Skip to main content

Placental Endocrinology

  • Chapter
Gynecologic Endocrinology

Abstract

The placenta is a temporary fetomaternal organ that sustains the growth and nutrition of the developing conceptus. Human beings have a villous hemo chorial placenta in which trophoblast is in direct contact with maternal blood (Fig. 3-1). Syncytiotrophoblast is the outer layer of trophoblast, which is in direct contact with this blood; it derives from the cytotrophoblast, which is most prominent in early pregnancy (Fig. 3-2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chard T, Klopper A: Placental Function Tests. New York, Springer-Verlag, 1982

    Google Scholar 

  2. Grudzindkas JG, Gordon YB, Wadsworth J, et al: Is placental function testing worthwhile? An update on placental lactogen. AustNZ J Obstet Gynaecol 21: 103–1055, 1981

    Google Scholar 

  3. Hubert C, Descombey D, Mondon F, et al: Plasma human chorionic somatomammotropin deficiency in a normal pregnancy is the consequence of low concentration of messenger RNA coding for human chorionic somatomammotropin. Am J Obstet Gynecol 147: 676–678, 1983

    PubMed  CAS  Google Scholar 

  4. Taylor NF, Shackleton CHL: Gas chromatographic steroid analysis for diagnosis of placental sulfatase deficiency: A study of nine patients. J Clin Endocrinol Metab 49: 78–86, 1979

    PubMed  CAS  Google Scholar 

  5. Van Wagenen G, Newton WH: Pregnancy in the monkey after removal of the fetus. Surg Gynecol Obstet 77: 539–552, 1943

    Google Scholar 

  6. Healy DL, Hodgen GD: The endocrinology of human endometrium. Obstet Gynecol Surv 38: 509–530, 1983

    PubMed  CAS  Google Scholar 

  7. Siler-Khodr TM, Khodr, GS: Extrahypothalamic luteinizing hormone-releasing factor (LRF): Release of immu- noreactive LRF in vitro. Fertil Steril 32: 294–296, 1979

    PubMed  CAS  Google Scholar 

  8. Corner GW, Allen WM: Physiology of the corpus luteum. II. Production of a special uterine reaction (progestational proliferation) by extracts of the corpus luteum. Am J Physiol 88: 326–339, 1929

    CAS  Google Scholar 

  9. Venning EM, Browne JSL: Urinary excretion of sodium pregnanediol glucuronidate in the menstrual cycle (an excretion product of progesterone). Am J Physiol 119: 417, 1937

    Google Scholar 

  10. Bloch K: The biological conversion of cholesterol to pregnanediol. J Biol Chem 157: 661–666, 1945

    CAS  Google Scholar 

  11. Healy DL, Chrousos GP, Schulte HM, et al: Pituitary and adrenal responses to the anti-progesterone and anti- glucocorticoid steroid RU 486 in primates. J Clin Endocrinol Metab 57: 863–865, 1983

    PubMed  CAS  Google Scholar 

  12. Sybulski S, Venning EH: The possibility of corticosteroid production by human and rat placental tissue under in vitro conditions. Can J Biochem Physiol 39: 203–214, 1961

    PubMed  CAS  Google Scholar 

  13. Bengtsson LPH, Ejarque PM: Production rate of progesterone in the last month of human pregnancy. Acta Obstet Gynecol Scand 43: 49–57, 1964

    PubMed  CAS  Google Scholar 

  14. Pearlman WH: [16-3H] Progesterone metabolism in advanced pregnancy and in oophorectomized-hysterec- tomized women. Biochem J 67:1–5, 1957

    Google Scholar 

  15. Yen SSC, Tsai CC, Naftolin F, et al: Pulsatile patterns of gonadotropin release in subjects with and without ovarian function. J Clin Endocrinol Metab 34: 671–675, 1972

    PubMed  CAS  Google Scholar 

  16. Tureck RW, Strauss JF: Progesterone synthesis by lu teinised human granulosa cells in culture: The role of de Novo sterol synthesis and lipoprotein-carried sterol. J Clin Endocrinol Metab 54: 367–369, 1982

    PubMed  CAS  Google Scholar 

  17. Healy DL, Schenken RS, Lynch A, et al: Pulsatile progesterone secretion: Its relevance to clinical evaluation of corpus luteum function. Fertil Steril 41: 114–119, 1984

    PubMed  CAS  Google Scholar 

  18. Macome JC, Bischoff, K, Uma Bai R, et al: Factors influencing placental steroidogenesis in vitroSteroids 20: 469–485, 1972

    PubMed  CAS  Google Scholar 

  19. Runnebaum B, Holzmann K, Bierwirith Y, et al: Effect of HCG on plasma progesterone during the lueal phase of the menstrual cycle and during pregnancy. Acta Endocrinol 69: 739–746, 1972

    PubMed  CAS  Google Scholar 

  20. Wilson EA, Jawad MJ: Luteinising hormone-releasing hormone suppression of human placental progesterone production. Fertil Steril 33: 91–93, 1980

    PubMed  CAS  Google Scholar 

  21. Tulchinsky D, Okada DM: Hormones in human pregnancy. IV. Plasma progesterone. Am J Obstet Gynecol 121: 293–299, 1975

    PubMed  CAS  Google Scholar 

  22. Gibb W, Lavoie JC, Roux J: In vitro conversion of pregnenolone to progesterone by term human fetal membranes. Am J Obstet Gynecol 136: 631–634, 1980

    PubMed  CAS  Google Scholar 

  23. Mitchell B, Cruikshank B, McLean D, et al: Local modulation of progesterone production in human fetal membranes. J Clin Endocrinol Metab 55: 1237–1239, 1982

    PubMed  CAS  Google Scholar 

  24. Siiteri PK, Seron-Ferre M: Fetoplacental unit and parturition in primates, in Novy MJ, Resko JA (eds): Fetal Endocrinology. New York, Academic, 1982, pp 1–34

    Google Scholar 

  25. Challis J, Patrick J, Richardson B, et al: Loss of diurnal rhythm in plasma estrone, estradiol and estriol in women treated with synthetic glucocorticoids at 34 to 35 weeks gestation. Am J Obstet Gynecol 139: 338–343, 1981

    PubMed  CAS  Google Scholar 

  26. Fräser RC, Delisle FE, Siiteri PK: Progesterone synthesis by superfused human placental minces and inhibition by Cortisol. Society for Gynecological Investigation, 27th Annual Meeting, March 19–22, Denver, Colorado, 1980, Abst. 28

    Google Scholar 

  27. Yoshimi T, Strott CA, Marshall JR, et al: Corpus luteum function in early pregnancy. J Clin Endocrinol 29: 225–231, 1969

    CAS  Google Scholar 

  28. Wiest WG: Estimation progesterone in biological tissues and fluids from pregnant women by double isotope derivative assay. Steroids 10: 279–290, 1967

    PubMed  CAS  Google Scholar 

  29. Coyle MG, Greig M, Walker J: Blood-progesterone and urinary pregnanediol and oestrogens in fetal death from severe pre-eclampsia. Lancet 2: 275–277, 1962

    PubMed  CAS  Google Scholar 

  30. Tullner WW, Hodgen GD: Effects of fetectomy on plasma estrogens and progesterone in monkeys (Macaca mulatta). Steroids 24: 887–897, 1974

