Abstract
Previous work has documented that the common dementing diseases are associated with reductions of cerebral blood flow. Moreover, the reductions appear mostly in cortical regions, and may show sufficient regional specificity to serve as accurate diagnostic discriminators among various etiologies of dementia. We here report initial results from a study that extends these previous investigations in several directions. The present study employs a new technology for the measurement of regional Cerebral Blood Flow (rCBF). Moreover this is the first study to carefully document the severity of dementia on several dimensions, and examine rCBF abnormalities in relation to such indices of severity. Finally, all previous studies were performed on patients with severe demential of relatively long duration; we report the extension of the findings to patients at the early stages of the disease.
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© 1986 Plenum Press, New York
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Prohovnik, I., Smith, G., Sackeim, H.A., Mayeux, R., Stern, Y. (1986). The Early Stages of Presenile and Senile Alzheimer’s Disease: Initial Studies of Disease Severity and Cerebral Blood Flow. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_29
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DOI: https://doi.org/10.1007/978-1-4613-2179-8_29
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