Abstract
There are at least two different forms of intellectual impairment in patients with Parkinson’s disease (PD). Approximately 30% of patients may eventually become demented (1). This dementia is difficult to differentiate from dementia of the Alzheimer type (DAT) (2) and may be associated with similar neuropathologic and neurochemical changes (3,4). In particular, changes in the cholinergic system may be similar (5). The majority of parkinsonians, however, carry on relatively normal lives with unimpaired social and occupational functioning, and meet no recognized criteria for dementia. In these non-demented patients, careful neuropsychological testing often reveals subtle intellectual deficits, most commonly perceptual motor dysfunction (1).
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References
Mayeux R, Stern Y. Intellectual dysfunction and dementia in Parkinson’s disease. Adv Neurol 1983; 38: 211–227.
Mayeux R Stern Y, Rosen J, Benson DF. Is “subcortical dementia” a recognizable clinical entity? Ann Neurol 1983;14:278–283.
Hakim AM and Mathieson G. Dementia Parkinson’s disease: a neuro-pathologic study. Neurology 1979; 29: 1209–14.
Whitehouse P, Hedreen JCr White C, DeLong M, Price DL. Basal forebrain neurons in the dementia of Parkinson’s disease. Ann Neurol 1983; 13: 243–248.
Ruberg M, Ploska A, Javoy-Agid F, Agid Y. Muscarinic binding and choline acetyltransferase activity in parkinsonian subjects with reference to dementia. Brain Res 1982; 232: 129–33.
Winblad B, Adolfsson R, Carlsson A Gottfries (DG. Biogenic amines in brains of patients with Alzheimer’s disease. Aging 19; 1982: 25–33.
Adolfsson R, Gottfries CG, Roos BE, Winblad B: Changes in brain catecholamines in patients with dementia of Alzheimer types. Brit J. Psvchiat. 1979; 135: 216–23.
Ajuriaguerra J. de, Tissot R. Some aspects of psycho-neurologic disintegration in senile dementia. In: Muller C, Ciompi L (eds.) Senile Dementia. Huber, Switzerland, pp. 69–79.
Joubert M and Barbeau A. Akinesia in parkinson’s disease. In: Barbeau A. and Brunette J-R (eds.) Progress in Neurogenetics. Excerpta Medica, Amsterdam, 1969, pp. 366–376.
Botez MI, Barbeau A. Neuropsychological findings in Parkinson’s disease: A comparison between various tests during long-term levodqpa therapy. Int J Neurol 1975; 10: 222–32.
Stern Y, Mayeux R, Rosen X Ilson J. Perceptual motor dysfunction in Parkinson’s disease: A deficit in sequential and predictive movement. J Neurol Neurosurg Psychiatry 1983; 46: 145–51.
Stern Y, Mayeux R, Rosen J. Contribution of perceptual motor dysfunction and tracing disturbances in Parkinson’s disease. J Neurol Neurosurg Psychiatry 1984; 47: 983–94.
Flowers K. Lack of prediction in the motor behavior of parkinsonism. Brain 1978; 101: 35–52.
Pirozzolo FJ, Hansach EC, Mortimer JA, WëDSter DD and Kuskowski MA. Dementia in Parkinson’s disease: A neuropsychological analysis. Brain cognition 1982; 1: 71–83.
Mayeux R, Tomaino C, Rosen J, Stern Y, Gerstman L. The effects of parkinsonism and aging on tactile-niotor skills and perception. Neurology (Abstract), 1983; 33: 198A.
Marsden CD: The mysterious irotor function of the basal ganglia: The Robert Wartöiberg Lecture. Neurology 1982; 32: 514–39.
Stern Y. Behavior and the basal ganglia. Adv Neurol 1983; 38: 195–210.
Bowen FP. Behavioral alterations in patients with basal ganglia lesions. In Yahr MD (ed.) The Basal Ganglia. Raven Press, 1975, pp. 169–80.
Lee AJ, Smith E, Cognitive deficits in the early stages of Parkinsons disease. Brain 1983; 106: 257–70.
Lezack M: Neuropsychological assessneit. Oxford Press, New York, 1976, pp. 208–211.
Divac I. Nfeostriatum and functions of the prefrontal cortex. Acta Neurobiol Exp 1972; 32: 461–77.
Brozoski TJ, Brown RM, Rosvold HE, Goldman PS. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 1979; 205: 929–32.
Längsten JW, Ballard P, Tefrud JW, Irwin I. Chronic parkinsonism in humans due to a product of mepedrine analogue synthesis. Science 1983; 219: 979–80.
Langstai JW, Ballard P. Parkinsonism induced by l-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP): Implications for treatment arK3 the pathogenesis of Parkinson’s disease. Can J Neurol Sci 1984; 11: 160–5.
Bums RS, Chiveh CC, Markey SP, Ebert MM, Jacobowitz DM, Kopin IJ. A primate model of parkinsonism: Selective destruction of neurons in the pars compacta of the substantia ni gra by N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine. Proc Natl Acad Sci. USA, 1983; 80: 4546–50.
Langstai JW, Fomo LS, Robert CS, Irwin I. Selective nigral toxicity after systematic administration of l-inethyl-4-phenyl- 1,2,5,6-tetrahydropyridine (MPTP) in the squirrel monkey. Brain Res. 1984; 292: 390–4.
Davis GC, Williams AC, Markey SP, Ebert MH, Caine ED, Reichert CM, Kopin IJ. Chronic parkinsonism seccxidary to intravenous injection of mg)edrine analogues. Psychiatry Res. 1979; 1: 249–54.
Ballard PA, Längsten JW, Tetrud J. Bums Rs. Chemically induced chronic parkinsonism in young adults: Qinical and neuro- pharmacologic aspects. Neurology (Abstract) 1983; 33: 90A
Stern Y, Langston JW. Intellectual changes in patients with MPTP-induced parkinsonism. Neurology in press.
Matison R, Mayeux R, Rosen J, Fahn S. “Tip-of-the-tongue” phenomenon in Parkinson’s disease. Neurology 1982; 32: 567–70.
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© 1986 Plenum Press, New York
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Stern, Y., Mayeux, R. (1986). Possible Dopaminergic Basis for Perceptual Motor Dysfunction. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_24
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DOI: https://doi.org/10.1007/978-1-4613-2179-8_24
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