Abstract
It is of importance to determine how porphyrins are transported in blood, for two main reasons: (i) porphyrins are used for fluorescence detection and photodynamic therapy of tumors, and (ii) certain diseases such as the porphyrias and disorders such as lead intoxiation lead to an increased level of porphyrins in the blood. Until recently, albumin was thought to be the main porphyrin binding protein in serum. However, since most porphyrins are cleared through the liver, and since albumin is not taken up by hepatocytes, it has bejn conjectured that other porphyrin-binding elements exist in serum1. Attention has been drawn to hemopexin, a protein known to carry heme into hepatocytes, and to lipoproteins. Already in 1956, it was shown that porphyrin have a marked affinity for tissues with a high lipoprotein content 2.
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© 1985 Plenum Press, New York
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Moan, J., Rimington, C., Evensen, J.F., Western, A. (1985). Binding of Porphyrins to Serum Proteins. In: Kessel, D. (eds) Methods in Porphyrin Photosensitization. Advances in Experimental Medicine and Biology, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2165-1_22
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DOI: https://doi.org/10.1007/978-1-4613-2165-1_22
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