Hormone Assays in Endocrine System

  • Robert N. Alsever


A quarter of a century ago, the hormonal milieu surrounding our body systems was relatively simple and based on intuition and some selected bioassayable end points. With the development of improved radioimmunoassay (RIA) techniques, our knowledge and understanding of the endocrine system have mushroomed at an exponential rate, making it nearly impossible for physicians to keep pace with it. This chapter emphasizes hormonal assays and discusses their meaning as they might relate to gynecologic endocrinology.


Growth Hormone Luteinizing Hormone Thyroid Stimulate Hormone Luteinizing Hormone Release Hormone Adrenal Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Alsever RN, Gotlin RW: Handbook of Endocrine Tests in Adults and Children 2nd ed. Chicago, Yearbook Medical, 19781Google Scholar
  2. 2.
    Nasr H: Endocrine disorders in the elderly. Med Clin North Am 67: 481, 1983PubMedGoogle Scholar
  3. 3.
    Yalow R: Radioimmunoassay. Science 200: 1236, 1978PubMedCrossRefGoogle Scholar
  4. 4.
    Odell WD, Franchimont P: Principles of Competitive Protein-Binding Assays. New York, Wiley, 1983Google Scholar
  5. 5.
    Greenwood FC, Landon J, Stamp TCB: The plasma sugar, free fatty acid, Cortisol and growth hormone response to insulin I. In control subjects. J Clin Invest 45:429, 1966Google Scholar
  6. 6.
    Lufkin EG, Kao PC, O’Fallon WM, et al: Combined testing of anterior pituitary gland with insulin, thyrotropin-releas ing hormone and luteinizing-hormone releasing hormone. Am J Med 75: 383, 1983CrossRefGoogle Scholar
  7. 7.
    Hershman J: Advancing in tandem: Clinical endocrinology and clinical chemistry. Clin. Chem. 29: 237, 1983PubMedGoogle Scholar
  8. 8.
    Kleinberg DL, Noel GL, Frantz AG: Galactorrhea: A study of 235 cases including 48 with pituitary tumors. N Engl J Med 295: 659, 1977Google Scholar
  9. 9.
    Robinson AG, Nelson PB: Prolactinoma in women: Current therapies. Ann Intern Med 99: 115, 1983PubMedGoogle Scholar
  10. 9a.
    Vermeulen A, Say E, Rubens R: Effect of prolactin on plasma DEA(s) levels. J Clin Endocrinol Metab 44: 1222, 1977PubMedCrossRefGoogle Scholar
  11. 9b.
    Rosen SW, Weintraub BW: Ectopic production of the isolated alpha subunit of the glycoprotein hormones. N Eng J Med 290: 1441, 1974CrossRefGoogle Scholar
  12. 9c.
    Ridge way EC, Klibanski A, Landenson PW, et al.: Pure alpha secreting pituitary adenomas. N Eng J Med 304: 1254, 1981CrossRefGoogle Scholar
  13. 10.
    Miller M, Moses AM, Streeten DH: Recognition of partial defects in antidiuretic hormone secretion. Ann Intern Med 73: 721, 1970PubMedGoogle Scholar
  14. 11.
    Hays RM: Antidiuretic hormone. N Engl J Med 295: 659, 1977Google Scholar
  15. 12.
    Constantion NV, Kakat HF: Drug-induced modifications of laboratory tests—Revised 1973. Am J Hosp Pharm 30: 24, 1973Google Scholar
  16. 13.
    Weiss ER, Rayyis SS, Nelson DH, et al: Evaluation of stimulation and suppression tests in the etiological diagnosis of Cushing’s syndrome. Ann Intern Med 71: 941, 1969PubMedGoogle Scholar
  17. 14.
    Carroll BJ, Schroeder K, Mukhopadhyay S: Plasma dexamethasone concentrations and Cortisol suppression response in patients with endogenous depression. Clin Endocrinol Metab 51: 433, 1980CrossRefGoogle Scholar
  18. 15.
    Ashcraft MW, VanHerle AJ, Vener SL, et al: Serum Cortisol levels in Cushing’s syndrome after low- and high-dose dexamethasone supression. Ann Intern Med 97: 21, 1982PubMedGoogle Scholar
  19. 15a.
    Chrousos, GP, Schultz HM, Oldfield EH, et al: The cor- ticotropin-releasing factor stimulation test: An aid in the evaluation of patients with Cushing’s syndrome. N Engl J Med 310: 622, 1984PubMedCrossRefGoogle Scholar
  20. 15b.
    Muller OA, Stalla GK, Werder K: Corticotropin releasing factor: A new tool for the differential diagnosis of Cushing’s syndrome. J Clin Endocrinol Metab 57: 227, 1983PubMedCrossRefGoogle Scholar
  21. 16.
    Winter JSD, Faiman C: Pituitary gonadal relations in male children and adolescents. PediatrRes 6: 126, 1972PubMedCrossRefGoogle Scholar
  22. 17.
    Winter JSD, Faiman C: Pituitary gonadal relationships in female children and adolescents. PediatrRes 7: 948, 1973PubMedGoogle Scholar
  23. 18.
    Kulin HE, Grumbach MM, Kaplan SL: Gonadal-hypothalamic interaction in prepubertal and pubertal man: Effect of clomiphene citrate on urinary follicle-stimulating hormone and luteinizing hormone and plasma testosterone. Pediatr Res 6: 162, 1972PubMedCrossRefGoogle Scholar
  24. 19.
    Wartofsky L, Burman KD: Alterations in thyroid function in patients with systemic illness: The “euthyroid sick” syndrome. Endocrinol Rev 3: 164, 1982CrossRefGoogle Scholar
  25. 20.
    A draft classification of diabetes mellitus and other categories of glucose tolerance.Diabetes 28: 1039, 1977Google Scholar
  26. 21.
    Merrimee TJ, Tyson JE: Hypoglycemia in man. Pathologic and physiologic variants. Diabetes 26: 161, 1977CrossRefGoogle Scholar
  27. 22.
    Hofeldt FD, Dippe S, Forsham PH: Diagnosis and classification of reactive hypoglycemia based on hormonal changes in response to oral and intravenous glucose. Am J Clin Nutr 25: 1193, 1972PubMedGoogle Scholar
  28. 23.
    Klee G: Strategies for communicating the values and limitations for endocrine tests. Clin Lab Med 2 (4): 803, 1982PubMedGoogle Scholar
  29. 24.
    Eisenbarth GS, Jackson RA: Application of monoclonal antibody techniques to endocrinology. Endocr Rev 3: 26, 1982PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Robert N. Alsever
    • 1
    • 2
  1. 1.Division of EndocrinologySouthern Colorado ClinicPuebloUSA
  2. 2.Department of MedicineUniversity of Colorado Health Sciences CenterDenverUSA

Personalised recommendations