    PubMed  CAS  Google Scholar 

  31. Diczfalusy E: Endocrine functions of the human feto-pla- cental units. Fed Proc 23: 791–804, 1964

    PubMed  CAS  Google Scholar 

  32. Solomon S, Fuchs F: Progesterone and related neutral steroids, in Fuchs F, Klopper A (eds): Endocrinology of Pregnancy. New York, Harper & Row, 1971, pp 66–91

    Google Scholar 

  33. Huhtaniemi I: Studies on steroidogenesis and its regulation in human fetal adrenal and testis. J Steroid Biochem 8: 491–497, 1977

    PubMed  CAS  Google Scholar 

  34. Acevedo HF, Axelrod IR, Shikawa E, et al: Studies in fetal metabolism. II. Metabolism of progesterone-414C and pregnenolone-73H in human fetal testes. J Clin Endocrinol Metab 23: 885–892, 1963

    PubMed  CAS  Google Scholar 

  35. Bloch E: Metabolism of 4-,14C progesterone by human fetal testes and ovaries. Endocrinology 74: 833–845, 1964

    PubMed  CAS  Google Scholar 

  36. Jaffe R, Pion R, Eriksson G, et al: Studies on the aro- matisation of neutral steroids in pregnant women. IV. Lack of oestrogen formation from progesterone. Acta Endocrinol 48: 413–422, 1965

    PubMed  CAS  Google Scholar 

  37. Grody WW, Schrader WT, O’Malley BW: Activation, transformation, and subunit structure of steroid hormone receptors. Endocr Rev 3: 141–163, 1982

    PubMed  CAS  Google Scholar 

  38. Raynaud JP: A tag for the progestin receptor, in McGuire WG, Raynaud JP, Baulieu EE (eds): Progesterone Receptors in Normal and Neoplastic Tissue. New York: Raven, 1977, pp 9–43

    Google Scholar 

  39. Walters MR, Clark JH: Relationship between the quantity of progesterone receptor and the antagonism of estrogen- induced uterotropic response. Endocrinology 105: 382–386, 1979

    PubMed  CAS  Google Scholar 

  40. Tseng L, Gurpide E: Effects of progestins on estradiol receptor levels in human endometrium. J Clin Endocrinol Metab 41: 402–404, 1975

    PubMed  CAS  Google Scholar 

  41. Logeat F, Vu Hai MT, Sartor P, et al: Uterine progesterone receptors during pregnancy, in Kimball KA (ed): The Endometrium. New York, SP Medical and Scientific Books, 1980, pp 127–145

    Google Scholar 

  42. Kreitmann-Gimbal B, Bayard F, Hodgen GD: Changing ratios of nuclear estrone to estradiol binding in endometrium at implantation: Regulation by chorionic gonadotropin and progesterone during rescue of the primate corpus luteum. J Clin Endocrinol Metab 52: 133–137, 1981

    PubMed  CAS  Google Scholar 

  43. Joshi SG: Progestin-regulated proteins of the human endometrium. Semin Reprod Endocrinol 1: 211–236, 1983

    Google Scholar 

  44. Thorburn GD, Challis JRG: Endocrine control of parturition. Physiol Rev 59: 863 — 918, 1979

    PubMed  CAS  Google Scholar 

  45. Csapo AL: The “seesaw” theory of parturition. CIBA Found Symp 47: 159–170, 1977

    PubMed  CAS  Google Scholar 

  46. Csapo AL, Knobil E, Van Der Molen HJ, et al: Peripheral plasma progesterone levels during human pregnancy and labor. Am J Obstet Gynecol 110: 630–632, 1971

    PubMed  CAS  Google Scholar 

  47. Turnbull AC, Patten PT, Flint APF, et al: Significant fall in progesterone and rise in oestradiol levels in human peripheral plasma before the onset of labor. Lancet 1: 101–104, 1974

    PubMed  CAS  Google Scholar 

  48. Tansey TR, Padykula HA: Cellular responses to experimental inhibition of collagen degradation in the post partum rat uterus. Anat Rec 191: 287–309, 1979

    Google Scholar 

  49. Clemens LE, Siiteri PK, Stites DP: Mechanisms of immunosuppression of progesterone on maternal lymphocyte activation during pregnancy. J Immunol 122: 1978–1985, 1979

    PubMed  CAS  Google Scholar 

  50. Shearman RP, Garrett WJ: Double-blind study of effect of 17-hydroxy progesterone caproate on abortion rate. Br Med J 1: 292–295, 1963

    PubMed  CAS  Google Scholar 

  51. Klopper A, MacNaughton MD: Hormones in recurrent abortion. J Obstet Gynaecol Br Commonw 72: 1022–1028, 1965

    Google Scholar 

  52. Trounson AO, Leeton JF, Wood C, et al: Pregnancies in the human by fertilisation in vitro and embryo transfer in the controlled ovulatory cycle. Science 212: 681–682, 1981

    PubMed  CAS  Google Scholar 

  53. Johnson JWG, Austin KL, Jones GS, et al: Efficacy of 17α-hydroxyprogesterone caproate in the prevention of premature labor. N Engl J Med 293: 675–680, 1975

    PubMed  CAS  Google Scholar 

  54. Heinonen OP, Slone D, Shapiro S: Progestagens and pregnancy, in O.P. Heinonen, et al. (eds): Birth Defects and Drugs in Pregnancy. Littleton, MA, Publishing Sciences Group, 1977, pp 126–158

    Google Scholar 

  55. MacCorquodale DW, Thayer SA, Doisy EA: The isolation of the principal estrogenic substance of liquor folliculi. J Biol Chem 115: 435–448, 1936

    CAS  Google Scholar 

  56. Marrian GF: The chemistry of oestrin. IV. The chemical nature of crystalline preparations. Biochem J 24: 1021–1030, 1930

    PubMed  CAS  Google Scholar 

  57. Kober S: Eine kolormetrische Bestimmung des Brunshor- mons (Menformon). BiochemZulschr 239: 209–212, 1931

    CAS  Google Scholar 

  58. Brown JB: A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. Biochem J 60: 185–193, 1955

    PubMed  CAS  Google Scholar 

  59. Brown JB: Urinary excretion of oestrogens during the menstrual cycle. Lancet 1: 320–323, 1955

    Google Scholar 

  60. Baird DT, Horton R, Longcope C: Steroid dynamics under steady state conditions. Recent Prog Horm Res 25: 611–648, 1969

    PubMed  CAS  Google Scholar 

  61. Zondek B, Goldberg S: Placental function and foetal death. (1) Urinary gonadotrophin tetration test in early pregnancy. (2) Urinary estradiol excretion test in advanced pregnancy. J Obstet Gynaecol Br Commonw 64: 1–9, 1957

    CAS  Google Scholar 

  62. Frandsen VA, Stakemann G: The site of production of oestrogenic hormones in human pregnancy. Acta Endo crinol 38: 383–391, 1961

    CAS  Google Scholar 

  63. EasterlingWE, SimmerH, DignamWJ, etal: Neutral C19- steroids and steroid sulfates in human pregnancy. Steroids 8: 157–178, 1966

    PubMed  CAS  Google Scholar 

  64. Ryan KJ: Hormones of the placenta Am J Obstet Gynecol 84: 1695–1713, 1962

    PubMed  CAS  Google Scholar 

  65. Crystle CD, Dubin NH, Grannis GF, et al: Investigation of estrogen precursor availability in the regulation of estrogen synthesis in normal human pregnancy. Obstet Gynecol 42: 718–724, 1973

