Primary and Secondary Changes in Axonal Transport in Neurofibrillary Disorders

  • Bruce G. Gold
  • John W. Griffin
  • Donald L. Price
  • Paul N. Hoffman


Neurofibrillary changes are pathological hallmarks of a variety of neurotoxic and degenerative disorders. Progress during the last five years in reconstructing the pathogenesis of neurofibrillary changes has resulted from correlations of ultrastructural findings with aberrations in the axonal transport of neurofilament proteins. The first neurotoxic agent studied in this fashion was β,β’-iminodipropionitrile (IDPN) (Griffin et al., 1978). Recently, comparable studies have become available on aluminum (Troncoso et al., 1983; Bizzi et al., 1984; Parhad et al., 1984), colchicine (Komiya and Kurokawa, 1980), 3,4-dimethyl-2,5-hexanedione (DMHD) (Griffin et al., 1984), acrylamide (Sidenius and Jakobsen, 1983; Gold et al., 1985), and 2,5- hexanedione (Gold, Griffin, Price, unpublished observation).


Dorsal Root Ganglion Axonal Transport Ventral Root Axonal Swelling Slow Transport 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Bruce G. Gold
    • 1
  • John W. Griffin
    • 2
  • Donald L. Price
    • 3
  • Paul N. Hoffman
    • 4
  1. 1.Department of Environmental Health SciencesThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Departments of Neurology and NeuroscienceThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Departments of Pathology, Neurology and NeuroscienceThe Johns Hopkins University School of MedicineBaltimoreUSA
  4. 4.Department of OphthalmologyThe Johns Hopkins University School of MedicineBaltimoreUSA

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