Two decades ago many scientists regarded the cell cytoplasm as an ill-defined sol or gel containing a few organelles. Biochemists distinguished structural proteins and enzymes but without specification of the former. Beginning in the late 1960s more detailed features of the cytoskeleton began to be defined. This body of knowledge has grown rapidly so that now not only are the principal structural protein components of microfilaments, intermediate filaments and microtubules well defined but also many of the modulating proteins are known as reviewed in Chapter 1 of this volume. This conference has focused on the role of the cytoskeleton as a target for toxic agents and in this summary I have tried to condense and highlight the important and most interesting features of individual reports.
KeywordsIntermediate Filament Erythrocyte Membrane Axonal Transport Toxic Agent Vinca Alkaloid
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