    PubMed  CAS  Google Scholar 

  66. Siiteri PK, MacDonald PC: Placental estrogen biosynthesis during human pregnancy. J Clin Endocrinol Metab 26: 751–761, 1966

    PubMed  CAS  Google Scholar 

  67. Tilders FJH, Parker C, Barnea A, et al: The major immu- noreactive a-Melanocyte-stimulating hormone (a-MSH)- like substance found in human fetal pituitary tissue is not MSH but may be Desacetyl a-MSH (Adrenocorticotropin 1-13 NH2). J Clin Endocrinol Metab 52: 319–324, 1981

    PubMed  CAS  Google Scholar 

  68. Rudman D, Hollins BM, Lewis NC: Effects of melanotropic peptides on fetal adrenal gland. J Clin Invest 65: 822–828, 1980

    PubMed  CAS  Google Scholar 

  69. Jaffe RB, Seron-Ferre M, Crickard K, et al: Regulation and function of the primate fetal adrenal gland and gonad. Recent Prog Horm Res 37: 41–103, 1981

    PubMed  CAS  Google Scholar 

  70. Branchaud CT, Goodyer CG, Hall C, et al: Steroidogenic activity of hACTH and related peptides on the human neocortex and fetal adrenal cortex in organ culture. Steroids 31: 557–572, 1978

    PubMed  CAS  Google Scholar 

  71. Brown JB, Beischer NA, Smith MA: Excretion of urinary oestrogens in pregnant patients with cortisone and its analogues. J Obstet Gynaecol Br Commonw 75: 819–828, 1968

    PubMed  CAS  Google Scholar 

  72. Fujada K, Faiman C, Reyes FI, et al: The control of steroidogenesis by human fetal adrenal cells in tissue culture. I. Response to adrenocorticotropin. J Clin Endocrinol Metab 53: 34–48, 1981

    Google Scholar 

  73. Clements JA, Reyes FI, Winter JSD, et al: Studies on human sexual development. III. Fetal pituitary and serum and amniotic fluid concentration of LH, HCG, and FSH. J Clin Endocrinol Metab 42: 9–16, 1976

    PubMed  CAS  Google Scholar 

  74. Healy DL: Human prolactin physiology. Doctoral Thesis, Monash University, 1978

    Google Scholar 

  75. Bigazzi M, Ronga R, Lancranjan I, et al: A pregnancy in an acromegalic woman during bromocriptine treatment: Effects on growth hormone and prolactin in the maternal, fetal and amniotic compartments. J Clin Endocrinol Metab 48: 9–12, 1979

    PubMed  CAS  Google Scholar 

  76. Grumbach MM, Richards GE, Conte FA, et al: Adrenal androgens, in James VHT, Serio M, Gusisti G, Martini Leds): The Endocrine Function of the Human Adrenal Cortex. New York, Academic, 1978, pp 64–97

    Google Scholar 

  77. Parker LN, Lifrak ET, Odell WD: A 60,000 molecular weight human pituitary glycopeptide stimulates adrenal androgen secretion. Endocrinology 113: 2092–2096, 1983

    PubMed  CAS  Google Scholar 

  78. Buster JE, Abraham GE: The applications of steroid hormone radioimmunoassay to clinical obstetrics. Obstet Gynecol 46: 489–499, 1975

    PubMed  CAS  Google Scholar 

  79. Shutt DA, Smith ID, Shearman RP: Oestrone, oestradiol-17 and oestriol levels in human foetal plasma during gestation and at term. J Endocrinol 60: 30–33, 1974

    Google Scholar 

  80. Klopper A, Wilson G, Cooke I: Studies on the variability of urinary oestriol and pregnanediol output during pregnancy. J Endocrinol 43: 295–300, 1969

    PubMed  CAS  Google Scholar 

  81. Laatikainen T, Pelkonen J, Apter D, et al: Fetal and maternal serum levels of steroid sulphates, unconjugated steroids, and prolactin at term pregnancy and in early spontaneous labor. J Clin Endocrinol Metab 50: 489–494, 1980

    PubMed  CAS  Google Scholar 

  82. Tulchinsky D, Osathanondh R, Belisle S, et al: Plasma estrone, estradiol, estriol and their precursors in pregnancies with anencephalic fetuses. J Clin Endocrinol Metab 45: 1100–1103, 1977

    PubMed  CAS  Google Scholar 

  83. Belisle S, Osathanondh R, Tulchinsky D: The effect of constant infusion of unlabeled dehydroepiandrosterone sulfate on maternal plasma androgens and estrogens. J Clin Endocrinol Metab 45: 544–550, 1977

    PubMed  CAS  Google Scholar 

  84. Kauppila A, Ylikorkala O: Stable prolactin level after enhanced estradiol production following dehydroepiandrosterone sulphate. Am J Obstet Gynecol 138: 271–272, 1980

    PubMed  CAS  Google Scholar 

  85. Madden JD, Gant NF, MacDonald PC: Study of the kinetics of conversion of maternal plasma dehydroepiandrosterone sulfate to 16-hydroxy dehydroepiandrosterone sulfate estradiol, and estriol. Am J Obstet Gynecol 132: 392–395, 1978

    PubMed  CAS  Google Scholar 

  86. Korda AR, Challis JJ, Anderson ABM, et al: Assessment of placental function in normal and pathological pregnancies by estimation of plasma oestradiol levels after injection of dehydroepiandrosteorone sulphate. Br J Obstet Gynaecol 82: 656–661, 1975

    PubMed  CAS  Google Scholar 

  87. Mathur RS, Landgrebe S, Williamson HO: Progesterone, 17a-hydroxyprogesterone, estradiol, and estriol in late pregnancy and labor. Am J Obstet Gynecol 136: 25–27, 1980

    PubMed  CAS  Google Scholar 

  88. Cousins LM, Hobel CJ, Chang RJ, et al: Serum progesterone and estradiol-17 levels in premature and term labor. Am J Obstet Gynecol 127: 612–615, 1977

    PubMed  CAS  Google Scholar 

  89. Gurpide E, Schwers J, Welch MT, et al: Fetal and maternal metabolism of estradiol during pregnancy. J Clin Endocrinol Metab 26: 1355–1365, 1966

    PubMed  CAS  Google Scholar 

  90. Tulchinsky D: Placental secretion of unconjugated estrone, estradiol and estriol into the maternal and the fetal circulation. J Clin Endocrinol Metab 36: 1079–1087, 1973

    PubMed  CAS  Google Scholar 

  91. Levitz M, Katz J: Enterohepatic metabolism of estriol-3- sulphate 16-glucosiduronate in women. J Clin Endocrinol Metab 28: 862–868, 1968

    PubMed  CAS  Google Scholar 

  92. Adlercruetz H: Hepatic metabolism of estrogens in health and disease. N Engl J Med 290: 1081–1083, 1974

    Google Scholar 

  93. Puca GA, Medici N, Molinari AM, et al: Estrogen receptor of calf uterus: An easy and fast purification procedure. J Steroid Biochem 12: 105–113, 1980

    PubMed  CAS  Google Scholar 

  94. Bayard F, Damilano S, Röbel P, et al: Cytoplasmic and nuclear estradiol and progesterone receptors in human endometrium. J Clin Endocrinol Metab 46: 635–648, 1978

    PubMed  CAS  Google Scholar 

  95. Hsueh AJW, Peck EJ, Clark JH: Progesterone antagonismof the oestrogen receptor and estrogen-induced uterine growth. Nature (Lond) 254: 337–339, 1975

