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The Effect of Some Dithiocarbamates, Disulfiram and 2,5-Hexanedione on the Cytoskeleton of Neuronal Cells inVivo and inVitro

  • Veli-Pekka Lehto
  • Ismo Virtanen
  • Kai Savolainen

Abstract

Dithiocarbamates are widely used fungicides because of their low toxicity to mammalian species and because of their rather rapid biodégradation in the soil and by plants. Their fungicidal action is based on interference with the citric acid cycle of several fungi (Schlagbauer and Schlagbauer, 1972). Several dithiocarbamates show neurotoxic effects in central and peripheral nervous system (Seppalainen and Linnoila, 1976; Freudenthal et al., 1977; Chernoff et al., 1979), but the mechanisms of the neurotoxicity of dithiocarbamates are largely unexplained.

Keywords

Sciatic Nerve Intermediate Filament Carbon Disulfide Original Magnification Carbonyl Sulfide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Veli-Pekka Lehto
    • 1
  • Ismo Virtanen
    • 1
  • Kai Savolainen
    • 2
  1. 1.Department of PathologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Department of Environmental Hygiene and ToxicologyNational Public Health InstituteKuopioFinland

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