: Effect of agent strain and mouse genotype, Neuropathol. Appl. Neurobiol. 2:471–478 (1976). Cohen, D., Kennedy, G., and Eisdorfer, C., Phases of change in the apatient with Alzheimer’s dementia: A conceptual dimension for defining health care management. J. Amer. Geriatrics Soc. 32(1):11-15 (1984).

    Article  Google Scholar 

  • Bruce, M.E., and Fraser, H., Effect of route of inoculation on the frequency and distribution of cerebral amyloid plaques in scrapie mice, Neuropathol. Appl. Neurobiol. 7: 289–298 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Collis, S.C., Kimberlin, R.H., and Millson, G.C., Immunoglobulin G concentration in the sera of Hardwick sheep with natural scrapie, J. Comp. Pathol. 89: 389–396 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Coyle, J.T., Price, D.L., and DeLong, M.R., Brain mechanisms in Alzheimer’s disease, Hosp. Practice 17: 55–63 (1982).

    CAS  Google Scholar 

  • Crapper, DR., Dalton, AJ., Karlik, SJ., DeBoni, U., Role of aluminum in Alzheimer’s disease, in, “Electrolytes and Neuropsychiatric Disorders,” PE. Alexander, ed., S.P. Medical and Scientific Books, New York, pp. 89–111 (1981).

    Google Scholar 

  • Dahl, D., Selkoe, D.J., Pero, R.T., and Bignami, A., Immunostaining of neurofibrillary tangles in Alzheimer’s senile dementia with a neurofilament antiserum, J. Neurosci. 2: 113–119 (1982).

    PubMed  CAS  Google Scholar 

  • Davies, P., Katzman, R., and Terry, R.D., Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer’s disease and Alzheimer senile dementia, Nature 288: 279–280 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Davies, P., and Maloneyt A.J.F,, Selective loss of central cholinergic neurons in Alzheimer’s disease Lancet 2 1403 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Divry, P., De la nature de l’altération fibrillaire d’Alzheimer, J. Belge Peurol. Psychiatr. 34: 197–201 (1934).

    Google Scholar 

  • Ferraro, A., The origin and formation of senile plaques, Arch. Neurol. Psych. 25: 1042 (1931).

    Google Scholar 

  • Fisher, O., Miliare Nekrosen mit drusigen Wuckerunger der Neurofibrillen, eine regelmassige Veränderung der Hirnrinde bei senile Demenz, Monatsschr. Psychiat. Neurol. 22: 361–372 (1907).

    Article  Google Scholar 

  • Gambetti, P., Velasco, ME., Dahl, D., Bignami, A., Roessmann, U. and Sindley, SD., Alzheimer neurofibrillary tangles: An immunohistochemical study, in, “Aging of the Brain and Dementia,” L. Amaducci, AN. Davison, and P. Antuono, eds., Raven Press, New York, pp. 55–63 (1980).

    Google Scholar 

  • Ghetti, B., and Wisniewski, H.M., On degeneration of terminals in the cat striatal cortex, Brain Res. 44: 630–635 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Glenner, G ., Amyloid deposits and amyloidosis, New Eng. J. Med. 302:1283–1292; 1333-1343 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Grundke-Iqbal, I., Johnson, A.B., Wisniewski, H.M., Terry, R.D., and Iqbal,, K., Evidence that Alzheimer neurofibrillary tangles originate from neurotubules. Lancet 1: 578–580 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Iqbal, K., Grundke-Iqbal, I., Merz, P.A., and Wisniewski, H.M., Alzheimer neurofibrillary tangle: Morphology and biochemistry, Exp. Brain Res. (Suppl.) 5: 10–14 (1982).

    CAS  Google Scholar 

  • Iqbal, K., Zaidi, T., Thompson, C.H., Merz, P.A., and Wisniewski, H.M., Alzheimer paired helical filaments: Bulk isolation, solubility and protein composition, Acta Neuropathol. (Berl) 62: 167–177 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Jellinger, K ., Neuroaxonal dystrophy: Its natural history and related disorders, in, “Progress in Neuropathology,” HM. Zimmerman, ed., Grune and Stratton, New York, Vol. II, pp. 129–180 (1973).

    Google Scholar 

  • Katzman, R., Early detection of senile dementia, Hosp. Practice, 16: 61–76 (1981).

    CAS  Google Scholar 

  • Kemper, T ., Neuroanatomical and neuropathological changes in normal aging and dementia, in, “Clinical Neurology of Aging,” ML. Albert, ed., Oxford University Press, New York-Oxford, pp. 9–52 (1984).

    Google Scholar 

  • Mann, DMA., Lincoln, J., Yates, PU., Stamp,JE., and Toper, S., Changesin the monoamine containing neurons of the human CNS in senile dementia, Br. J. Psychiat. 136:533–542 (1980).

    Article  CAS  Google Scholar 

  • Marinesco, G., and Minea, J., Untersuchungen über die senilen plaques, Monatasshi f. Psych, u. Neue. 31, Eng. H. 79 (1912).