    Google Scholar 

  96. Giannopoulos G, Goldberg P, Shea TB, et al: Unoccupied and occupied estrogen receptors in myometrial cytosol and nuclei from non-pregnant and pregnant women. J Clin Endocrinol Metab 51: 702–705, 1980

    PubMed  CAS  Google Scholar 

  97. Clark JH, Paszko Z, Peck EJ: Nuclear binding and retention of the receptor-estrogen complex: Relation to the agonistic and antagonistic properties of estriol. Endocrinology 100: 91–96, 1977

    PubMed  CAS  Google Scholar 

  98. Martucci C, Fishman J: Direction of estradiol metabolism as a control of its hormonal action—luteotrophic activity of estradiol metabolites. Endocrinology 101: 1709–1715, 1977

    PubMed  CAS  Google Scholar 

  99. Lantta M, Karkkainen J, Lehtovirta P: Progesterone and estradiol receptors in the cytosol of the human uterine artery. Am J Obstet Gynecol 147: 627–633, 1983

    PubMed  CAS  Google Scholar 

  100. Resnick R, Killam AP, Battaglia FC, et al: The stimulation of uterine blood flow by various estrogens. Endocrinology 94: 1192–1196, 1974

    Google Scholar 

  101. Duenhoelter JH, Whalley PJ, MacDonald PC: An analysis of the utility of plasma immunoreactive estrogen measurements in determining delivery time of gravidas with a fetus considered at high risk. Am J Obstet Gynecol 125: 889–898, 1976

    PubMed  CAS  Google Scholar 

  102. Beischer NA: Low oestriol excretion: Incidence, significance and treatment in an obstetric population. Med J Aust 2: 379–380, 1975

    PubMed  CAS  Google Scholar 

  103. France JT, Liggins GC: Placental sulfatase deficiency. J Clin Endocrinol Metab 29: 138–141, 1969

    PubMed  CAS  Google Scholar 

  104. Oakey RE: Placental sulphatase deficiency: Antepartum differential diagnosis from foetal adrenal hyperplasia. Clin Endocrinol (Oxf) 9: 81–88, 1978

    CAS  Google Scholar 

  105. France JT, Seddon RJ, Liggins GC: A study of a pregnancy with low estrogen production due to placental sulfatase deficiency. J Clin Endocrinol Metab 36: 1–9, 1973

    PubMed  CAS  Google Scholar 

  106. Marton I, Oakey RE: 3ß-hydroxysteroid dehydrogenase- isomerase activity in placentae from pregnancies complicated by steroid sulphatase deficiency. J Steroid Biochem 13: 475–479, 1980

    Google Scholar 

  107. Reti LL, Kelsey GP, Stewart CR: Vaginal delivery in placentae sulphatase deficiency. Two case reports with some unusual features. Br J Obstet Gynaecol 89: 1054–1055, 1982

    PubMed  CAS  Google Scholar 

  108. Pupkin MJ, Nagey DA, Schömberg DW, et al: The de- hydroepiandrosterone loading test. III. A possible placental function test. Am J Obstet Gynecol 134: 281–288, 1979

    PubMed  CAS  Google Scholar 

  109. Tulchinsky D, Osathamondh R, Finn A: Dehydroe- piandrosterone loading in diagnosis of complicated pregnancy. N Engl J Med 294: 517–521, 1976

    PubMed  CAS  Google Scholar 

  110. Tulchinsky D, Frigoletto FD, Ryan KJ, Plasma estetrol as an index of fetal well-being. J Clin Endocrinol Metab 40: 560–567, 1975

    PubMed  CAS  Google Scholar 

  111. Jouppila P, Huhtaniemi I, Tapanainen J: Early pregnancy failure: Study by ultrasonic and clinical methods. Obstet Gynecol 55: 42–47, 1979

    Google Scholar 

  112. Noller KL, Fish CR: Diethylstilboestrol usage: Its interesting past, important present and questionable future. Med Clin North Am 58: 5793–5810, 1974

    Google Scholar 

  113. Herbst AL, Ulfelder H, Poskener DC: Adenocarcinoma of the vagina. N Engl J Med 284: 878–880, 1971

    PubMed  CAS  Google Scholar 

  114. Kaufman RH, Binder GL, Gray PM, et al: Upper genital tract changes associated with exposure in utero to di- ethylstilbestrol. Am J Obstet Gynecol 128: 51–59, 1977

    PubMed  CAS  Google Scholar 

  115. Beischer NA, Brown JB: Current status of estrogen assaysin obstetrics and gynecology. Part 2: estrogen assays in late pregnancy. Obstet Gynecol Surv 27: 303–343, 1972

    Google Scholar 

  116. MacLeod SC, Mitton DM, Avery CR: Relationship between elevated blood pressure and urinary estriols during pregnancy. Am J Obstet Gynecol 109: 375–382, 1971

    PubMed  CAS  Google Scholar 

  117. Gorwill RH, Sarda IR: Hormonal studies in pregnancy. II. Unconjugated estriol in maternal peripheral vein, cord vein and cord artery serum at delivery in pregnancies complicated by intrauterine growth retardation. Am J Obstet Gynecol 127: 17–25, 1977

    PubMed  CAS  Google Scholar 

  118. Distler W, Gabbe SG, Freeman RK, et al: Estriol in pregnancy. V. Unconjugated and total plasma estriol in the management of pregnant diabetic patients. Am J Obstet Gynecol 130: 424–431, 1978

    PubMed  CAS  Google Scholar 

  119. Whittle MJ, Anderson D, Lowensohn RI, et al: Estriol in pregnancy. VI. Experience with unconjugated plasma estriol assays and antepartum fetal heart rate testing in diabetic pregnancies. Am J Obstet Gynecol 135: 764–772, 1979

    Google Scholar 

  120. Klopper A, Stephenson R: The excretion of pregnanediol and of oestriol in pregnancy complicated by Rh immunisation. J Obstet Gynaecol Br Commonw 73: 982–985, 1966

    Google Scholar 

  121. MacDonald DJ, Scott JM, Gemmell RS, et al: A prospective study of three biochemical fetoplacental tests: Serum human placental lactogen, pregnancy-specific-glycopro- tein, and urinary estrogens and their relationship to placental insufficiency. Am J Obstet Gynecol 147: 430–436, 1983

    PubMed  CAS  Google Scholar 

  122. Beischer NA, Drew JH, Kenny JM: The effect of rest and intravenous infusion of hypertonic dextrose on subnormal estriol excretion in pregnancy. Clin Perinatol 1: 253–261, 1974

    PubMed  CAS  Google Scholar 

  123. Chang A, AbellD, Beischer NA, et al: Trial of intravenous therapy in women with low urinary estriol excretion. Am J Obstet Gynecol 127: 793–797, 1977

    PubMed  CAS  Google Scholar 

  124. Warrell DW, Taylor R: Outcome for the foetus of mothers receiving prednisolone during pregnancy. Lancet 1: 117–118, 1968

    PubMed  CAS  Google Scholar 

  125. Murphy BEP, Clark SJ, Donald IR, et al: Conversion of maternal Cortisol to cortisone during placental transfer to the human fetus. Am J Obstet Gynecol 118: 538–541, 1974

    PubMed  CAS  Google Scholar 

  126. Novy MJ, Walsh SW: Dexamethasone and estradiol treatment in pregnant rhesus macaques: Effects on gestational length, maternal plasma hormones, and fetal growth. Am J Obstet Gynecol 145: 920–931, 1983

