Abstract
Normal aging, Alzheimer’s disease (AD), senile dementia of the Alzheimer type (SDAT) and Parkinson’s disease (PD) are associated with many histological, physiological and biochemical abnormalities in the CNS but few non-invasive procedures are currently available to evaluate such changes in vivo. In the brain, regional cerebral blood flow (rCBF) is coupled to local tissue metabolic rates1 and its measurement can therefore provide useful information on both cerebral hemodynamics and the metabolic-functional state2 in these disorders. We determined the resting state rCBF in a large series of normal subjects and in patients with AD,SDAT and PD using the non-invasive and atraumatic 133 Xenon inhalation technique3,4. The rCBF measurements were designed to gain more insight on several important issues i.e. the natural history of the rCBF during normal aging, the extent of rCBF reductions in patients with AD and SDAT and its relation to severity of dementia and to loss of metabolically active brain tissue, the alterations in rCBF in PD patients and their relationship to severity, duration and progression of the disease, to dopatherapy and to presence of dementia and its severity.
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© 1986 Plenum Press, New York
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Melamed, E., Globus, M., Mildworf, B. (1986). Regional Cerebral Blood Flow in Dementing Disorders. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_28
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DOI: https://doi.org/10.1007/978-1-4613-2179-8_28
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