Chemical Neurotoxins Accelerating Axonal Transport of Neurofilaments

  • Pierluigi Gambetti
  • Salvatore Monaco
  • Lucila Autilio-Gambetti
  • Lawrence M. Sayre


It has been known for years that chemical neurotoxins produce alterations of axonal morphology similar to those in some human diseases. Recently, it has been discovered that several of these agents have a specific effect on slow axonal transport and on the organization of the axonal cytoskeleton (Sayre et al., 1985). Therefore, they have become valuable probes for investigating functional and structural aspects of the normal axon as well as the pathogenesis of axonal lesions.


Superior Colliculus Axonal Transport Intermediate Filament Neurotoxic Agent Giant Axonal Neuropathy 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Pierluigi Gambetti
    • 1
    • 2
  • Salvatore Monaco
    • 1
  • Lucila Autilio-Gambetti
    • 1
  • Lawrence M. Sayre
    • 3
  1. 1.Division of NeuropathologyCase Western Reserve University School of MedicineClevelandUSA
  2. 2.Institute of PathologyCase Western Reserve University School of MedicineClevelandUSA
  3. 3.Department of ChemistryCase Western Reserve University School of MedicineClevelandUSA

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