    PubMed  CAS  Google Scholar 

  127. Funkhouser JD, Peevy KJ, Mockridge PB, et al: Distribution of dexamethasone between mother and fetus after maternal administration. Pediatr Res 12: 1053–1056, 1978

    PubMed  CAS  Google Scholar 

  128. Evans MI, Chorousos GP, Mann DL, et al: Abnormal genital masculinization in congenital adrenal hyperplasia (CAH): Attempted prevention by adrenocortical suppression in utero. Society for Gynaecological Investigation, Washington, DC, 1983, 497

    Google Scholar 

  129. Simmer HH, Frankland MV, Greipel M: Unbound unconjugated Cortisol in umbilical cord and corresponding maternal plasma. Materno-fetal gradient: Comparison of methods. Gynecol Invest 5: 199–221, 1974

    PubMed  CAS  Google Scholar 

  130. Murphy BEP: Chorionic membrane as an extra-adrenal source of foetal Cortisol in human amniotic fluid. Nature (Lond) 266: 179–180, 1977

    CAS  Google Scholar 

  131. Josimovich JB, MacLaren J: Presence in the human placenta and term serum of a highly lactogenic substance immunologically related to pituitary growth hormone. Endocrinology 71: 209–220, 1962

    PubMed  CAS  Google Scholar 

  132. Josimovich JB: Hormonal physiology of pregnancy, in Gold JJ, Josimovich JB (eds): Gynecologic Endocrinology, 3rd ed. Hagerstown, MD, Harper & Row, 1980, pp 147–174

    Google Scholar 

  133. Li CH: On the characterization of human chorionic somatomammotrophin. Ann Sclavo 12: 651–666, 1970

    CAS  Google Scholar 

  134. Li CH, Grumbach MM, Kaplan SL, et al: Human chorionic somatomammotropin (HCS): Proposed terminology for designation of a placental hormone. Experientia 24: 1188–1196, 1968

    Google Scholar 

  135. Li CH, Dixon JS, Chung D: Primary structure of human chorionic somatomammotropin (HCS) molecule. Science 173: 56–58, 1971

    PubMed  CAS  Google Scholar 

  136. Shome B, Parlow AF: Human pituitary prolactin (hPRL). The entire linear amino acid sequence. J Clin Endocrinol Metab 45: 1112–1115, 1977

    PubMed  CAS  Google Scholar 

  137. Shine J, Seeburg PH, Martial JA, et al: Construction and analysis of recombinant DNA for HCS. Nature (Lond) 270: 494–499, 1977

    CAS  Google Scholar 

  138. Owerbach D, Rutter WJ, Cooke NE, et al: The prolactin gene is located on chromosome 6 in humans. Science 212: 815–816, 1981

    PubMed  CAS  Google Scholar 

  139. Niall HD, Hogan ML, Sawer R, et al: Sequence of pituitary and placental lactogenic and growth hormones: Evolution from a primordial peptide by gene reduplication. Proc Natl Acad Sei USA 68: 866–873, 1971

    CAS  Google Scholar 

  140. Grumbach MM, Kaplan SL: Placental origin and purification of chorionic growth hormone-prolactin and its immunoassay in pregnancy. Trans NY Acad Sci 27: 167–188, 1964

    CAS  Google Scholar 

  141. Sciarra JJ, Kpalen SL, Grumbach MM: Localization of anti-human growth hormone serum within the human placenta: Evidence for a human chorionic “growth hormone— prolactin.” Nature (Lond) 199: 1005–1007, 1963

    CAS  Google Scholar 

  142. Beck P, Parker ML, Daughaday WH: Radioimmunologic measurement of human placental lactogen in plasma by a double antibody method during normal and diabetic pregnancies. J Clin Endocrinol Metab 25: 1457–1467, 1965

    PubMed  CAS  Google Scholar 

  143. Chard T: Human placental lactogen, in Martini L, James VHT (eds): Endocrinology, vol 4. London, Academic, 1983, pp 167–192

    Google Scholar 

  144. Spellacy WN, Tech ES, Buhi WC, et al: Value of human chorionic somatomammotropin in managing high-risk pregnancies. Am J Obstet Gynecol 109: 588–592, 1971

    PubMed  CAS  Google Scholar 

  145. Hochberg Z, Perlman R, Brandes JM, et al: Insulin regulates placental lactogen and estradiol secretion by cultured human term trophoblast. J Clin Endocrinol Metab 57: 1311–1313, 1983

    PubMed  CAS  Google Scholar 

  146. Macaron C, Famuyiwa O, Singh SP: In vitro effect of Dopamine and Pimozide on human chorionic somatomammotropin (HCS) secretion. J Clin Endocrinol Metab 47: 168–170, 1978

    PubMed  CAS  Google Scholar 

  147. Tyson JE, Austin KH, Favenholt JW: Prolonged nutritional deprivation in pregnancy: Change in human chorionic somatomammotropin and growth hormone secretion. Am J Obstet Gynecol 109: 1080–1086, 1971

    PubMed  CAS  Google Scholar 

  148. Josimovich JB: The human placental lactogen, in Astwood EB, Cassidy CE (eds): Clinical Endocrinology. New York, Grune & Stratton, 1968, p. 658

    Google Scholar 

  149. Novy MJ, Aubert ML, Kaplan SL, et al: Regulation of placental growth and chorionic somatomammotropin in the rhesus monkey. Am J Obstet Gynecol 140: 552–562, 1981

    PubMed  CAS  Google Scholar 

  150. Niven PAR, Ward RTH, Chard T: Human placental lactogen levels in amniotic fluid in rhesus isoimmunisation. J Obstet Gynaecol Br Commonw 81: 988–990, 1974

    PubMed  CAS  Google Scholar 

  151. Chez RA, Josimovich JB, Schultz S: The transfer of human placental lactogen across isolated amnion-chorion. Gynecol Invest 1: 312–318, 1970

    CAS  Google Scholar 

  152. Beck P, Daughaday WH: Human placental lactogen: Studies of its acute metabolic effects and disposition in normal man. J Clin Invest 46: 103–110, 1967

    PubMed  CAS  Google Scholar 

  153. Pavlou C, Chard T, Letchworth AT: Circulating levels of human chorionic somatomammotrophin in late pregnancy: Disappearance from the circulation after delivery, during labour, and circadian variation. J Obstet Gynaecol Br Commonw 79: 629–637, 1972

    PubMed  CAS  Google Scholar 

  154. Singer W, Desjardins P, Friesen HG: Human placental lactogen. An index of placental function. Obstet Gynaecol 36: 222–227, 1970

    CAS  Google Scholar 

  155. Herington AC, Graham J, Healy DL: The presence of lactogen receptors in human chorion laeve. J Clin Endocrinol Metab 51: 1466–1468, 1980

    PubMed  CAS  Google Scholar 

  156. Sideri M,, de Virgilis G, Guidobono F et al: Immunologically undetectable human placental lactogen in a normal pregnancy. Case report. Br J Obstet Gynaecol 90: 771–773, 1983

    PubMed  CAS  Google Scholar 

  157. Borody JB, Carlton MA: Isolated defect in human placental lactogen synthesis in a normal pregnancy. Case report. Br J Obstet Gynaecol 88: 447–449, 1981

    PubMed  CAS  Google Scholar 

  158. Nielsen PV, Pedersen H, Kampmann EM: Absence of human placental lactogen in an otherwise uneventful pregnancy. Am J Obstet Gynecol 135: 322–326, 1979

