Increased Vasopressin Production in Senescence and Dementia Due to Kidney Changes
Vasopressin (VP) is involved as a neurotransmitter in a number of central functions that are frequently disturbed during aging and dementia. Therefore, this peptide has been used in clinical trials as a ‘substitution therapy’ for the degenerating peptidergic neurons, aimed at improving cognitive functions in aged and demented individuals with unequivocal results. In order to investigate whether the VP systems indeed show the claimed degenerative changes during aging and dementia, we focused in the first place on the Supra Optic Nucleus (SON) and the Para Ventricular Nucleus (PVN). VP cells were identified by means of immunocytochemistry in a series of 32 formalin-fixed human hypothalami, including k patients with senile dementia of the Alzheimer type (SDAT). in the SON and PVN, VP cell and nucleolar size was determined by means of a digitizer device, as parameter for peptide synthesizing activity. VP cell size and nucleolar size increased beyond 80 years of age, both in the PVN and in the SON. In SDAT patients these measures fell within the range for their age group. Instead of degenerative changes, these results show an activation of the vasopressinergic system, in senescence and in SDAT patients, similar to earlier observations in the aged rat and in accordance with a rise in human neurophysin and VP levels reported recently. The cause for these changes might be in the kidney.
KeywordsDementia Arginine Neurol Tral Vasopressin
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- Beck, N. and Yu, BP., 1982, Effect of aging on urinary concentrating mechanism and vasopressin-dependent cAMP in rats, Am. J. Physiol., 243: Fl21-Fl25.Google Scholar
- Bengele, H.H., Mathias, R.S., Perkins, J.H. and Alexander, E.A., 1981, Urinary concentrating defect in the aged rat, Am. J. Physiol., 240: FH7–F150.Google Scholar
- De Wied, D., 1983, Central actions of neurohypophyseal hormones. In:The Neurohypophysis: Structure, Function and Control, Progress in Brain Research, Vol. 60, B.A. Cross and G. Leng, Eds., Elsevier, Amsterdam.Google Scholar
- Kirkland, J., Lye, M., Goddard, C., Vargas, E. and Davies, I., 1984, Arginine vasopressin in dehydrated elderly patients. Clin. Endocrinol., 20: 451–56,Google Scholar
- Legros, JJ., Gilot, P., Schmitz, S., Bruwier, M., Mantanus, H., and Timsit-Berthier, M., 1980, Neurohypophyseal peptides and cognitive function: a clinical approach, In_: Progress in Psychoneuroendocr inology, Brambilla, F., Racagni, G. and De Wied, D., Eds., Elsevier/North Holland Biomedical Press, 325–337.Google Scholar
- Ravid, R., Swaab, D.F. and Pool, Chr.W., 1985, Immunocytochemical localization of vasopressin binding sites in the rat kidney. J. Endoerinol., in press.Google Scholar
- Swaab, D.F., 1982, Neuropeptides. Their distribution and function in the brain. J_nj Chemical Transmission in the Brain. Progress in Brain Research, Vol. 55, Buijs, R.M., Pevet, P., and Swaab, D.F., Eds., Elsevier, Amsterdam, 97–122.Google Scholar
- Swaab, D.F., Fliers, E. and Fisser, B., 1984, The vasopressin containing neuron in the human brain. Changes during aging and senile dementia. Proc. EURAGE Workshop ‘Aging of the Brain and Senile Dementia: The Inventory of EEC Potentialities’, D.L. Knook et al. Eds., Eurage, 71–78.Google Scholar
- Swaab, D.F ., Fliers, E. and Partiman, T.S., 1985a, The suprachiasmatic nucleus of the human brain in relation to sex, age and dementia, Brain Research, in press.Google Scholar
- Swaab, D.F., Fliers, E. and Ravid, R., 1985b, The vasopressin neuron in the aging humand and rat brain. In: Proceedings of the conference: ‘Comparative Aspects of Opioid and Related Neuropeptides’, Sunny, U.S.A., in press.Google Scholar
- Swaab, D.F., Fliers, E. and Van Gool, W.A., 1985c, Immunocytochemical localization of neuropeptides in the human brain; its consequences for therapeutic strategies in aging and dementia. In: Progress in Brain Research, in press.Google Scholar