    Article  Google Scholar 

  • Metuzals, J., Montpetit, V., Clapin, D.F., and Nelson, R.F., Arrays of paired helical filaments in Alzheimer’s disease, in, “Proc. of the Electron Microscopy Socity of America,” Washington, D.C., Claitor’s Publ. Div., Baton Rouge, pp. 348–349 (1982).

    Google Scholar 

  • Moretz, RC., Wisniewski, HM., and Lossinsky, AS., Pathogenesis of neuritic and amyloid plaques in scrapie - ultrastructural study of early changes in the cortical neuropil. In “Aging of the Brain,” D. Samuel, S. Algeri, S. Gershon, VE. Grimm, and G. Toffano, eds., Raven Press, New York, pp. 61–79 (1983).

    Google Scholar 

  • Price, D.L., Whitehouse, P.J., Struble, R.G., Clark, A.W., Coy le, J.T., DeLong, M.R., and Hedreen, J.C., Basal forebrain cholinergic systems in Alzheimer–s disease and related dementias, Neurosci. Commentaries 1: 84–92 (1982).

    Google Scholar 

  • Pro, J.D., Smith, Maj. C.H., and Sumi, S.M., Presenile Alzheimer’s disease: Amyloid plaques in the cerebellum, Neurology 30: 820–825 (1980).

    PubMed  CAS  Google Scholar 

  • Probst, A., Basler, V., Bron, B., and Ulrich, J., Neuritic plaques in senile dementia of the Alzheimer type: A Golgi analysis in the hippocampal region, Brain Res. 268: 249–254 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Reisberg B ., Clinical presentation, diagnosis and symptomatology of age-associated cognitive decline and Alzheimer’s disease, in, “Alzheimer’s Disease,” B. Reisberg, ed., The Free Press, New York, pp 173–187, (1983).

    Google Scholar 

  • Ropper, A.H., and Williams, R.S., Relationship between plaques, tangles and dementia in Down syndrome, Neurology 30: 639–644 (1980).

    PubMed  CAS  Google Scholar 

  • Roth, M., Tomlinson, B.E., and Blessed, G., Correlation between scores for dementia and counts of senile plaques in cerebral gray matter of elderly subjects, Nature 206: 109–110 (1966).

    Article  Google Scholar 

  • Rudelli, R.D., Ambler, M.W., and Wisniewski, H.M., Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon, Acta Neuropathol. (Berl) 64: 273–281 (1984).

    Article  CAS  Google Scholar 

  • Schwartz, P., Amyloidosis: Cause and Manifestations of Senile Deteriorations, Charles C. Thomas, Springfield, Illinois (1970).

    Google Scholar 

  • Seitelberger, F., Neuropathological conditions related to neuroaxonal dystrophy, Acta Neuropathol. (Berl) (Suppl V), 17–29 (1971).

    Google Scholar 

  • Selkoe, D.J., Molecular pathology of the aging human brain, Trends in Neuroscience 5: 332–336 (1982).

    CAS  Google Scholar 

  • Shirahama, T., Skinner, M., Westermark, P., Rubinow, A., Cohen, A.S., Brun, A., and Kemper, T.L., Senile cerebral amyloid: Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in microangiopathic lesion, Amer. J. Pathol. 107: 41–50 (1982)

    CAS  Google Scholar 

  • Simchowicz, T., Histologische Studien über die senile demenz. Nissl-Alzheimer’s Arbeiten 4: 267–444 (1911).

    Google Scholar 

  • Sinex, F. Marrott, and Myers, R.H., Alzheimer’s disease, Down’s syndrome and aging: The genetic approach, Annals NY Acad. Sci. 396: 3–13, (1982).

    Article  CAS  Google Scholar 

  • Struble, R.G., Cork, L.C., Whitehouse, P.J., and Price, D.L., Cholinergic innervation in neuritic plaques, Science 216: 413–415 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Terry, RD., and Wisniewski, HM., The ultrastructure of the neurofibrillary tangle and the senile plaque, in, “Alzheimer’s Diseases and Related Conditions,” GE. Wolstenholme and M. O’Connor, eds., Ciba Foundation Symposium, London, Churchill, London, pp. 145–168 (1970).

    Google Scholar 

  • Tomlinson, B.E., Blessed, G., and Roth, M., Observations on the brains of demented old people. J. Neurol. Sci. 11: 205–242 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Whitehouse, P.J., Price, D.L., Clark, A.W., Coyle, J.T., and DeLong, M.R., Alzheimer’s disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis, Ann. Neurol. 10: 122–126 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Whitehouse, P.J., Price, D.L., Struble, R.G., Clark, A.W., Coyle, J.T., and DeLong, M.R., Alzheimer’s disease and senile dementia: Loss of neurons in the basal forebrain, Science 215: 1237–1239 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski, H.M., Bruce, M.E., and Fräser, H., Infectious etiology of neuritic (senile) plaques in mice, Science, 190: 1108–1110 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski, H.M., Iqbal, K., and McDermott, J.R., Aluminum-induced neurofibrillary changes: Its relationship to senile dementia of the Alzheimer’s type, Neurotoxicology 1: 121–124 (1980).