    PubMed  CAS  Google Scholar 

  159. Gordon YB, Chard T: The specific proteins of the human placenta: Some new hypotheses, in Klopper A, Chard T (eds): Placental Proteins. Berlin, Springer-Verlag, 1979, pp 1–21

    Google Scholar 

  160. Grumbach MM, Kaplan SL, Sciarra JJ, et al: Chorionic growth hormone prolactin: Secretion, disposition, biologic activity in man and postulated function in the “growth hormone” of the second half of pregnancy. Ann NY Acad Sci 148: 501–531, 1968

    PubMed  CAS  Google Scholar 

  161. Brinsmead MW, Bancroft BJ, Thorburn GD, et al: Fetal and maternal ovine placental lactogen during hyper- glycaemia, hypoglycaemia and fasting. J Endocrinol 90: 337–343, 1981

    PubMed  CAS  Google Scholar 

  162. Pavlou C, Chard T, London J, et al: Circulating levels of HPL in late pregnancy effect of glucose loading, smoking and exercise. Eur J Obstet Gynecol ReprodBiol 3: 45–50, 1973

    CAS  Google Scholar 

  163. Josimovich JB, Stock RJ, Tobon H: Effects of primate placental lactogen upon lactation, in Josimovich JB, Reynolds M, Cobo E (eds): Lactogenic Hormones, Fetal Nutrition and Lactation. New York, Wiley, 1974, pp 335–350

    Google Scholar 

  164. Beck P: Lactogenic activity of human chorionic somatomammotropin in rhesus monkeys. Proc Soc Exp Biol Med 140: 183–187, 1972

    PubMed  CAS  Google Scholar 

  165. Healy DL, Burger HG: Review: Human prolactin. Recent advances in physiology and therapy. Aust NZ J Obstet Gynaecol 17: 61–78, 1977

    CAS  Google Scholar 

  166. Teoh ES, Spellacy WN, Buhi WC: Human chorionic somatomammotrophin (HCS): A new index of placental function. J Obstet Gvnaecol Br Commonw 78: 673–685, 1971

    CAS  Google Scholar 

  167. Spellacy WN, Gohen WD, Carlson HL: Human placental lactogen levels as a measure of placental function. Am J Obstet Gynecol 97: 560–570, 1967

    PubMed  CAS  Google Scholar 

  168. Spellacy WN, Buhi WC, Birk SA: The effectiveness of human placental lactogen as an adjunct in decreasing perinatal deaths. Am J Obstet Gynecol 121: 835–840, 1975

    PubMed  CAS  Google Scholar 

  169. Birken S, Fetherstron J, Desmond J, et al: Partial amino acid sequence of the preprotein form of the sub-unit of HCG and identification of the site of subsequent proteolytic cleavage. Biochem Biophys Res Commun 85: 1247–1253, 1978

    PubMed  CAS  Google Scholar 

  170. Kessler MJ, Reddy NS, Shah RH, et al: Structure of N- glycosidic carbohydrate units of HCG. J Biol Chem 254: 7901–7909, 1979

    PubMed  CAS  Google Scholar 

  171. Jones GES, Grey CO, Gey MK: Hormone production by placental cells maintained in continuous culture. Bull John Hopkins Hosp 72: 26–38, 1943

    CAS  Google Scholar 

  172. Thiede HA, Choate JW: Chorionic gonadotropin localization in the human placenta by immunofluorescent staining. II. Demonstration of HCG in the trophoblast and amnion epithelium of immature and mature placentae. Obstet Gynecol 22: 433–443, 1963

    PubMed  CAS  Google Scholar 

  173. Birken S, Canfield RE: In S Segal (ed): Chorionic Gonadotropin. New York, Plenum, 1980, pp 65–83

    Google Scholar 

  174. Owens O’d M, Ryan KJ, Tulchinsky D: Episodic secretion of human chorionic gonadotropin in early pregnancy. J Clin Endocrinol Metab 53: 1307–1309, 1981

    Google Scholar 

  175. Khodr GS, Siler-Khodr T: Localisation of luteinizing hor- mone-releasing factor in the human placenta. Fertil Steril 29: 523–526, 1978

    PubMed  CAS  Google Scholar 

  176. Khodr GS, Siler-Khodr T: The effect of luteinizing hormone-releasing factor on human chorionic gonadotropin secretion. Fertil Steril 30: 301–304, 1978

    PubMed  CAS  Google Scholar 

  177. Siler-Khodr T, Khodr GS: Production and activity of placental releasing hormones, in Novy MJ, Resko JA (eds): Fetal Endocrinology, New York, Academic, 1981, pp 183–210

    Google Scholar 

  178. Healy DL, Hodgen GD: Does luteinizing hormone-releasing hormone really stimulate HCG secretion? (Submitted for publication, 1984 )

    Google Scholar 

  179. Wilson EA, Jawad MJ, Dickson LR: Suppression of human chorionic gonadotropin by progestational steroids. Am J Obstet Gynecol 138: 708–713, 1980

    PubMed  CAS  Google Scholar 

  180. Hussa RO, Pattillo RA, Ruckert ACF, et al: Effects of butyrate and debutyryl cyclic AMP on hCG-secreting trophoblastic and non-trophoblastic cells. J Clin Endocrinol Metab 46: 69–76, 1978

    PubMed  CAS  Google Scholar 

  181. Macaron C, Kynel M, Famuyiw O, et al: In vitro effect of dopamine and pimozide on human chorionic gonadotropin secretion. Am J Obstet Gynecol 135: 499–502, 1979

    PubMed  CAS  Google Scholar 

  182. Benveniste R, Speeg KV, Carpenter G, et al: Epidermal growth factor stimulates secretion of human chorionic gonadotropin by cultured human choriocarcinoma cells. J Clin Endocrinol Metab 46: 169–172, 1978

    PubMed  CAS  Google Scholar 

  183. Fusco FD, Rosen SW: Gonadotropin-producing carcinomas of the lung. N Engl J Med 275: 507–515, 1966

    PubMed  CAS  Google Scholar 

  184. McGregor WG, Kuhn RW, Jaffe RB: Biologically active chorionic gonadotropin: Synthesis by the human fetus. Science 22: 306–308, 1983

    Google Scholar 

  185. Jones WR: Immunological Fertility Regulation. Melbourne, Blackwell, 1982

    Google Scholar 

  186. Shutt DA, Lopata A: The secretion of hormones during the culture of human preimplantation embryos with corona cells. Fertil Steril 35: 413–416, 1981

    PubMed  CAS  Google Scholar 

  187. Landesman R, Coutinho EM, Saxena BB: Detection of human chorionic gonadotropin in blood of regularly bleeding women using copper intrauterine contraceptive devices. Fertil Steril 27: 1062–1066, 1976

    PubMed  CAS  Google Scholar 

  188. Harrison RF, O’Moore RR, McSweeney J: Maternal plasma hCG in early human pregnancy. Br J Obstet Gynaecol 87: 705–711, 1980

    PubMed  CAS  Google Scholar 

  189. Clements JA, Reyes FI, Winter JSD, et al: Studies on human sexual development. III. Fetal pituitiary and serum and amniotic fluid concentrations of LH, CG and FSH. J Clin Endocrinol Metab 42: 9–19, 1976

    PubMed  CAS  Google Scholar 

  190. Yen SSC, Llerena O, Little B, et al: Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man. J Clin Endocrinol Metab 28: 1763–1767, 1968

