Abstract
Virilization represents a natural sequence of events occurring in boys at the time of puberty. This process follows the surge of endogenous testosterone secretion1 and gradually transforms the child into an adult male. Virilization in women is an unnatural occurrence, frequently insidious in onset, usually associated with alarm and fear of societal rejection. The minor signs of virilization include coarse (terminal) body hair, acne, terminal facial hair, and menstrual disturbances (oligo- or amenorrhea). The more severe signs in the spectrum of events include clitorimegaly, shoulder muscle hypertrophy, temporal balding, deepening of the voice, and breast atrophy.2–4 Virilization in women can in most cases be attributed to an overproduction of testosterone.5,6 Figure 23–1 demonstrates a parallel increase in testosterone production rates with progressive signs of virilization. Fortunately, in most women with signs of virilization, testosterone production is only mildly elevated, and clinical symptoms remain in the “minor” categories.
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Kirschner, M.A. (1987). Hirsutism and Virilism in Women. In: Gold, J.J., Josimovich, J.B. (eds) Gynecologic Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2157-6_23
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