    CAS  Google Scholar 

  • Wisniewski, H.M., and Kozlowski, P.B., Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT), Ann. New York Acad. Sci. 396: 119–129 (1982).

    Article  CAS  Google Scholar 

  • Wisniewski, H.M., Lossinsky, A.S., Moretz, R.C., and Vorbrodt, A.W.,Neuritic plaque formation and blood-brain barrier (BBB) changes in scrapie, J. Neuropathol. Exp. Neurol. 40: 1342 (1981b).

    Google Scholar 

  • Wisniewski, HM., and Merz, GS., Neuropathology of the aging brain and dementia of the Alzheimer type, in, “Aging 2000: Our Health Care Destiny,” CM. Gaitz and T. Samorajski, eds., Volume I, Biomedical Issues, Springer-Verlag, New York, pp. 231–243 (1985).

    Chapter  Google Scholar 

  • Wisniewski, H.M., Merz, P.A., and Iqbal, K., Ultrastructure of paired helical filaments of Alzheimer’s neurofibrillary tangle J. Neuropath, Exp, Neurol, 43: 643–656 (1984).

    Article  CAS  Google Scholar 

  • Wisniewski, H.M., Moretz, R.C., and Lossinsky, A.S., Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent, Ann. Neurol, 10: 517–522 (1981c).

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski, H.M., Narang, H.K., and Terry. R.D.. Neurofibrillary tangles of paired helical filaments, J. Neurol. Sci. 27: 173–181 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski, H.M., Shelanski, M.L., and Terry, R.D., Effects of miotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells, J. Cell Biol. 38: 224–229 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski, HM., Sinatra, RS, Iqbal, K., and Grundke-Iqbal, I, Neurofibrillary and synaptic pathology in the aged brain, in, “Aging and Cell Structure,” JE.Johnson, Jr., ed., Vol. 1, Plenum Press, New York, pp. 104–142 (1981a).

    Google Scholar 

  • Wisniewski, H.M., Sturman, J.A., Shek J.W., and Iqbal, K., Aluminum and the central nervous system, in, “Clinical Implication of Aluminum Neurotoxicity,” L. Liss, ed., Chem-Orbital, Park Forest South, Illinois, in press.

    Google Scholar 

  • Wisniewski, HM., and Terry, RD., An experimental approach to the morphogenesis of neurofibrillary degeneration and the argyrophilic plaque, in, “Alzheimer’s Diseases and Related Conditions,” GE. Wolstenholme and M. O’Connor, eds., Ciba Foundation Symposium, London, Churchill, London, pp. 223–243 (1970).

    Google Scholar 

  • Wisniewski, H.M., and Terry, R.D., Morphology of the aging brain, human and animal, Progress in Brain Research 40: 167–186 (1973a).

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski, HM., and Terry, RD., Reexamination of the pathogenesis of the senile plaque, in “Progress in Neuropathology,” HM. Zimmerman, ed., Vol. II, Grune and Stratton, New York, pp. 1–26 (1973b).

    Google Scholar 

  • Wisniewski, H.M., Terry, R.D., and Hirano, A., Neurofibrillary pathology. J. Neuropathol. Exp. Neurol. 29: 163–176 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski, HM., Vorbrodt, AW., Moretz, RC., Lossinsky, AS., and Grundke-Iqbal, I., Pathogenesis of neuritic (senile) and amyloid plaque formation, in, “The Aging Brain - Physiological and Pathological Aspects,” S. Hoyer, ed., Experimental Brain Research Supplementum 5, Springer-Verlag, New York, pp. 3–9, (1982).

    Google Scholar 

  • Wisniewski, H.M., and Wen, G.Y., Substructures of paired helical filaments from Alzheimer’s disease neurofibrillary tangles. Acta Neuropathol. (Berl) in press.

    Google Scholar 

  • Wisniewski, K., Jervis, G.A., Moretz, R.C., and Wisniewski, H.M., Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia, Ann. Neurol. 5: 288–294 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski, K.E., Wisniewski, H.M., and Wen, G.Y., Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome, Ann. Neurol. 17: 278–282 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Wood, P.L., Etienne, P., Lai, S., Gauthier, S., Cajal, S., and Nair, N.P.V., Reduced lumbar CSF somatostatin levels in Alzheimer’s disease, Life Sci. 31: 2073–2079 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Yen, S.C., Gaskin, G., and Terry, R.D., Immunocytochemical studies of neurofibrillary tangles, Am. J. Pathol. 104: 77–89 (1981).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. New York State Office of Mental Retardation and Developmental Disabilities, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA

    Henryk M. Wisniewski

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  1. Henryk M. Wisniewski
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Editors and Affiliations

  1. Israel Institute for Biological Research, Ness-Ziona, Israel

    Abraham Fisher  & Chaim Lachman  & 

  2. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin

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© 1986 Plenum Press, New York

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Wisniewski, H.M. (1986). Clinical, Pathological and Biochemical Aspects of Alzheimer’s Disease. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_4

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  • DOI: https://doi.org/10.1007/978-1-4613-2179-8_4

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