    PubMed  CAS  Google Scholar 

  191. Van Hall EV, Vaitukaitis JL, Ross GT: Effects of prog- nessive desialyation on the rate of disappearance of immu- noreactive (hCG) from plasma in rats. Endocrinology 89: 11–15, 1971

    PubMed  Google Scholar 

  192. Hodgen GD, Ross GT, Turner CK, et al: Pregnancy diagnosis by a haemagglutination inhibition test for urinary macaque chorionic gonadotropin (mCG). J Clin Endocrinol Metab 38: 927–928, 1974

    PubMed  CAS  Google Scholar 

  193. Bolton RA, Coulam CB, Ryan RJ: Specific binding of human chorionic gonadotropin to human corpora lutea in the menstrual cycle. Obstet Gynecol 56: 336–338, 1980

    PubMed  CAS  Google Scholar 

  194. Rajaniemi HJ, Ronnberg L, Kauppila A, et al: Luteinizing hormone receptors in human ovarian follicles and corpora lutea during menstrual cycle and pregnancy. J Clin Endocrinol Metab 52: 307–313, 1981

    PubMed  CAS  Google Scholar 

  195. Catt KJ, Harwood JP, Clayton RN, et al: Regulation of peptide hormone receptors and gonadal steroidogenesis. Recent Prog Horm Res 36: 557–622, 1980

    PubMed  CAS  Google Scholar 

  196. Huhtaniemi IT, Korenbrot CC, Jaffe RB: hCG binding and stimulation of testosterone biosynthesis in the human fetal testis. J Clin Endocrinol Metab 44: 963–967, 1977

    PubMed  CAS  Google Scholar 

  197. Kay MD, Jones WR: Effect of human chorionic gonadotropin on in vitro lymphocyte transformation. Am J Obstet Gynecol 109: 1029–1033, 1971

    Google Scholar 

  198. Morton H, Rolfe B, Caranagh A: Early pregnancy factor: Biology and clinical significance, in Grudzinskas JE, Feisner B, Seppale M (eds): Placental Proteins. Sydney, Academic, 1982, pp 391–406

    Google Scholar 

  199. Vaitukaitis JL, Braunstein GD, Ross GT: A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone. Am J Obstet Gynecol 113: 751–758, 1972

    PubMed  CAS  Google Scholar 

  200. Saxena BB, Hasan SH, Hadur R, et al: Radioreceptor as¬say of human chorionic gonadotropin: Detection of early pregnancy. Science 184: 973–975, 1974

    Google Scholar 

  201. Lundstrom V, Bremme K, Eneroth P, et al: Serum beta- human chorionic gonadotrophin levels in the early diagnosis of ectopic pregnancy. Acta Obstet Gynecol Scand 58: 231–233, 1979

    PubMed  CAS  Google Scholar 

  202. Seppala M, Tontti K, Ranta T, et al: Use of a rapid hCG beta-subunit radioimmunoassay in acute gynaecological emergencies. Lancet 1: 165–166, 1980

    PubMed  CAS  Google Scholar 

  203. Hurley DM, Brian R, Burger HG: Ovulation induction with subcutaneous pulsatile gonadotropin-releasing hormone: Singleton pregnancies in patients with previous multiple pregnancies after gonadotropin therapy. Fertil Steril 40: 575–579, 1983

    PubMed  CAS  Google Scholar 

  204. Talwar GP, Sharma NC, Dubey SK, et al: Isoimmunization against human chorionic gonadotropin with conjugate of processed f$-subunit of the hormone and tetanus toxoid. Proc Natl Acad Sci USA 73: 218–223, 1976

    PubMed  CAS  Google Scholar 

  205. Lin TM, Halbert SP: Placental localization of human pregnancy-associated plasma proteins. Science 193: 1249–1252, 1976

    PubMed  CAS  Google Scholar 

  206. Klopper A, Buchan P, Wilson G: The plasma half-life of placental hormones. Br J Obstet Gynaecol 85:738–747,

    Google Scholar 

  207. Grudzinskas JG, Gordon YB, Jeffrey D, et at: Specific sensitive determination of pregnancy-specific ß-glycopro- tein by radioimmunoassay: A new pregnancy test. Lancet 1: 333–335, 1977

    PubMed  CAS  Google Scholar 

  208. Gordon YB, Grudzinskas JG, Lewis JD, et al: Circulating levels of pregnancy specific ß-glycoprotein and human placental lactogen in the third trimester of pregnancy and their relationship to parity, birth weight and placental weight. Br J Obstet Gynaecol 84: 642–647, 1977

    PubMed  CAS  Google Scholar 

  209. Chapman MG, Jones WR: Pregnancy specific-1 glycoprotein (SP-1) in normal and abnormal pregnancy. Aust NZ J Obstet Gynaecol 18: 172–175, 1978

    CAS  Google Scholar 

  210. Lin TM, Haibert SP, Kiefer D, et al: Characterization of four human pregnancy-associated plasma proteins. Am J Obstet Gynecol 118: 223–236, 1974

    PubMed  CAS  Google Scholar 

  211. Bischof P: Purification and characterization of pregnancy associated plasma protein-A. Arch Gynecol 227:315–326,

    Google Scholar 

  212. Duberg S, Bischoff P, Schindler AM: In vitro production of PAPP-A, in Grudzinskas A, Chard T, Seppala M (eds): International Conference on Placental Proteins. London, Blackwell, 1981, p 6

    Google Scholar 

  213. Smith R, Bischof P, Hughes G, et al: Studies on pregnan- cy-associated plasma protein A in the third trimester of pregnancy. Br J Obstet Gynaecol 86: 882–887, 1979

    PubMed  CAS  Google Scholar 

  214. Toop K, Klopper A: Effect of anticoagulants on the measurement of pregnancy-associated plasma protein-A (PAPP-A). Br J Obstet Gynaecol 50: 150–155, 1983

    Google Scholar 

  215. Sinosich MJ, Smith DH, Grudzinskas JG, et al: The prediction of pregnancy failure by measurement of pregnan- cy-associated plasma protein A (PAPP-A) following in vitro fertilisation and embryo transfer. Fertil Steril 40: 539–541, 1983

    PubMed  CAS  Google Scholar 

  216. Bischof P: Pregnancy associated plasma protein-A: An inhibitor of the complement system. Placenta 2: 29–34, 1981

    PubMed  CAS  Google Scholar 

  217. Youngblood WW, Humm J, Lipton MA, et al: Thy- rotropin-releasing hormone-like bioactivity in placenta: Evidence for the existence of substances other than pyroglu-His-Pro-NH2 (TRH) capable of stimulating pituitary thyrotropin release. Endocrinology 106: 541–546, 1980.

