Effects of Local Anesthetics and pH Change on the Platelet “Cytoskeleton” and on Platelet Activation

  • Vivianne T. Nachmias
  • Robert M. Leven


While platelets may at first appear to be very specialized fragments of cytoplasm, their cytoskeletons share many properties with that of more typical cells. We shall use the term cytoskeleton to mean the Triton-X 100 insoluble residue, obtained under defined conditions, which, when used on platelets attached to a surface, retains the shape of the cell. Most cells are in various states of activity. Since platelets circulate in a resting state, from which they are readily activated, they offer advantages for the study of factors that alter the state of the cytoskeleton. Also, since platelets lack intermediate filaments, properties of the cytoskeletal system that are observed in platelets cannot depend on the presence of the 10 nm filament system.


Shape Change Weak Acid Human Platelet Insoluble Residue Platelet Lysate 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Vivianne T. Nachmias
    • 1
  • Robert M. Leven
    • 2
  1. 1.Department of Anatomy School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Specialized Center for Thrombosis ResearchTemple UniversityPhiladelphiaUSA

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