Advertisement

The Cytoskeleton as a Target For Toxic Agents

  • Tore L. M. Syversen
  • Polly R. Sager
  • Thomas W. Clarkson
  • John B. Cavanagh
  • Anljot Elgsaeter
  • Hans Cato Guldberg
  • Si Duk Lee
  • Marshall A. Lichtman
  • N. Karle Mottet
  • Joanna B. Olmsted

Abstract

In the previous chapter several examples of toxic compounds that have been used as tools to elucidate the structure and function of the cytoskeleton have been described. These examples were presented in the context of cytoskeletal composition and function. In this chapter, we discuss toxic agents that have been used as tools and present a summary of such compounds. Finally, we review a number of compounds for which evidence strongly suggests that the primary effects involve the cytoskeleton.

Keywords

Axonal Transport Toxic Agent Carbon Disulfide Vinca Alkaloid Asbestos Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

Toxic Agents for Studying the Cytoskeleton

  1. Ben-Ze’ev, A., Farmer S. R. and Penman S. (1979) Mechanisms regulating tubulin synthesis in cultured mammalian cells, Cell 17: 319–325.CrossRefGoogle Scholar
  2. Bernard, C. (1875) la Science Experimentale, p. 237, Bailliere, Paris.Google Scholar
  3. Cleveland, D. W., Lopata, M. A., Sherline, P. and Kirschner, M. W. (1981) Unpolymerized tubulin modulates the level of tubulin mRNAs, Cell 25: 537–546.CrossRefGoogle Scholar
  4. Yamanda, K. M. Spooner, B. S. and Wessells, N. K. (1970) Axon Growth: roles of microtubulin and microfilaments, Proc. Natl. Acad. Sci. 66: 1206–1212.Google Scholar

Toxic Chemicals Acting on the Cytoskeleton

  1. Aldridge, W. N., (1981), Mechanisims of toxicity. New concepts are required in toxicology, Trends Pharmacol. Sci. 2: 228–231.Google Scholar

The Neuronal Cytoskeleton Agents Affecting Neuronal Microtubules

  1. Roderiguez Echandia, E. L., Ramirez, B. U. and Fernandez, H. L. (1973) Studies on the mechanism of inhibition of axoplasmic transport of neuronal organelles, J. Neurocytol. 2: 149–156.CrossRefGoogle Scholar
  2. Schlaepfer, W. W. (1971) Vincristine induced axonal alterations in rat peripheral nerve, J. Neuropathol. Exper. Neurol. 30: 488–505.Google Scholar
  3. Shelanski, M. L. and Wisniewski, H. (1969) Neurofibrillary degeneration induced by vincrestine neuropathy, Arch. Neurol. 20: 199–206.Google Scholar
  4. Watkins, S. M. and Griffin, J. P. (1978) High incidence of vincristine induced neuropathy in lymphomas, Brit. Med. J. 1: 610–612.Google Scholar

Agents Producing Neurofibrillary Pathology

  1. Gajdusek, D. C. (1985) Hypothesis: interference with axonal transport of neurofilament as a common pathogenic mechanism in certain diseases of the central nervous system, N. Eng. J. Med. 312: 714–719.Google Scholar

Aluminum

  1. Wisniewski, H. M., Sturman, J. A. and Shek, J. W. (1980) Aluminium chloride induced neurofibrillary changes induced in the developing rabbit: a chronic animal model, Ann. Neurol. 8: 479–490.Google Scholar

IDPN

  1. Clark, A. W., Griffin, J. W. and Price D. L. (1980) The axonal poathology in chronic IDPN intoxication, J. Neuropathol. Exper. Neurol. 39: 42–55.Google Scholar
  2. Hoffman, P. N., Clark, L. C., Carroll, P. T. and Price D. L. (1978) Slow axonal transport of neurofilament proteins: impairment by β, β’-iminodipropionitrile administration, Science 202: 633–635.CrossRefGoogle Scholar
  3. Pestronk, A., Keoyh, J. P. and Griffin, J. W. (1980) Dimethylaminopropronitrile, in:”Experimental and Clinical Neurotoxicology,” P. S. Spencer and H. H. Schvamburg, eds., pp 422–429, Williams and Wilkins, Baltimore.Google Scholar

β-Diketone (Hexacarbon) Compounds

  1. Cavanagh, J. B. (1982) The pattern of recovery of axons following 2,5 hexanediol intoxication: a question of rheology, Neuropathol. Neuropiol. 8: 19–34.Google Scholar
  2. Spencer, P. S., Schaumburg, H. H., Sabri, N. I. and Veronesia, B. (1980) The changing view of hexacarbon neuropathy, CRC Crit. Toxicol. 7: 279–356.Google Scholar

Carbon Disulfide

  1. Szendzikowski, S., Stetkiewicz, J. Wronska-Nofer, T. and Zdrajkowska, I. (1973) Structural aspects of experimental carbon disulphide neuropathy. I. Development of neurohistological changes in chronically intoxicated rats, Internat. Arch. Arbeitsmed. 31: 135–149.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Tore L. M. Syversen
    • 1
  • Polly R. Sager
    • 2
  • Thomas W. Clarkson
    • 3
  • John B. Cavanagh
    • 4
  • Anljot Elgsaeter
    • 1
  • Hans Cato Guldberg
    • 1
  • Si Duk Lee
    • 5
  • Marshall A. Lichtman
    • 3
  • N. Karle Mottet
    • 6
  • Joanna B. Olmsted
    • 3
  1. 1.University of TrondheimNorway
  2. 2.University of ConnecticutFarmingtonUSA
  3. 3.University of RochesterRochesterUSA
  4. 4.Institute of NeurologyLondonUK
  5. 5.EPA, Research Triangle ParkUSA
  6. 6.University of WashingtonSeattleUSA

Personalised recommendations