The Biological Effects of Photodynamic Therapy on Normal Skin in Mice-I. A Light Microscopic Study
Photodynamic therapy (PDT) of cancer using hematoporphyrin derivative (HpD) and visible light irradiation has been applied in clinical practice for several years and data on photobiology and photomedicine have been accumulated (1–3). Even so, much remains to be learned about the destructive mechanism of PDT. In order to better understand whether PDT may cause damaging effects to normal tissue in vivo, and the possible mechanism of its action, we have made a light and electron microscopic study on the effects of photodynamic treatment to normal mouse ears. In this paper we describe the results of our light microscopic observation and make a brief discussion on the significance of our findings.
KeywordsPhotodynamic Therapy Visible Light Irradiation Light Dose Light Microscopic Observation Light Microscopic Study
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