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Receptor Cycling in Pituitary Cells: Biological Consequences of Inhibition of Receptor-Mediated Endocytosis

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The Cytoskeleton

Abstract

The anterior pituitary gland of mammalian species secretes six major trophic hormones: adrenocorticotropic hormone, two gonadotropins, thyrotrophin, prolactin and growth hormone. Synthesis and secretion of these pituitary hormones is regulated in part by hypothalamic factors which reach the pituitary gland by a portal system and which act upon specific target cells to stimulate or inhibit hormone production. In addition, pituitary function is regulated by circulating hormones including steroids and peptides.

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References

  • Aizawa, T. and Hinkle, P.M., 1985, TRH rapidly stimulates a biphasic secretion of PRL and GH in GH4C1 rat pituitary tumor cells, Endocrinology, 116: 73–8.

    CAS  Google Scholar 

  • Goldstein, J.L., Anderson, R.G.W. and Brown, M.S., 1979, Coated pits, coated vesicles, and receptor-mediated endocytosis, Nature, 279: 679–68.

    CAS  Google Scholar 

  • Gourdji, D., Tougard, C. and Tixier-Yidal, A., 1981, Clonal prolactin stains as a tool in neuroendocrinology, in: “Frontiers in Neuroendocrinology,” vol. 7, W.F. Ganong and L. Martini, eds., pp. 317–35, Raven Press, New York.

    Google Scholar 

  • Haigler, H.T., Maxfield, F.R., Willingham, M.C. and Pastan, I.H., 1980, Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells, J Biol. Chem., 255:1239–124.

    Google Scholar 

  • Hal pern, J. and Hinkle, P.M., 1981, Direct visualization of receptors for thyrotropin-releasing hormone with a fluorescein labeled analog, Proc. Natl. Acad. Sci., 78:587–59.

    Google Scholar 

  • Hal pern, J. and Hinkle, P.M., 1983, Binding and internalization of epidermal growth factor by rat pituitary tumor cells, Mol. Cell Endocrinol., 33:183–19.

    Google Scholar 

  • Hinkle, P.M., 1984, Interaction of peptide hormones with rat pituitary tumor cells in culture, in: “Secretory Tumors of the Pituitary Gland,” P. Mcl. Black, N.T. Zervos, E.C. Ridgway and J.B. Martin, eds., pp. 25–4, Raven Press, New York.

    Google Scholar 

  • Hinkle, P.M. and Kinsella, P.A., 1982, Rapid temperature dependent transformation of the thyrotropin-releasing hormone receptor complex in rat pituitary tumor cells, J. Biol. Chem., 257:5462–547.

    Google Scholar 

  • Hinkle, P.M. and Tashjian, A.H., Jr., 1973, Receptors for thyrotropin releasing hormone in prolactin producing rat pituitary cells in culture, J. Biol. Chem, 148:6180–618.

    Google Scholar 

  • Hinkle, P.M. and Tashjian, A.H., Jr., 1975a, Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture, Biochem., 14: 3845–385.

    Google Scholar 

  • Hinkle, P.M. and Tashjian, A.H., Jr., 1975b, Degradation of thyrotropin-releasing hormone by the GH3 strain of pituitary cells in culture, Endocrinology, 97: 324–33.

    CAS  Google Scholar 

  • Kaplan, J., 1981, Polypeptide-binding membrane receptors: analysis and classification, Science, 212: 14–2.

    Article  CAS  Google Scholar 

  • King, A.C. and Cuatrecasas, P., 1981, Peptide hormone induced receptor mobility, aggregation and internalization, New Engl. J. Med., 305:77–8.

    Google Scholar 

  • Pastan, I.H. and Willingham, M.C., 1981, Receptor-mediated endocytosis of hormones in cultured cells, Ann. Rev. Physiol., 43:239–25.

    Google Scholar 

  • Presky, D.H. and Schonbrunn, A., 1983, Receptor-bound somatostatin (SRIF) and epidermal growth factor (EGF) are processed differently by GH4C1 pituitary cells. Program of the 65th Annual Meeting of the Endocrine Society, A 564, p. 221.

    Google Scholar 

  • Seglen, P.O, 1983, Inhibitors of lysosomal function, Methods Enzymol., 96: 737–76.

    CAS  Google Scholar 

  • Tashjian, A.H., Jr., 1979, Clonal strains of hormone-producing pituitary cells. Methods Enzymol., 58: 527–53.

    Google Scholar 

  • Tashjian, A.H., Jr., Yasumura, Y., Sato, G.H, Parker, M.L., 1968, Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone, Endocrinology, 82: 342–35.

    CAS  Google Scholar 

  • Tixier-Vidal, A. and Gourdji, D., 1981, Mechanism of action of synthetic hypothalamic peptides on anterior pituitary cells, Physiol. Rev., 61:974–101.

    Google Scholar 

  • Webb, J.L., 1966, “Enzyme and Metabolic Inhibitors,” Chapter 6, pp. 595–64, Academic Press, New York.

    Google Scholar 

  • Westendorf, J.M. and Schonbrunn, A., 1983, Characterization of bombesin receptors in a rat pituitary cell line, J. Biol. Chem., 258:7527–753.

    Google Scholar 

  • Willingham, M.C. and Pastan, I., 1980, The receptosome: an intermediate organelle of receptor-mediated endocytosis in cultured fibroblasts, Cell, 21: 67–7.

    CAS  Google Scholar 

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© 1986 Plenum Press, New York

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Hinkle, P.M., Halpern, J., Kinsella, P.A., Freedman, R.A. (1986). Receptor Cycling in Pituitary Cells: Biological Consequences of Inhibition of Receptor-Mediated Endocytosis. In: Clarkson, T.W., Sager, P.R., Syversen, T.L.M. (eds) The Cytoskeleton. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2161-3_18

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  • DOI: https://doi.org/10.1007/978-1-4613-2161-3_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9274-6

  • Online ISBN: 978-1-4613-2161-3

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