Receptor Cycling in Pituitary Cells: Biological Consequences of Inhibition of Receptor-Mediated Endocytosis

  • Patricia M. Hinkle
  • Jane Halpern
  • Patricia A. Kinsella
  • Risa A. Freedman


The anterior pituitary gland of mammalian species secretes six major trophic hormones: adrenocorticotropic hormone, two gonadotropins, thyrotrophin, prolactin and growth hormone. Synthesis and secretion of these pituitary hormones is regulated in part by hypothalamic factors which reach the pituitary gland by a portal system and which act upon specific target cells to stimulate or inhibit hormone production. In addition, pituitary function is regulated by circulating hormones including steroids and peptides.


Epidermal Growth Factor Pituitary Cell Wheat Germ Agglutinin Prolactin Secretion Epidermal Growth Factor Binding 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Patricia M. Hinkle
    • 1
  • Jane Halpern
    • 1
  • Patricia A. Kinsella
    • 1
  • Risa A. Freedman
    • 1
  1. 1.Department of Pharmacology and the Cancer CenterUniversity of Rochester, School of Medicine and DentistryRochesterUSA

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