    PubMed  CAS  Google Scholar 

  218. Nisula BD, Tahadouros GS, Carayon P: Primary and secondary biologic activities intrinsic to the human chorionic gonadotropin molecule, in Segal SJ (eds): Chorionic Gonadotropin. New York, Plenum, 1980, pp 17–35

    Google Scholar 

  219. Karim SMM: Action of prostaglandin in the pregnant woman. Ann NY Acad Sci 180: 483–498, 1971

    PubMed  CAS  Google Scholar 

  220. Armstrong JM, Lattimer N, Moncade S, et al: Comparison of the vasodepressor effects of prostacyclin and 6-oxo- prostaglandin F1 with those of prostaglandin E2 in rats and rabbits. Br J Pharmacol 62: 125–130, 1978

    PubMed  CAS  Google Scholar 

  221. Miyamori I, Fitzgerald GA, Brown MJ, et al: Prostacyclin stimulates the renin angiotensin system in man. J Clin Endocrinol Metab 49: 943–944, 1979

    PubMed  CAS  Google Scholar 

  222. Omini C, Folco GC, Pasargiklian R, et al: Prostacyclin (PGI2) in the pregnant human uterus. Prostaglandins 17: 113–120, 1979

    PubMed  CAS  Google Scholar 

  223. Bamford DS, Jogee M, Williams KI: Prostacyclin formation by the pregnant human myometrium. Br J Obstet Gynaecol 87: 215–218, 1980

    PubMed  CAS  Google Scholar 

  224. Siegl AM, Smith JB, Silver MJ, et al: Selective bindingsite for [3H]prostacyclin on platelets. J Clin Invest 63:215–220, 1979

    Google Scholar 

  225. Rakoczi I, Tihanyi K, Falkay G, et al: Prostacyclin production in trophoblast, in Lewis PJ, Moncada S, O’Grady J (eds): Prostacyclin in Pregnancy. York, Raven, 1983, pp 15–25

    Google Scholar 

  226. Remuzzi G, Misani R, Muratore D, et al: Prostacyclin and human foetal circulation. Prostaglandins 18: 341–348, 1979

    PubMed  CAS  Google Scholar 

  227. Downing I, Shepard GL, Lewis PJ: Reduced prostacyclin production in pre-eclampsia. Lancet 2: 1374, 1980

    PubMed  CAS  Google Scholar 

  228. Lewis PJ: Does prostacyclin deficiency play a role in preeclampsia?, in Lewis PJ, Moncade S, O’Grady J (eds): Prostacyclin in Pregnancy. New York, Raven, 1983, pp 215–220

    Google Scholar 

  229. Tyson JE, Hwang P, Guyda H, et al: Studies of prolactin secretion in human pregnancy. Am J Obstet Gvnecol 113: 14–20, 1972

    CAS  Google Scholar 

  230. Josimovich JB, Weiss G, Hutchinson DL: Sources and disposition of pituitary prolactin in maternal circulation, amniotic fluid, fetus and placenta in the pregnant rhesus monkey. Endocrinology 94: 1364–1371, 1974

    PubMed  CAS  Google Scholar 

  231. Maslar IA, Riddick DH: Prolactin production by human endometrium during the normal menstrual cycle. Am J Obstet Gynecol 135: 751–754, 1979

    PubMed  CAS  Google Scholar 

  232. Clements J, Whitfield P, Cooke N, et al: Expression of the prolactin gene in human decidua-chorion. Endocrinology 112: 1133–1134, 1983

    PubMed  CAS  Google Scholar 

  233. Golander A, Hurley T, Barrett J, et al: Prolactin synthesis by human chorion-decidiual tissue: A possible source of prolactin in the amniotic fluid. Science 202: 311–313, 1978

    PubMed  CAS  Google Scholar 

  234. Healy DL, Kimpton WG, Muller HK, et al: The synthesis of immunoreactive prolactin by decidua-chorion. Br J Obstet Gynaecol 86: 307–313, 1979

    PubMed  CAS  Google Scholar 

  235. Daly DC, Maslar IA, Riddick DH: Term decidua response to estradiol and progesterone. Am J Obstet Gynecol 145: 679–683, 1983

    PubMed  CAS  Google Scholar 

  236. Healy DL, Herington AC, O’Herlihy C: Chronic idiopathic polyhydramnios: Evidence for a defect in the chorion laeve receptor for lactogenic hormones. J Clin Endocrinol Metab 56: 520–523, 1983

    PubMed  CAS  Google Scholar 

  237. Williams RF, Barker DL, Cowan BD, et al: Hyperprolac- tinemia in monkeys: Induction by an estrogen-progesterone synergy. Steroids 38: 321–331, 1981

    PubMed  CAS  Google Scholar 

  238. Handwerger S, Barry S, Markett E, et al: Stimulation of the synthesis and release of decidual prolactin by a placental polypeptide. Endocrinology 112: 1370–1374, 1983

    PubMed  CAS  Google Scholar 

  239. Handwerger S, Barry S, Barrett J, et al: Inhibition of the synthesis and secretion of decidual prolactin by arach- idonic acid. Endocrinology 109: 2016–2021, 1981

    PubMed  CAS  Google Scholar 

  240. Markoff E, Howell S, Handwerger S: Inhibition of decidual prolactin release by a decidual peptide. J Clin Endocrinol Metab 57: 1282–1286, 1983

    PubMed  CAS  Google Scholar 

  241. Healy DL, Muller HK, Burger HG: Immunofluorescence shows localisation of prolactin to human amnion. Nature (Lond) 265: 642–643, 1977

    CAS  Google Scholar 

  242. Riddick DH, Maslar I A: The transport of prolactin by human fetal membranes. J Clin Endocrinol Metab 52: 220–224, 1981

    PubMed  CAS  Google Scholar 

  243. Leontic EA, Schrueter JJ, Andreassen B, et al: Further evidence for the role of prolactin on human fetoplacental osmoregulation. Am J Obstet Gynecol 133: 435–438, 1979

    PubMed  CAS  Google Scholar 

  244. Healy DL: The clinical significance of endometrial PRL. Aust NZ J Obstet Gynecol 24: 111–115, 1984

    CAS  Google Scholar 

  245. Josimovich JB, Merisko K, Boccella L, et al: Binding of prolactin by fetal rhesus cell membrane fractions. Endocrinology 100: 557–563, 1977

    PubMed  CAS  Google Scholar 

  246. Josimovich JB, Merisko K, Boccella L: Amniotic prolactin control over amniotic and fetal extracellular fluid water and electrolytes in the rhesus monkey. Endocrinology 100: 564–570, 1977

    PubMed  CAS  Google Scholar 

  247. Knazek RA, Christy RJ, Watson KC, et al: Prolactin modifies follicle-stimulating hormone-induced prostaglandin synthesis by the rat granulsa cell. Endocrinology 109: 1566–1572, 1981

    PubMed  CAS  Google Scholar 

  248. Mendelson CR, Johnston JM, MacDonald PC, et al: Multi- hormonal regulation of surfactant synthesis by human fetal lung in vitro. J Clin Endocrinol Metab 53: 307–317, 1981

    CAS  Google Scholar 

  249. Williams L, Warwick L, (eds): Gray’s Anatomy, 36th ed, Philadelphia, Saunders, 1980, p. 125 (fig. 2. 39 )

    Google Scholar 

  250. Johansson ED, and Johansson LE: Progesterone levels in amniotic fluid and plasma for women, I. Levels duringnormal pregnancy. Acta Obstet Gynecol Scand 40: 339–344, 1971

    Google Scholar 

  251. Beischer NA, Brown JB, Smith MA, Townsend L: Studies in prolonged pregnancy. II. Clinical research and urinary estriol excretion in prolonged pregnancy. Amer J Obstet Gynecol 103: 483 - 488, 1969

    CAS  Google Scholar 

  252. Healy DL, Hodgen GD: The endocrinology of human endometrium. Obstet Gynecol Survey 38: 509–530, 1983

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Publishing Corporation

About this chapter

Cite this chapter

Healy, D.L. (1987). Placental Endocrinology. In: Gold, J.J., Josimovich, J.B. (eds) Gynecologic Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2157-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2157-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9272-2

  • Online ISBN: 978-1-4613-2157-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics