Abstract
Hematoporphyrin derivative (HPD) photodynamic therapy (PDT) has proved effective in the treatment of selected neoplasms (1). The effectiveness of this form of therapy rests on the retention of the systemically administered HPD in neoplastic tissue and its photoactivation with visible light resulting in ‘photodynamic’ tumor destruction. Although it is generally agreed that singlet oxygen liberated during HPD-photodynamic therapy is responsible for the biologic damage created by PDT, the mechanisms of cell death have not been clearly defined (2). Previous studies in our laboratory have demonstrated a rapid and sustained decrease in tumor blood flow after HPD-photodynamic therapy (3,4). The present study was undertaken to correlate changes in tumor blood flow with tumor regression after HPD-PDT.
Supported by grants from the American Cancer Society, B.R.S.S0-7-RR05700-12-13. the F.M. Douglas Foundation, the Geiger Foundation for Cancer Research and the NIH R23CA38754-01. Permission for reproduction of portions of this manuscript has been granted by the Journal of Urology, Williams & Wilkins Co., Baltimore MD.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Dahlrnan, A., Wile, A.G., Burns, R.G., Mason, G.R., Johnson, F.M. and Berns, M.W., Laser Photoradiation Therapy of Cancer, Cancer Res., 43: 430–484, (1983).
Weishaupt, K.R., Gomer, C.J., and Dougherty, T.J., Identification of Singlet Oxygen as the Cytotoxic Agent in Photo-inactivation of a Murine Tumor, Cancer Res. 36: 2326–2329, (1976).
Selman, S.H., Keck, R.W., Klaunig, J.E., Kreimer-Birnbaum, M., Goldblatt, P.J. and Britton, S.L., Acute Blood Flow Changes in Transplantable FANFT-Induced Urothelial Tumors Treated with Hematoporphyrin Derivative and Light, Surg. Forum, 34: 676–678, (1983).
Selman, S.H., Kreimer-Birnbaum, M., Klaunig, J.E., Goldblatt, P.J., Keck, R.W., and Britton, S.L., Blood Flow in Transplantable Bladder Tumors Treated with Hematoporphyrin Derivative and Light, Cancer Res., 44: 1924–1927, (1984).
Malik, A.B., Kaplan, J.E., and Saba, T.M., Reference Sample Method for Cardiac Output and Regional Blood Flow Determination in the Rat, J. Appl. Physiol., 40: 472–475, (1976).
Berns, M.W., Dahlman, A., Johnson, F.M., Burns, R., Sperling, D., Guiltinan, M., Siemens, A., Walter, R., Wright, W., Hammer-Wilson, M., and Wile, A., In Vitro Cellular Effects of Hemato- Porphyrin Derivative, Cancer Res. 42:2325–2329, (1982)
Moan, J., Johannsen, J.V., Christensen, T., Espevik, T., and McGhie, J.B., Porphyrin Sensitized Photoinactivation of Human Cells in Vitro., Am. J. Pathol., 109: 184–192, (1982).
Kessel, D., Effects of Photoactivated Porphyrins at the Cell Surface of Leukemia L1210 Cells, Biochemistry, 16: 3433–3449, (1977).
Moan, J., and Christensen, T., Photodynamic Effects on Human Cells Exposed to Light in the Presence of Hematoporphyrin. Localization of the Action Dye, Cancer Letters, 11: 209–214, (1981).
Blazek, E.R., and Hariharan, P.V., Alkaline Elution Studies of Hematoporphyrin Derivative Photosensitized DNA Damage and Repair in Chinese Hamster Ovary Cells, Photochemistry and Photobiology, 40: 5–13, (1984).
Castellani, A., Pace, G.P., and Concioli, M., Photodynamic Effect of Hematoporphyrin on Blood Microcirculation, J. Pathol. Bacteriol., 86: 99–102, (1963).
Bugelski, P.J., Porter, C.W., and Dougherty, T.J., Autoradiographic Distribution of Hematoporphyrin Derivative in Normal and Tumor Tissue of the Mouse, Cancer Res., 41: 4606–4612, (1981).
Bicker, H.I., Impact of Microcirculation and Physiologic Considerations on Clinical Hyperthermia, vn.: “13th International Cancer Congress, Part D,” Research and Treatment, Alan R. Liss, Inc., (1983), 235–245.
Star, W.M., Marijinissen, J.P.A., Vanden Berg-Blok, A., and Reinhold, H.S., Destructive Effect of Photoradiation on the Microcirculation of a Rat Mammary Tumor Growing in “Sandwich” Observation Chambers, in: “Porphyrin Localization and Treatment of Tumors,” 157 Do iron and C.J. Gomer, Alan R. Liss, Inc., New York, (1984), 637–645.
Henderson, B.W., Dougherty, T.J., and Malone, P.B., Studies on the Mechanism of Tumor Distruction by Photoradiation Therapy, in: “Porphyrin Localization and Treatment of Tumors,” D. Dorion and C.J. Gomer eds., Alan R. Liss, Inc., New York, (1982), 601–612.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Selman, S.H., Kreimer-Birnbaum, M., Keck, R.W., Milligan, A.J., Goldblatt, P.J., Britton, S. (1985). Correlation Of Tumor Blood Flow To Tumor Regression After Hematoporphyrin Derivative (HPD) Photodynamic Therapy To Transplantable Bladder Tumors. In: Kessel, D. (eds) Methods in Porphyrin Photosensitization. Advances in Experimental Medicine and Biology, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2165-1_11
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2165-1_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9276-0
Online ISBN: 978-1-4613-2165-1
eBook Packages: Springer Book Archive